Myelin is critical for optimal brain function and mental health.
What is myelin?
Myelin is a fatty, white substance that wraps around the end of many nerve cells. It forms an electrically insulating sheath that increases nerve condition speeds. In other words, it allows your brain to send information faster and more efficiently, making it absolutely essential for the optimal functioning of your nervous system (39, 40).
So not surprisingly, it plays a key role in determining intelligence and improving cognitive performance (41, 42).
The production of myelin throughout the nervous system is called myelination or myelinogenesis.
But demyelination can also happen.
This happens when the myelin that insulates your nerves is destroyed or deteriorates, leading to mental health symptoms and neurodegenerative diseases (44).
Multiple sclerosis is one of the more common demyelinating condition, but a number of neurological and psychiatric illnesses have been linked to demyelination, including (45):
Attention deficit hyperactivity disorder
If you have one of these conditions and suspect you might have symptoms of demyelination, don’t worry.
There are dietary and lifestyle modifications that can help your body re-manufacture myelin. Studies show that oligodendrocyte cells are responsible for the formation of new myelin in both the injured and normal adult brains (43).
Here are 26 holistic ways to increase oligodendrocyte cells and promote the regeneration of myelin.
1. Deep Sleep and Melatonin
Research has found that sleep increases the production of oligodendrocyte precursor cells (OPCs).
One study found that production of OPCs doubled in mice while they slept. The mice that were forced to stay awake had higher levels of stress hormones and higher rates of brain cell death (1-2).
Researchers believe this means that sleep loss can aggravate symptoms of multiple sclerosis.
That’s why getting at least 7 hours of high-quality, restorative sleep is so critical.
But it’s not just the amount of sleep you get that’s important. It’s also the quality of your sleep.
The researchers found that the production of the myelin-forming cells increased the most during deep, rapid-eye movement (REM) sleep.
Melatonin, your body’s sleep hormone, has also been shown to promote myelination by significantly reducing inflammation in the brain (46).
Here are some actions you can take to naturally produce more melatonin, maximize the quality of your sleep, and make sure you get deeper sleep:
Expose your eyes to sun in the morning
Lie on this acupressure mat for 10 minutes before bed
Turn off household lights, get red light bulbs, install f.lux on your computer and/or wear blue-blocking glasses as soon as it's dark outside. These glasses block out blue light in your environment. Blue light suppresses your body’s production of melatonin. You can read more about blue light here.
Go to bed at the same time every night
Don’t eat for 3 hours before bed
Take this sleep supplement, which contains magnesium and a number of other natural compounds that I’ve used over the years to promote the production of melatonin. You can use the coupon code FIVE$45496275 for a 5% discount.
2. Iodine and Thyroid Hormones
Other studies show that thyroid hormones stimulate the expression of myelin protein genes, and promote remyelination in the brain by enhancing oligodendrocyte maturation (8, 9).
I make sure I get enough iodine by taking this multimineral.
And you can read more about how to support your thyroid and enhance the production of thyroid hormones here.
I also recommend getting a Complete Thyroid Panel done regularly.
3. Vitamin C
Vitamin C is known to participate in myelin formation (10, 11).
Vitamin C can be found in foods such as peppers, citrus fruits, green leafy vegetables, broccoli, tomatoes, and berries.
You can also take it in supplement form.
As I’ve discussed before, zinc is an essential trace mineral that activates several hundred enzymatic reactions, including neurotransmission.
It’s estimated that 2 billion people in the world are deficient in zinc, and six different studies show that subclinical deficiency of zinc impairs brain function in children and adults (14-16).
So, if you struggle with a brain or mental health disorder, it’s quite possible that you’re deficient.
Zinc also affects myelination. The mineral is needed for myelin proteins to work properly, and research shows that a deficiency in zinc leads to a reduction in myelin formation and myelin recovery (17).
Some of the best food sources of zinc include oysters, grass-fed beef, pumpkin seeds, cashews, mushrooms and spinach.
But I still recommend at least short-term supplementation to ensure you get enough.
I created and take the Optimal Zinc supplement.
Cholesterol is a waxy, fat-like substance that’s found in all cells of the body.
Your body needs cholesterol to make hormones and vitamin D.
And it’s an indispensable component of myelin.
Without it, myelin membrane growth is “severely perturbed” (18).
So just like you shouldn’t be afraid of saturated fat, you shouldn’t be afraid of eating cholesterol-rich foods.
Some of the best sources of cholesterol include grass-fed butter or ghee, beef liver and pastured egg yolks.
Lithium is predominantly known as a medication given to bipolar patients to manage their symptoms.
However, it’s also an essential mineral.
Bipolar patients are often given high doses of lithium carbonate.
Research shows that lithium stimulates the expression of myelin genes, restores the myelin structure, and promotes remyelination (19).
You can get lithium here.
7. Oxygen Therapy
Hyperbaric oxygen therapy (HBOT) is a treatment that enhances healing and recovery after injury to the central nervous system.
Patients inhale 100% oxygen in a total body chamber.
Usually, oxygen is transported throughout the body only by red blood cells. But with HBOT, oxygen is dissolved into all body fluids, including the fluids of the central nervous system.
This leads to oxygen being carried to areas of the body where circulation is diminished or blocked. As a result, extra oxygen can reach all damaged tissues, including areas that need to heal.
Researchers have found that HBOT can cause "significant remyelination" (83-84).
Other studies show that it can alleviate myelin damage (85).
You’ll need to find a practitioner or clinic in your area that provides this treatment.
HBOT can be expensive though. That's why I decided to buy my own oxygen concentrator. An oxygen concentrator is much less expensive than HBOT but it still helps a lot. My doctor recommended it to me and it has helped me recover.
I did a lot of research before buying my own and got this one. You can get it here or through Amazon. I use it almost every day. It's the best option on the market. You can also get a refurbished one for cheaper.
Check out my full article about oxygen therapy for more information.
8. Ketogenic Dieting
A ketogenic diet is a very low-carb diet – less than 50 grams of carbs per day.
When you restrict carbohydrate-rich foods – such as grains, sugar, and even potatoes, legumes and fruit – your body enters ketosis, a metabolic state in which your body and brain run on fatty acids and “ketones” instead of glucose.
So if you’re trying to rebuild myelin sheath, you should consider a cyclic ketogenic diet.
I follow a ketogenic diet every so often.
I also take Optimal Ketones.
Optimal Ketones are exogenous ketones that help my body get into a state of ketosis more quickly. They immediately increase my mental clarity.
Iron is an essential mineral that is present in all cells and plays a role in several vital functions, including oxygen consumption and ATP production.
It’s also important for myelin production.
Studies show that low iron levels lead to a reduction in myelination, and normal iron levels support the formation of myelin (20).
In most cases, I don’t recommend supplementing with iron. Instead, get it from food.
Beef liver is the best source. I take these beef liver capsules.
10. Low Level Laser Therapy
Low-level laser therapy (LLLT), or photobiomodulation, is a treatment that uses low-level (low-power) lasers or light-emitting diodes (LEDs) to stimulate brain cells, helping them function better.
Most doctors don't know about LLLT; but not every doctor.
Researchers have found that LLLT can increase the total number of myelinated axons (79-81).
LLLT has also been shown to restore normal levels of myelin in animals (81-82).
I previously wrote about my experience with low-level laser therapy here.
I use this device and apply the infrared light directly to my forehead.
I also use the Vielight 810, which is an intranasal device with 810 nm of near infrared light (If you decide to try the Vielight, you can use the coupon code JORDANFALLIS for a 10% discount).
I encourage you to check out my full article about it for more information.
Phosphatidylserine is a fat-soluble amino acid compound that plays a key role in optimal cognitive function. High amounts of phosphatidylserine can be found within the brain, and supplementation has been shown to improve attention and memory, especially in the elderly (21-23).
Researchers have also concluded that phosphatidylserine is required for healthy nerve cell membranes and myelin (24).
It’s been shown to enhance memory and reduce stress-induced fatigue.
It’s the precursor to almost all other steroid hormones, including DHEA, progesterone, testosterone, estrogens, and cortisol.
Pregnenolone and other steroid hormones regulate, repair, rebuild and increase the production of myelin (25-28).
I personally tried this pregnenolone. It did give me a boost in brain function and mental energy. However, it also made me angry and irritable so I stopped taking it. This happens to some people, but a lot of people don't experience this. It's worth trying to see how you react. You can get it here.
Uridine is a nucleotide base found in beer.
I don’t recommend drinking beer, but supplementing with pure uridine can protect the brain, enhance cognition, and increase mood and motivation.
It’s been proven to help treat “myelin sheath lesion” in several experimental and clinical studies (29, 30).
14. Herbs That Increase Myelin
“Withanoside IV” is one of the main therapeutic compounds in ashwagandha and research shows that it can increase myelin levels in the nervous system (31).
I take this ashwagandha during periods of high stress.
It’s beneficial effects of cognition may be because it significantly increases the number of myelinated axons (34).
Inositol is a small molecule structurally similar to glucose that is involved in cellular signalling.
At high doses, it reduces anxiety.
Research shows that animals treated with inositol have significantly fewer demyelinating lesions (32).
I now take a normal amount found in this B complex.
I previously wrote a full article about inositol here.
16. Lion’s Mane
Hericium Erinaceus – better known as Lion’s mane mushroom – might be my favourite way to regenerate myelin.
Research shows that lion’s mane increases the rate of myelination, and the process of myelination begins earlier in the presence of the mushroom (33).
I take this lion’s mane mushroom. It’s one of the highest-quality lion’s mane mushroom supplements that I could find from a reputable brand. I spent a lot of time researching and looking into different sources because not all lion's mane supplements are high-quality and effective, and I settled on this one. You can get it here or here.
17. Consume Flavonoids
There are several flavonoids, a diverse group of phytonutrients found in fruits and vegetables, that have been demonstrated to promote myelination.
Quercetin, one plant flavonoid in particular with potent antioxidant action, has been shown to increase the number of oligodendrocyte precursor cells and myelin basic protein cells (36).
18. Learn or Experience Something New
You can also generate new myelin by learning something new and exposing yourself to novel life experiences.
For example, one report showed that learning a new instrument leads to increased myelin in areas of the brain involved with musical performance.
The researchers explain that myelin increased proportionately to the number of hours each person had practiced the instrument (38).
So the more you practice and try to learn something, the more myelin you generate.
It clearly does so much good, so it’s not too surprising that it also supports myelin formation.
Research shows that long-term exercise improves memory by restoring myelin (47).
Running has also been shown to increase myelin and delay the progression of demyelination, and therefore delays the progression of Alzheimer’s disease (48).
Lastly, researchers have found that exercise increases mitochondrial activity, which then increases myelination (49).
Many brain health experts recommend exercise as their number one piece of advice for optimal brain health.
This is exercise routine I try to follow consistently:
Lift heavy weights 1-4 times per week
High-intensity interval sprinting 1-2 times per week
Walk as much as I can (ideally 30-60 minutes every day)
Walking, weightlifting and sprinting are the best forms of exercise, but you should choose a sport or exercise routine that you enjoy, so that you’ll stick with it consistently
Brain-derived neurotrophic factor, also known as BDNF, is a naturally-occurring hormone in the brain that improves brain function and lowers your risk of mental disease.
It also regulates the myelination process.
Research shows that BDNF produces a long-term increase in both the rate and extent of myelination, and enhances and accelerates myelin formation (50).
I previously provided 21 ways to boost BDNF in this post.
When I lived in a moldy home, suffered multiple concussions and was placed on antidepressants, my testosterone plummeted.
No conventional doctor tested my testosterone because they assumed every a man in his 20s would have healthy levels.
But they were wrong.
Eventually I saw a functional medicine doctor and he found out that I had the testosterone levels of an old man.
I was put on testosterone replacement therapy for almost one year to get my levels back to normal. And over that time, I saw a huge increase in my brain and mental health.
This may be because testosterone has been shown to stimulate the formation of new myelin and reverse myelin damage (51).
Researchers have also concluded that hormone replacement should be a considered treatment for males who have multiple sclerosis, as it can stall (and perhaps even reverse) the neurodegeneration associated with MS (52).
Omega-3 fatty acids are essential fats that your body cannot produce itself. They are found primarily in fish and are necessary for the normal electrical functioning of your brain and nervous system.
They appear in most of my posts because they are so critical for brain and mental health and affect so many aspects of wellness.
And now researchers have found that they also help your body produce myelin, (53, 54).
According to Judy Graham, author of the book Managing Multiple Sclerosis Naturally: A Self-Help Guide to Living with MS, myelin cell membranes that contain omega-3 fatty acids are more fluid, which improves the efficiency of nerve impulse conduction.
She also points out in her book that rates of multiple sclerosis are lower in areas of high fish consumption.
23. Vitamin D and Vitamin K2
Vitamin D is a fat-soluble vitamin that our skin synthesizes when exposed to the sun.
Research shows that the Vitamin D receptor boosts the regeneration of myelin (55).
Vitamin D also significantly increases myelination in rats (56).
It’s best to get your Vitamin D from sunlight, but most people can’t get enough, especially during the winter.
It's much better and more effective than taking a Vitamin D supplement.
If you do decide to supplement, it’s a good idea to take Vitamin K2 along with Vitamin D3, as it has also been shown to support myelin (57).
I also highly recommend checking your Vitamin D levels. It's one of the most important tests you can take for your health.
Choline is an essential B vitamin that most people don’t consume enough of, because very few foods in the Western diet contain it.
It’s also a component of myelin and supports myelin production.
Research shows that the choline pathway promotes remyelination, and enhances the repairing and rebuilding of myelin sheath (64).
Citicoline (also known as CDP-Choline) is the most bioavailable form of choline.
One study found that citicoline enhances myelin regeneration and increases remyelination in the central nervous system. The researchers concluded that citicoline could become a promising substance for patients with multiple sclerosis because of its regenerative action combined with its excellent safety profile (63).
That’s why I recommend supplementing with it. It’s one of my favourite supplements for optimal brain and mental health. I personally take citicoline every day now, and I find it improves my focus and mental energy. It's included in the Optimal Brain supplement. You can get it here, and Amazon also now carries it.
25. Reduce Inflammation
Reducing inflammation throughout your entire body is a key step towards protecting and regenerating myelin.
Researchers have found that inflammatory cytokines reduce myelination, and high levels of inflammation are often found in people with multiple sclerosis (65).
The best way to reduce inflammation is by following an anti-inflammatory diet.
You should strive to eliminate all gluten, refined carbohydrates (particularly flour), and processed food from your diet, and increase your intake of vegetables, fruits, wild fish, grass-fed beef and pastured chicken.
My free Grocery Shopping Guide for Optimal Brain Health contains a bunch of healthy low-inflammatory foods that you can eat on a regular basis.
I also recommend testing for C-Reactive Protein, which is a general marker of inflammation. That way you'll know if it's one of your problems.
26. B Vitamins and Methylation
A number of different B vitamins can help your body regenerate myelin.
Vitamin B12 plays a key role in the generation and function of myelin.
Researchers have found that low vitamin B12 levels are significantly associated with myelin degeneration (66, 68).
Other studies have also shown that people with multiple sclerosis often have abnormally low levels of vitamin B12, and vitamin B12 injections significantly improve their symptoms (67).
According to Dr. Perlmutter, author of Brain Maker and Grain Brain, vitamin B12 deficiency enhances the destruction of myelin and compromises the ability of the body to repair and rebuild damaged myelin sheath.
Folate is another B vitamin that plays an important role in the maintenance of myelin. Studies have shown that a deficiency can lead to reduced levels of myelin (69-70).
S-adenosylmethionine (SAMe) isn’t a B vitamin, but along with folate and B12, it is involved with methylation, and has been shown to increase the development of myelin (71).
One amazing study found that biotin (Vitamin B7) activates enzymes involved in myelin synthesis and 91% of patients with multiple sclerosis improved with high doses of biotin. Two multi-centric double-blind placebo-controlled trials are currently underway (72).
Lastly, pantothenic acid (Vitamin B5) can indirectly help with myelin formation because it helps with the synthesis of fatty acids and myelin is mostly made up of fat. Myelin has been shown to degenerate in chickens that are deficient in B5 (73).
I used to experiment and supplement with individual B vitamins but I’ve now settled on taking just one B complex as needed. I take this one. It contains the bioactive forms of all the B vitamins.
27. Reduce Exposure to Electromagnetic Fields (EMFs)
“I have no doubt in my mind that, at the present time, the greatest polluting element in the Earth’s environment is the proliferation of electromagnetic fields.” - Dr. Robert Becker, Nobel Prize nominee and author of The Body Electric: Electromagnetism And The Foundation Of Life
You won't hear many people talk about this but it needs to be acknowledged.
An increasing amount of research is showing that electromagnetic frequencies emitted from Wi-Fi, laptops, and cellphones can negatively affect the brain and produce widespread neuropsychiatric effects including depression (59).
It’s an inconvenient truth that needs to be talked about, rather than downplayed, ignored and dismissed.
Some people are more sensitive to them than others. I’m one of them.
Two environmental doctors have told me that I’m sensitive to environmental radiation, and some of my symptoms can be traced back to EMF hypersensitivity. It's likely why I benefited so much from neurofeedback, as EMFs can affect brainwaves (74-78).
I suspect a lot of people are dealing with the same problem.
This research paper explains that there is an association between EMF exposure and myelin deterioration, which may account for many of the symptoms that people with EMF hypersensitivity experience (58).
So if you’re trying to rebuild myelin, it’s a good idea to limit your exposure to EMFs.
How do you that?
I'm still learning about how to manage and combat them, but here are some initial steps you can take:
Get an EMF meter to determine your exposure. I use the Cornet ED88T. It's the best option that is currently available. It measures electric, magnetic and radiofrequency fields. It's like having three meters in one. You can get it here.
Put your phone on airplane mode when you’re not using it. Or use a radiation-blocking phone case such as Safe Sleeve. I did a lot of research into radiation-blocking cases and Safe Sleeve is the best on the market. They are manufactured with materials that have been 3rd-party tested to block 99.9% of radiation coming off a cell phone.
Turn off Wi-Fi at night while you’re sleeping.
This is just the tip of the iceberg. There are many other steps you can take, and I plan on writing more about this soon because it isn’t discussed enough.
This may seem like “woo-woo” but it’s a real issue. And I suspect it will eventually become one of the biggest issues of our time.
You don’t have to let your brain deteriorate over time.
You have the power to maintain it and rebuild the myelin within it.
Overall, the above 25 steps can help your body regenerate myelin. They have really helped me.
I hope you implement some of them into your daily life and you notice your brain functions more optimally.
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Reviewed by Dr. Richard Nahas, MD CCFP DCAPM ABIM