Insulin-like growth factor 1 (IGF-1) is a hormone in your body that’s absolutely critical for optimal physical and mental performance.
It’s produced by the liver.
And once it’s released into the bloodstream, it stimulates growth, regenerates cells, and helps your body recover and repair itself.
It’s known to play an important role in childhood growth and development, and helps you build and maintain muscle throughout your entire adult life.
But it doesn’t just affect your muscles…
It also powerfully supports your brain.
Unfortunately, your IGF-1 levels drastically decrease as you get older, contributing to cognitive decline.
Your levels can even drop when you’re young, especially if you’ve had a brain injury or developed a chronic health issue.
Luckily, there are many different ways to optimize and increase IGF-1 levels.
Researchers have found that IGF-1 levels can be manipulated to improve quality of life and delay the deteriorating effects of brain aging.
It doesn’t matter if you’re old, run down, or chronically ill...
The 25 strategies in this article can naturally boost IGF-1 production and amplify your cognitive performance.
I’ve divided this article into four main sections:
The benefits of IGF-1
Food and nutrients that increase IGF-1
Supplements and herbs that increase IGF-1
Lifestyle habits and therapies that increase IGF-1
Continue reading to learn more and discover how to increase IGF-1.
The Benefits of Increasing Insulin-Like Growth Factor (IGF-1) and How It Affects Your Brain
IGF-1 is a very important blood marker to monitor.
Yet many doctors don’t check it.
This is a shame because it plays a crucial role in healing and brain health.
Research suggests that IGF-1 levels tend to be low in people struggling with chronic illness and systemic inflammation (87-88, 103).
Studies also show that IGF-1 crosses the blood–brain barrier and affects the brain and cognitive function (113, 116, 129-131).
Alzheimer’s disease and dementia are associated with lower IGF-1 levels, and increasing IGF-1 can help prevent the accumulation of amyloid plaque in the brain (104-108).
Other neurodegenerative diseases, such as Amyotrophic Lateral Sclerosis (ALS) and Parkinson’s disease, are also associated with lower IGF-1 levels, and increasing IGF-1 can help lower your risk of developing these diseases (109-112).
Researchers have also found that IGF-1 and higher levels of IGF-1 can lead to the following cognitive and neurological health benefits:
IGF-1 improves learning and memory (94-95)
IGF-1 speeds up executive functions and mental processing (96)
IGF-1 increases brain-derived neurotrophic factor (BDNF) (97)
IGF-1 improves gut health and helps reduces gut permeability, which affects brain health (98-102)
IGF-1 promotes synaptogenesis (114)
IGF-1 stimulates myelin production (115)
IGF-1 supports neurogenesis and neuroplasticity (127-128)
But it doesn’t stop there...
Many people who have had brain injuries also end up having low levels of IGF-1.
This is because your brain signals to your liver to produce IGF-1. And when your brain gets injured, it can stop doing this efficiently (122-126).
Research clearly shows that IGF-1 levels often drop after traumatic brain injuries (TBI), which worsens cognitive dysfunction. This even happens in people who have had mild TBIs. But strategies to increase IGF-1 can increase brain cell survival, repair the brain, and improve cognition after TBIs (117-121).
I personally had low IGF-1 levels after multiple head injuries.
But I had no idea for the longest time.
I eventually found a doctor who actually listened to me, we checked my levels, and I found out they were low.
I then implemented many of the strategies below to increase and normalize my IGF-1 levels, and I felt better.
It’s important to test and monitor your IGF-1 levels like I did because you don’t want your IGF-1 levels getting too high either.
Best Foods and Nutrients to Increase Insulin-Like Growth Factor 1 (IGF-1) Naturally
Zinc is an essential mineral for brain health.
That’s a problem because a zinc deficiency decreases IGF-1 levels in humans (8).
Luckily, zinc supplementation can help.
Researchers have found that supplementing with zinc significantly increases circulating IGF-1 levels, and increases the synthesis and action of IGF-1 in the body (10-13).
I created and take the Optimal Zinc supplement to make sure my zinc and IGF-1 levels are optimal. I created it because I want to give my clients and readers the very best zinc supplement so that they can experience superior results. I have found that many zinc supplements on the market fall short. Optimal Zinc includes several other nutrients (co-factors) that increase the absorption of zinc.
Besides supplementing, you should also eat plenty of healthy, whole foods that contain zinc.
Some of the best foods to optimize your zinc levels include:
These foods are included in my Free Grocery Shopping Guide for Optimal Brain and Mental Health.
Check out my previous post all about zinc for more steps you can take to increase your zinc levels.
Eating enough high-quality protein is critical if you want to increase your IGF-1 levels.
Research shows that low protein intake is associated with a major reduction in IGF-1 (69).
Meanwhile, high-protein diets can increase IGF-1 levels (66-67, 71-72).
Animal protein and red meat in particular has been shown to increase IGF-1 concentrations (68, 70).
It's important to keep in mind that muscle meat (chicken breasts, lean beef) shouldn’t be your only source of animal protein.
Our ancestors didn’t eat this way, so neither should we.
Your body prefers and expects to receive a balance of amino acids from different parts of whole animals.
That’s why I recommend “head-to-tail eating” – consuming a wide variety of proteins from the entire animal.
I personally don’t like the taste of liver and bone broth can be inconvenient to make all the time, so I often supplement with these grass-fed beef liver capsules and drink this high-quality pre-made bone broth.
But if you’re actually interested in learning about how to cook and incorporate more whole animal proteins into your diet, I recommend checking out the book Odd Bits: How to Cook the Rest of the Animal by Jennifer McLagan.
3. Vitamin C
Taking extra Vitamin C is another way to increase IGF-1.
As you probably know, Vitamin C is found in fruits and vegetables such as green peppers, citrus fruits, tomatoes, cauliflower, Brussels sprouts, broccoli, and cabbage.
Researchers have found that higher dietary intake of citrus fruits and Vitamin C is associated with higher concentrations of IGF-1 (1).
Eating lots of fruits and vegetables is a great idea if you want to improve your brain health and cognitive function.
And blueberries are particularly potent because of the flavonoids within them.
I buy wild blueberries every time I go grocery shopping.
They are included in my Free Grocery Shopping Guide for Optimal Brain Health.
Alternatively, you can take a blueberry extract.
I used to take this one. It’s actually cheaper in the long run that eating blueberries every day, but I just prefer eating actual blueberries.
In fact, most researchers often use concentrated blueberry extracts instead of actual blueberries when they study the beneficial health effects of blueberries.
Magnesium is a vital mineral that participates in more than 300 biochemical reactions in your body.
Unfortunately, a lot of people are deficient in magnesium.
This is a shame because magnesium is absolutely essential for optimal brain function.
Research shows that magnesium levels are strongly and independently associated with total IGF-1 levels (14).
Since most people are deficient, magnesium is one of the three supplements that I think everyone should be taking every day.
I personally take this supplement every day for energy, and it includes magnesium.
You should also make sure you’re eating enough magnesium-rich foods on a regular basis, including:
These foods are included in my Free Grocery Shopping Guide for Optimal Mental Health.
Selenium is an essential trace mineral that is important for many bodily processes that affect your brain and mental health.
Studies show that there is a significant association between selenium and IGF-1 levels (16).
Animal research has found that a selenium deficiency is linked to lower IGF-1 levels (17).
And supplementing with selenium has been shown to significantly increase IGF-1 in elderly individuals (18-19).
Cinnamon is a tasty spice that has a number of health benefits.
It has anti-inflammatory effects, it’s loaded with antioxidants, and it's even been shown to have beneficial effects on neurodegenerative diseases, including Alzheimer's disease and Parkinson’s disease (46-49).
Researchers have also found that cinnamon extract significantly activates IGF-1 signaling (50-51).
Not all cinnamon is created equal though.
You’ll have to find and consume Ceylon, which is considered “true cinnamon”. It has the most health benefits.
Most cinnamon in grocery stores is cheap and not actually Ceylon.
You can usually find Ceylon in health food stores.
It’s also available through Amazon.
8. Vitamin D
Vitamin D is a fat-soluble vitamin that your skin synthesizes when exposed to the sun.
Unfortunately, researchers estimate that 50% of people are at risk of Vitamin D deficiency.
This is a huge problem because every tissue in your body has Vitamin D receptors, including the brain, so a deficiency can lead to costly physiological and psychological consequences.
Research shows that Vitamin D significantly increases circulating IGF-1 levels in adults (25).
Ideally, you should get your Vitamin D by going outside and getting sun.
I try to get sunlight every day during the spring and summer months.
But most people still don’t get enough Vitamin D from the sun, especially during the winter.
During the winter months, when there isn't enough sun, I take this Vitamin D3 supplement.
It's important to test and monitor your Vitamin D levels before and after supplementing with it.
You can order an at-home Vitamin D test here.
It’s used in nearly every cell in the body and especially important for supporting energy levels.
Researchers have found that Vitamin B1 plays a key role in the IGF-1 system, and a deficiency leads to a significant drop in IGF-1 levels (27).
Vitamin B1 is included in Optimal Energy.
These foods are included in my Free Grocery Shopping Guide for Optimal Brain Health.
Best Supplements and Herbs to Increase Insulin-Like Growth Factor 1 (IGF-1) Naturally
The beneficial bacteria in your gut are known to convert the food you eat into short-chain fatty acids.
These probiotic bacteria - and the short-chain fatty acids that they produce - play a critical role in the synthesis of IGF-1 in your body and brain.
Research clearly shows that the following probiotics stimulate the IGF-1 system and increase IGF-1 concentrations (33-40).
All four of these probiotics are included in the Optimal Biotics supplement.
Meanwhile, antibiotics have been shown to decrease IGF-1 (41).
Check out this older article for several other ways to increase your good gut bacteria.
And if you struggle with anxiety, here are 9 probiotic strains that can help.
Dehydroepiandrosterone (DHEA) is one of the most abundant circulating steroid hormones in humans. It’s produced in the adrenal glands, the gonads, and the brain, and it’s a precursor to other hormones, including estrogen and testosterone.
It's also available as a supplement.
In one study, a 100 mg daily dose of DHEA for six months elevated IGF-1 levels in both men and women (3).
You can get DHEA here.
It's also one of the best supplements for reducing depression.
Taurine is an organic compound found in food, particularly meat and seafood.
It turns out that it can also increase IGF-1 levels and increase the synthesis of IGF-1 (42-43).
Taurine is included in the Optimal Zinc supplement.
It’s known to help prevent the development of neurodegenerative diseases.
And researchers are starting to understand why.
In one study, resveratrol was shown to improve cognitive function by increasing the production of IGF-1 in the brain (4).
Athletes and bodybuilders often take it as a supplement because it helps increase energy, improve strength and build muscle.
Researchers have found that leucine significantly increases IGF-1 and IGF binding protein (52).
You can get leucine from protein-rich foods, such as fish, chicken and turkey.
But you may want to supplement with it if your goal is to increase IGF-1.
I take this BCAA supplement when I lift weights regularly.
Astragalus is an adaptogenic herb that has been used for centuries by traditional Chinese medicine practitioners to support the immune system and reduce inflammation.
Astragalus membranaceus extract has been shown to significantly increase IGF-1 levels in humans and animals (53-57).
Colostrum is a special kind of milk, also known as “first milk”.
It’s naturally produced by the mammary glands of mammals immediately following the delivery of a newborn.
It contains a number of different nutrients and growth factors, including IGF-1, that support the health and development of a newborn baby (58).
Research shows that colostrum supplementation significantly increases circulating levels of IGF-1 (59-60).
I take this bovine colostrum powder regularly. I would say it's probably the most important supplement I've taken to optimize my IGF-1 levels.
It’s been shown to have neuroprotective and cognitive-enhancing effects. It’s often used as a natural brain booster because it increases alertness and provides support to brain cells.
It does so much, so not surprisingly, researchers have also found that ALCAR increases IGF-1 levels in humans (20).
Animal studies also show that it increases IGF-1 levels in rats (21-22).
I find that ALCAR personally gives me a big boost in mental energy and cognitive function.
That’s why it’s included in the Optimal Brain supplement.
Creatine is a molecule produced in the body and found in some foods, particularly meat, eggs, and fish.
Creatine is also available as a supplement. Athletes, bodybuilders, wrestlers, sprinters often take extra creatine to gain more muscle mass. It’s an incredibly well-researched supplement and safe to take regularly.
In one study, healthy individuals took creatine every day for 5 days, and researchers witnessed a 30 per cent increase in IGF expression (24).
19. Ursolic Acid
In one study, supplementing with 100 mg of Ursolic Acid, three times daily, increased IGF-1 levels in humans by 22.8 per cent (62).
Animal research also shows that it increases IGF-1 signaling and enhances IGF-1 receptors (61, 63).
You can get pure Ursolic Acid through Amazon.
20. Hydroxy Methyl Butyrate
Hydroxy Methyl Butyrate (HMB) is a metabolite of leucine.
It's also a dietary supplement used by athletes and bodybuilders to increase muscle strength and development.
Studies show that HMB supplementation increases the expression and levels of IGF-1 (64-65).
You can get HMB through Amazon.
21. Coenzyme Q10
Research shows that supplementing with CoQ10 significantly increases IGF-1 levels (26).
CoQ10 is included in Optimal Energy.
Best Lifestyle Habits, Therapies and Practices to Increase Insulin-Like Growth Factor 1 (IGF-1) Naturally
22. Low-Level Laser Therapy
Several studies show that LLLT increases the expression, production and release of IGF-1 (28-32).
I previously wrote about my experience with low-level laser therapy here.
I use this device and shine the red and infrared light directly on my forehead.
I also use the Vielight 810, which is an intranasal device with 810 nm of near infrared light (If you decide to try one of the Vielight devices, you can use the coupon code JORDANFALLIS for a 10% discount).
Exercise is probably the best way to boost IGF-1 levels, as it also appears to “push” IGF-1 to the brain to improve its function.
There are two main forms of exercise that you need to engage in if you want to increase your IGF-1 levels – high-intensity interval training (HIIT) and resistance training.
Research shows that resistance training (also known as strength training or weight training) significantly increases IGF-1 and increases the bioavailability of IGF-1 (73).
Intense and strenuous HIIT workouts cause a significant increase in circulating levels of IGF-1 (74).
That’s why many doctors and researchers recommend exercise as their number one piece of advice for optimal brain health.
24. Deep Sleep
Getting enough high-quality, deep sleep is very important if you want to increase your IGF-1 levels and improve your brain and mental health.
I used to have very poor sleep and it was one of the main factors that contributed to my low IGF-1 levels and poor cognitive function.
Sleep deprivation is known to suppress IGF-1 in humans and animals (75, 78-79).
Meanwhile, sleep extension significantly increases IGF-I concentrations (76).
In one study, researchers found that increased deep sleep is associated with higher levels of IGF-1 in healthy older men (77).
So, it’s not just the length of your sleep that matters.
It’s also the depth and quality of your sleep.
If you’re having trouble with sleep, try this sleep supplement. It contains magnesium and other natural compounds that I’ve used over the years to promote deeper and more restful sleep.
25. Reduce Inflammation
Reducing inflammation throughout your entire body is a key step towards increasing your IGF-1 levels naturally.
Research clearly shows that proinflammatory cytokines inhibit and impair IGF-1 bioactivity, and induce a state of IGF resistance (81-85).
There are many causes of chronic inflammation, including infections, mold, brain injuries, and leaky brain.
But one of the most common causes – and the one you have the most control over – is your diet.
That’s why I recommend following an anti-inflammatory diet and avoiding foods such as gluten and dairy that can trigger inflammation in the gut and brain.
You should also remove processed food from your diet, and increase your intake of vegetables, fruits, wild fish, grass-fed beef and organic chicken.
Check out my Free Grocery Shopping Guide for Optimal Brain and Mental Health for a full list of anti-inflammatory foods.
26. Avoid or Limit Alcohol
It also lowers your IGF-1 levels.
Researchers have found that high alcohol intake inhibits IGF-1 (86).
There are ways to protect your brain from alcohol, but you’re better off avoiding it completely or significantly reducing your consumption if you’re trying to heal. I personally don’t drink alcohol at all anymore.
If you do decide to drink it, this post explains that some types of alcohol are better than others.
27. Sauna Sessions
When it comes to improving your health, some of the simplest strategies can have a huge impact.
Using a sauna regularly is one of them.
Research suggests that daily sauna sessions can significantly increase the production of growth hormone and IGF-1 (44-45).
This sauna is the best low-EMF, infrared sauna on the market.
Once you start using a sauna, you should listen to your body to determine how much time you should spend in it. Start out slowly and increase the length of your sessions over time.
Also, make sure to drink lots of water before and after each session, and never consume alcohol in combination.
Check out this post to learn more about saunas and the 13 ways they can improve your brain and mental health.
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Medically reviewed by Dr. Fred Hui, MD, CCFP, CAFC