29 Effective Ways to Increase Oxytocin Levels in the Brain

Man and woman kissing and increasing their oxytocin levels.

Oxytocin is a powerful hormone and neurotransmitter.

It’s often called the “love hormone" or “cuddle chemical” because it plays a key role in the emotional bond between a mother and her child.

It’s also released by both men and women when they are in love (116-118). 

But it isn’t just involved in loving relationships. 

It can also significantly affect the functioning of your brain and nervous system and impact your emotions day-to-day.

Low levels of oxytocin in the brain are associated with several mental health conditions, including depression, anxiety, social phobia, autism, schizophrenia, post-traumatic stress disorder, tinnitus, anorexia nervosa, and borderline personality disorder (120-135). 

And research suggests that if you increase oxytocin, it can lead to the following benefits:

Oxytocin clearly does a lot. 

Because of this, some doctors have started prescribing intranasal oxytocin spray to their patients to help them treat their symptoms (119). 

But you don’t necessarily need to run to your doctor and ask for a prescription. 

You can follow the 29 steps below and naturally increase your oxytocin levels yourself.

 

The Best Foods, Nutrients, Herbs and Supplements To Naturally Increase Oxytocin Levels in the Brain

1. Vitamin D

Vitamin D is a fat-soluble vitamin that your skin synthesizes when exposed to the sun. It can also be taken as a supplement.

Picture of the sun. The sun produces Vitamin D, which increases oxytocin levels in the brain.

Every tissue in your body has Vitamin D receptors, including the brain, so a deficiency can lead to costly physiological and psychological consequences.

Research shows that oxytocin is directly activated and controlled by Vitamin D (13-14).

Some researchers also believe that autistic children have low levels of oxytocin likely because they are deficient in Vitamin D (15-16). 

Ideally, you should get your Vitamin D naturally from the sun. 

It’s especially important to make sure you get some sunlight in the morning to set your circadian rhythm. 

But most people still don’t get enough Vitamin D from the sun, and that’s why I recommend taking a Vitamin D supplement or using a Vitamin D lamp.

Researchers estimate that 50 percent of the general population is at risk of Vitamin D deficiency (12). 

It's important to test and monitor your Vitamin D levels before and after supplementing with it.

Vitamin D also naturally increases dopamine levels in the brain, and being deficient in Vitamin D can make you more anxious and more depressed

 

2. Vitamin C

Vitamin C is another easy way to optimize and increase your levels of oxytocin. 

Researchers know that Vitamin C is a cofactor in the production of oxytocin, and the synthesis of oxytocin is dependent upon Vitamin C (17-18). 

One study found that Vitamin C stimulates the secretion of oxytocin (19). 

And another study found that supplementing with a high dose of Vitamin C increases the release of oxytocin, which then increases intercourse frequency, improves mood and decreases stress (20). 

As you probably know, Vitamin C is found in fruits and vegetables such as green peppers, citrus fruits, tomatoes, cauliflower, Brussels sprouts, broccoli, and cabbage.

In addition to getting Vitamin C from fruits and vegetables, I take a supplement with some Vitamin C.

I’ve taken up to 10 grams daily, and it definitely improves my mood and reduces stress and anxiety

Vitamin C is included in this supplement.

 

3. Magnesium

Magnesium is a vital mineral that participates in more than 300 biochemical reactions in your body. 

Unfortunately, lot of people are deficient in magnesium today (36-38).

A collection of magnesium-rich foods, including avocados, bananas, almonds, dark chocolate, spinach. Magnesium increases oxytocin levels in the brain.

This is a shame because magnesium is absolutely essential for the proper functioning of your nervous system and optimal neurotransmitter activity.

Researchers have found that the oxytocin receptor requires magnesium to function properly, and magnesium increases the action of oxytocin at the receptor (39-42).

There are a number of things you can do to make sure you’re getting enough magnesium.

First, make sure you’re eating magnesium-rich sources of food on a regular basis, including spinach, chard, pumpkin seeds, almonds, avocado, dark chocolate and bananas. These foods are included in my Free Grocery Shopping Guide for Optimal Mental Health.

Epsom salt baths are another great way to increase your body’s intake of magnesium

Magnesium supplements are also a good idea if you want to produce more oxytocin.

Magnesium is included in this supplement.

Besides supporting your oxytocin levels, magnesium can also naturally increase dopamine, reduce your anxiety, and help your overcome trauma, withdrawal and addiction

 

4. Taurine

Taurine is an organic compound found in food, particularly animal products. It has a wide variety of health benefits.

It can cross the blood-brain barrier, improve mood and produces anti-anxiety effects (1-10). 

Researchers believe that one of the ways it improves mood and reduces anxiety is by naturally increasing the release of oxytocin in the brain (11).

Taurine is included in the Optimal Calm supplement

Click here to subscribe

5. Caffeine

Researchers have found that caffeine significantly increases the release of oxytocin (21-23). 

Perhaps this is one reason why people love getting together with friends for a coffee.

Coffee usually makes me sick because I’m extremely sensitive to mold and most coffee contains high amounts of mycotoxins (toxic metabolites produced by mold). 

But some coffee doesn’t. I usually drink one cup of high-quality coffee most mornings. I can also tolerate pure caffeine tablets.

Most people can tolerate regular coffee just fine. But if coffee makes you feel terrible and jittery, it might be the quality of the coffee. Consider trying higher-quality coffee, or simply take pure caffeine, and see how you feel. You’ll likely feel better than if you consumed low-quality coffee.

Coffee and caffeine can disrupt sleep though, so make sure you don’t drink it later in the day. I have my last cup sometime between 10 in the morning and noon. If I have it any later than that, it disrupts my sleep.

Lastly, it's also a good idea to try to consume the whole coffee fruit, instead of just the coffee bean or pure caffeine. 

Traditionally, the coffee bean is extracted from the coffee fruit for roasting. And the surrounding fruit is discarded. 

But that’s a huge problem.

Because the coffee fruit contains several healthy compounds not found in coffee beans themselves.

And after years of careful clinical research, scientists have discovered that ingesting whole coffee fruit concentrate significantly increases brain function

Coffee fruit concentrate is included in the Optimal Brain supplement

 

6. Estrogen

Estrogen is the primary female sex hormone and responsible for the development and regulation of the female reproductive system.

Estrogen has been found to increase the synthesis and secretion of oxytocin. It also increases the expression of oxytocin receptors in the brain (30). 

Other studies show that even just a single dose of estradiol can significantly increase circulating oxytocin levels and reduce anxiety (31-32).

I recommend both men and women get their hormone levels checked regularly, and then optimize them with hormone replacement therapy, especially if they want to produce more oxytocin and feel their best.

Not only can replacing estrogen increase your oxytocin levels, but it can also really improve your overall quality of life.

 

7. Lactobacillus Reuteri

Lactobacillus reuteri is a bacterium with anti-inflammatory effects that scientists first discovered in the 1980s. 

It’s one of the most promising psychobiotics for anxiety.

A woman holds her stomach and makes a heart shape around her belly button.

Research shows that Lactobacillus reuteri significantly increases oxytocin levels in the brain through the vagus nerve (26-29). 

Lactobacillus reuteri is usually found in the human gut. However, not all humans have it, and some people simply have very low levels of it.

Therefore, you may need to supplement with it to introduce and maintain high levels of it, especially if you want to produce more oxytocin.

One study found that the absence of lactobacillus reuteri causes social deficits in animals. By adding it back in to the guts of the animals, the researchers were able to reverse some of their behavioural deficits, which were similar to symptoms of social anxiety and autism in humans (24-25).

Lactobacillus reuteri is included in the Optimal Biotics supplement.

It's also found in breast milk, and some meat and dairy products.

 

8. Chamomile

You can also increase oxytocin with herbs, such as chamomile.

Chamomile is a medicinal herb that has been traditionally used for its calming and anti-inflammatory properties.

But it can also help you produce more oxytocin.

Animal studies show that chamomile contains substances that act on the same parts of the brain and nervous system as anti-anxiety drugs (47-48). 

Researchers also know that chamomile naturally increases oxytocin and lowers cortisol (49). 

 

9. Oleoylethanolamide (OEA)

Oleoylethanolamide (OEA) is a molecule produced in the body. It’s responsible for the feeling of being full after meals and may help with weight loss.

Multiple studies show that OEA naturally stimulates the secretion of oxytocin and increases levels of oxytocin in the brain (50-54). 

I haven’t tried it yet, but there are OEA supplements available online.

I’m going to try it and report back on how I feel. We’ll see if it helps me produce more oxytocin.  

 

10. Melatonin

Melatonin is a natural hormone released by your pineal gland, a small gland in your brain. It helps control your sleep and wake cycles (circadian rhythm), and adequate levels of melatonin are necessary to fall asleep quickly and sleep deeply throughout the night.

More than one study has shown that 500 mcg of melatonin significantly increases secretion of oxytocin (33-35). 

You can find supplements with 500 mcg of melatonin online.

A baby sleeping. Sleep increases oxytocin levels in the brain.

Or you can take this sleep supplement, which contains magnesium and a number of other natural compounds that I’ve used over the years to promote the production of melatonin.

Besides melatonin and sleep supplements, there are a number of other actions you can take to naturally produce more melatonin.

I work with my clients so that they can naturally produce more melatonin and maximize the quality of their sleep without so many supplements. We have free online workshop that talks about how you can work with us. You can register for the workshop here.

Click here to subscribe

11. Fenugreek

Fenugreek is one of the most popular herbal supplements that has been traditionally used to enhance sex drive. 

It also demonstrates antidepressant and anti-anxiety effects in animals, and naturally produces more oxytocin in humans (55-57). 

I once experimented with a fenugreek supplement and I liked the effects. It felt like I produced more oxytocin when I was taking it, but I no longer take it regularly because all my other lifestyle habits are more than enough.

Fenugreek seeds are another option. They can be eaten whole, brewed into a tea, or even made into flour and baked into a gluten-free bread.

 

12. Jasmine Oil (Jasminum Officinale)

Jasmine Oil is a popular essential oil derived from the Jasminum Officinale flower. 

It’s been used for hundreds of years in Asia to improve mood, manage emotional stress and anxiety, and improve sex drive and sleep.

There is lots of research that suggests that it has positive affects on the nervous system (59-62). 

And a systematic study found that aromatherapy with Jasmine Oil can increase levels of oxytocin (58). 

After living in a moldy home, I researched and experimented with a number of essential oils. I found they supported my immune system and mood as I recovered. Here is the Jasmine Oil that I took.

It can either be inhaled through the nose or applied directly to the skin. You can also diffuse it in your home using a diffuser. 

 

13. Clary Sage Oil (Salvia sclarea)

Clary Sage Oil is a relaxing essential oil derived from the Salvia sclarea plant. 

Clary Sage essential oil increases oxytocin levels in the brain.

It’s been shown to naturally relieve anxiety and depression by reducing cortisol and improving thyroid hormone levels (63-66). 

And just last year, researchers found that inhaling Clary Sage Oil increases oxytocin in women during pregnancy (67-69). 

After living in a moldy home, I researched and experimented with a number of essential oils. I found they supported my immune system and mood as I recovered.

Just like Jasmine Oil, it can either be inhaled through the nose or applied directly to the skin. You can also diffuse it in your home using a diffuser.

 

14. Anise Seed (Pimpinella anisum)

Anise, also known as Pimpinella anisum, is a plant found in the same family as carrots, celery and parsley.

The plant produces a small white fruit called anise seed.

It’s rich in nutrients and can be used a natural remedy for a number of different health concerns.

Research shows that anise seed can increase oxytocin in pregnant women (183).

In one study, it was effective reducing symptoms of postpartum depression (184).

But it doesn’t just work in new mothers who have postpartum depression.

Another study showed that taking anise oil can decrease depressive symptoms in men and women with mild to moderate depression (185).

Anise seed can be taken by adding it to desserts and drinks.

Or you can use anise oil like they did in the depression study above.

 

The Best Lifestyle Habits, Therapies and Practices to Naturally Increase Oxytocin Levels in the Brain

15. Touch

Not surprisingly, there is a ton of research showing that interpersonal touch quickly increases oxytocin levels in the brain (107). 

This obviously includes kissing, cuddling, and sex. But non-sexual touch such as hugging and shaking hands increases oxytocin as well (105, 108-115).

A 10-second hug every day can help boost your immune system, fight infection, increase dopamine, reduce depression, and lessen fatigue (106). 

But Dr. Paul Zak, author of the Trust Factor, recommends much more than just one hug every day; he recommends eight hugs every day. 

So if you want to produce more oxytocin, get out there and start hugging people… just make sure it’s welcome by the other people. :)

 

16. Loving-Kindness Meditation

Loving-kindness meditation, or metta, is a meditation practice designed to enhance feelings of kindness and compassion for yourself and others.

While meditating, you repeat positive phrases to yourself, think positively of other people, and direct well-wishes and love towards them.

For example, you could close your eyes, simply think about a friend of family member, and repeat over and over that “they are wonderful”. Simply repeat this thought to yourself over and over, while pushing away any other negative thoughts that arise.

Researchers believe that you give yourself a boost in oxytocin when you do this and may even up-regulate oxytocin receptors (71). 

You can learn how to practice it here or through this video.

Loving-kindness meditation can also help you overcome trauma

Click here to subscribe

17. Acupuncture

Acupuncture is an alternative treatment that has been shown to increase oxytocin levels (76). 

Research has shown that acupuncture can affect the synthesis, release and action of several neurotransmitters and neuropeptides, including oxytocin (72). 

Animal studies have also demonstrated that acupuncture elevates oxytocin concentration in certain brain regions (73-75). 

I’m a really big fan of auricular acupuncture for producing more oxytocin. Auricular acupuncture is when needles are inserted into ear. I’d recommend trying to find a health practitioner in your area who provides it, especially if you’re weening off psychiatric medication. It really helped me the first time I came off antidepressants. I was surprised.

In my experience, ear acupuncture is more effective than regular acupuncture. I’m not sure why. I’ve just personally noticed more benefits from ear acupuncture. 

I also use an acupuncture mat at home to relax before bed.

Acupuncture also naturally increases dopamine, stimulates the vagus nerve and increases blood flow to the brain.

 

18. Pets

A cute puppy lying on a couch. Pets increase oxytocin levels in our brains.

Animals have a way of calming us, and it’s because they increase our oxytocin levels. 

Research shows that just touching your pets lowers your blood pressure and increases your oxytocin levels.

One study found that oxytocin levels increased in both humans and dogs after just five minutes of petting. This may explain the emotional bonding between humans and dogs (77). 

Even just staring into your dog’s eyes can trigger the release of oxytocin in the brain and increase your levels (78). 

So if you’re trying to maximize your oxytocin levels, you should try to hang out with animals as much as possible, and consider getting a house pet if you don’t have one.

 

19. Massage

Research shows that massage can significantly increase oxytocin levels and reduce stress hormones (79, 83). 

This is why I personally get a massage from a registered massage therapist every couple of months. 

It’s important to note that one study found that a light massage is more effective at increasing oxytocin than a deep-tissue Swedish massage (80-82). 

So you may want to ask your massage therapist to take it easy and give you a gentle rubdown. 

 

20. Listen to Music and Sing

Music is actually healing and can have a calming effect on the brain by increasing oxytocin levels. 

A woman singing with a microphone. Singing increases oxytocin levels.

In one study, patients who underwent open-heart surgery listened to soothing music for 30 minutes one day after their surgery. And they had significantly higher levels of oxytocin compared to those who were simply told to rest in bed (86).

Slow-tempo music has also been shown to increase both oxytocin and heart-rate variability (88). 

What’s even better is singing along with the music. 

Researchers have found that singing for 30 minutes significantly increases oxytocin levels in both amateur and professional singers, regardless of whether they enjoyed singing the song (87, 91).

Perhaps this explains why mothers often sing lullabies to their newborn babies – it may encourage bonding by increasing the release of oxytocin. 

Lastly, making music together in a group leads to a significant release in oxytocin and reduction in stress (89-90).

So if you play an instrument, put together a band and start jamming. You’ll started producing more oxytocin together! :)

 

21. Yoga

Yoga is a popular “mind-body” relaxation technique that increases the activity of your parasympathetic “rest and digest” nervous system.

Researchers believe it works because it increases oxytocin levels in the brain by stimulating the vagus nerve (85). 

In one study, researchers found that yoga significantly increased oxytocin levels and improved socio-occupational functioning in patients with schizophrenia. The researchers concluded that yoga should be used to manage schizophrenia because of the improvement in oxytocin levels (84). 

Click here to subscribe

22. Socialize

I’ve already discussed how socializing can reduce cortisol and stimulate your vagus nerve

And now I’ve learned that positive social interactions can also increase oxytocin levels (93). 

Researchers have found that your brain releases more oxytocin during social contact and social bonding, and this can actually speed up healing from disease (92). 

So if you want to produce more oxytocin, my advice is to talk to people whenever you get the chance, and hang out with your friends and family as much as possible. I should probably be taking my own advice here because I’m an introvert and don’t socialize too much. 

But even just connecting through social media can increase oxytocin! It doesn’t necessarily need to be in person, although that’s definitely better.

 

23. Intermittent Drinking

You’ve probably heard of intermittent fasting. I’ve discussed it a lot in other articles. 

But you likely haven’t heard of intermittent drinking.

The typical mainstream advice is to drink eight glasses of water every day. 

A blond-haired woman drinking a glass of water. Intermittent drinking increases oxytocin levels in the brain.

I don’t follow that. I simply listen to my body and drink when I’m thirsty. 

And it appears that simply taking breaks from drinking water can increase oxytocin levels. 

Recent research shows that drought, and the “homeostatic disturbances” that lead to the “feeling of thirst”, activate specific oxytocin-producing parts of the brain (94-95). 

Researchers believe that “intermittent bulk drinking” could increase oxytocin signalling, recover human trust, and increase health by reducing stress and inflammation (94-95). 

If you think of it from an evolutionary perspective, this makes sense. Your ancestors likely consumed as much water as they could when they got the chance, but then went longer periods of time when they couldn’t and didn’t drink any water. 

Just like intermittent fasting, intermittent drinking doesn’t necessarily mean you drink less water throughout the day though.

You can simply drink a lot of water whenever you get thirsty. And then you stop drinking any water until you are thirsty again. 

That’s how all animals and human newborns behave. But we’ve been brainwashed to think we need to be sipping on water all the time. 

Start intermittent drinking, and your oxytocin receptors will thank you.

 

24. Warm and Cold Temperatures

Exposing yourself to both warm and cold temperatures can also increase oxytocin levels. 

Researchers have found that hot environments, warm temperatures and increased sweating activate specific oxytocin-producing parts of the brain (94-96). 

Giving birth in warm water has also been shown to reduce the need for doctors to give women synthetic oxytocin during labour. This suggests the warm water naturally increases oxytocin levels (186).

But it’s not just warm water and warm temperatures that increase oxytocin.

Recent research also suggests that cold exposure significantly upregulates oxytocin levels in the brain (97-100). 

So if you want to optimize your oxytocin levels, try pushing yourself outside your comfort zone and expose your body to the acute stress of extreme temperatures.

What I like to do is take a warm shower, but then finish it off with 1-2 minutes of cold. 

Cold showers also stimulate the vagus nerve

 

25. Eat (Healthy) Food

Eating food also increases oxytocin, and it’s easily accessible by anyone. 

Food activates touch receptors in your mouth, which then stimulates the release of oxytocin (102). 

And then when food reaches your gut, a hormone is released from the intestines that activates the vagus nerve, which then stimulates the release of more oxytocin in the brain (102-104). 

This is why eating makes people feel calm and satisfied, and often opens them up for social interaction, bonding and attachment.

The obvious downside to all of this is that you may be tempted to overeat unhealthy foods to stimulate the release of oxytocin, so that you feel better and less stressed. And oxytocin is one reason why you may have a hard time breaking bad eating habits. 

But don’t worry; just stick to the healthy foods included in my free grocery shopping guide and you won’t have a problem

 

26. Watch a Movie

Everyone loves a good movie.

And it’s probably because it increases oxytocin.

Research shows that compelling narratives cause the synthesis and release of oxytocin (101). 

And this has the power to affect our attitudes, beliefs, and behaviours (101). 

 

27. Give Someone A Gift

Everyone loves receiving a gift.

But it turns out that giving someone a gift benefits you, the gift-giver, as well.

Studies show that receiving and giving gifts increasing oxytocin levels in the brain.

 

28. Hypnosis

Hypnosis - also known as hypnotherapy or hypnotic suggestion - is a trance-like state.

When you’re in this state, you have heightened focus and concentration, and reduced peripheral awareness.

You’ll also have an enhanced capacity to respond to suggestion.

Hypnosis is usually done with the help of a therapist using verbal repetition and mental images.

Researchers believe that the benefits of hypnosis may be due to its oxytocin-increasing effects (182).

 

29. Volunteer

Volunteering is another excellent way to boost your own oxytocin.

A study published in the journal Hormones and Behavior found that charitable behaviour reduces stress and improves health by increasing oxytocin levels (187).

So get out there and volunteer at your local food bank already!

 

Enjoy This Article? You Might Also Like My FREE Food Guide for Optimal Brain and Mental Health!

Click here to subscribe

Live Optimally,

Jordan Fallis

Connect with me

References:

(1) https://www.ncbi.nlm.nih.gov/pubmed/4407108

(2) https://www.ncbi.nlm.nih.gov/pubmed/8915375

(3) https://link.springer.com/article/10.1007%2Fs00210-003-0776-6

(4) https://www.ncbi.nlm.nih.gov/pubmed/1846756

(5) https://www.ncbi.nlm.nih.gov/pubmed/11598776

(6) https://www.ncbi.nlm.nih.gov/pubmed/18676123

(7) https://www.ncbi.nlm.nih.gov/pubmed/18823590

(8) https://www.ncbi.nlm.nih.gov/pubmed/16540157

(9) https://www.karger.com/Article/Abstract/107687

(10) https://www.ncbi.nlm.nih.gov/pubmed/15240184

(11) https://www.ncbi.nlm.nih.gov/pubmed/14552874

(12) https://goo.gl/RxZ2VQ

(13) https://www.sciencedaily.com/releases/2014/02/140226110836.htm

(14) https://www.ncbi.nlm.nih.gov/pubmed/24558199

(15) https://goo.gl/o3CDSc

(16) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848704/

(17) https://examine.com/supplements/vitamin-c/

(18) https://en.wikipedia.org/wiki/Oxytocin

(19) https://www.ncbi.nlm.nih.gov/pubmed/3668432

(20) https://www.ncbi.nlm.nih.gov/pubmed/12208645

(21) https://www.nature.com/articles/ncomms15904

(22) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490268/

(23) https://www.ncbi.nlm.nih.gov/pubmed/28654087

(24) https://www.sciencedaily.com/releases/2016/06/160616140723.htm

(25) http://www.cell.com/cell/fulltext/S0092-8674(16)30730-9

(26) https://examine.com/supplements/lactobacillus-reuteri/#summary9-1

(27) http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078898

(28) https://www.ncbi.nlm.nih.gov/pubmed/27793228

(29) https://www.sciencedaily.com/releases/2016/06/160616140723.htm

(30) https://en.wikipedia.org/wiki/Oxytocin

(31) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606117/

(32) https://www.ncbi.nlm.nih.gov/pubmed/1943752/

(33) https://www.ncbi.nlm.nih.gov/pubmed/12390335

(34) https://www.ncbi.nlm.nih.gov/pubmed/10594526

(35) https://www.ncbi.nlm.nih.gov/pubmed/9594418

(36) http://www.tandfonline.com/doi/abs/10.1080/00048670802534408

(37) http://www.ncbi.nlm.nih.gov/pubmed/10746516

(38) http://www.ncbi.nlm.nih.gov/pubmed/9861593

(39) http://en.wikipedia.org/wiki/Oxytocin

(40) https://www.sciencedirect.com/science/article/pii/001429996890191X

(41) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1135623/

(42) https://www.ncbi.nlm.nih.gov/m/pubmed/2539090/

(43) http://en.wikipedia.org/wiki/Oxytocin

(44) https://www.ncbi.nlm.nih.gov/pubmed/10795905

(45) https://www.ncbi.nlm.nih.gov/pubmed/12175921

(46) https://www.ncbi.nlm.nih.gov/pubmed/12436925

(47) https://www.herbwisdom.com/herb-chamomile.html

(48) https://www.ncbi.nlm.nih.gov/pubmed/21601431

(49) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301993/

(50) https://www.hindawi.com/journals/bmri/2014/203425/

(51) https://www.ncbi.nlm.nih.gov/pubmed/20554860

(52) https://www.ncbi.nlm.nih.gov/pubmed/23959001

(53) https://www.ncbi.nlm.nih.gov/pubmed/20554860

(54) https://www.sciencedirect.com/science/article/abs/pii/S0196978113002775

(55) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745208/

(56) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561638/

(57) https://goo.gl/Vg5Ymn

(58) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280734/

(59) https://www.ncbi.nlm.nih.gov/pubmed/20184043

(60) https://www.ncbi.nlm.nih.gov/pubmed/15976995

(61) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2529395/

(62) https://goo.gl/AXFGpj

(63) https://www.ncbi.nlm.nih.gov/pubmed/20441789

(64) https://www.ncbi.nlm.nih.gov/pubmed/24802524

(65) https://www.sciencedirect.com/science/article/pii/S0378874110002667

(66) http://online.liebertpub.com/doi/abs/10.1089/jmf.2012.0137

(67) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721455/

(68) https://www.ncbi.nlm.nih.gov/m/pubmed/29216912/

(69) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280734/

(70) https://www.ncbi.nlm.nih.gov/pubmed/7128545

(71) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325657/

(72) https://academic.oup.com/qjmed/article/107/5/341/1563714 \

(73) http://www.acupuncture.com.au/articles/viewarticle.html?id=119

(74) https://www.sciencedirect.com/science/article/pii/S0143417907000522

(75) https://www.ncbi.nlm.nih.gov/pubmed/17664006

(76) http://aim.bmj.com/content/acupmed/20/2-3/109.full.pdf

(77) https://www.ncbi.nlm.nih.gov/pubmed/12672376

(78) http://science.sciencemag.org/content/348/6232/333

(79) https://www.ncbi.nlm.nih.gov/pubmed/23251939

(80) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107905/

(81) http://online.liebertpub.com/doi/abs/10.1089/acm.2009.0634

(82) http://www.nytimes.com/2010/09/21/health/research/21regimens.html

(83) https://www.ncbi.nlm.nih.gov/pubmed/22775448

(84) https://www.ncbi.nlm.nih.gov/pubmed/24049210

(85) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573542/

(86) https://www.ncbi.nlm.nih.gov/pubmed/19583647

(87) https://www.ncbi.nlm.nih.gov/pubmed/12814197

(88) http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0189075

(89) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179700/

(90) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585277/

(91) https://www.nhttps://www.ncbi.nlm.nih.gov/pubmed/12814197bi.nlm.nih.gov/pubmed/12814197

(92) https://www.ncbi.nlm.nih.gov/pubmed/15219651

(93) https://en.wikipedia.org/wiki/Oxytocin

(94) https://goo.gl/CerXB2

(95) https://www.ncbi.nlm.nih.gov/pubmed/27241263

(96) https://www.ncbi.nlm.nih.gov/pubmed/9924739 \

(97) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768886/

(98) https://www.ncbi.nlm.nih.gov/pubmed/29375393

(99) https://www.ncbi.nlm.nih.gov/pubmed/20536333

(100) https://www.ncbi.nlm.nih.gov/pubmed/24002032

(101) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445577/

(102) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4290532/

(103) https://www.ncbi.nlm.nih.gov/pubmed/12113268/

(104) https://www.ncbi.nlm.nih.gov/pubmed/7938364/

(105) http://en.wikipedia.org/wiki/Oxytocin

(106) https://goo.gl/B98Sbu

(107) https://www.ncbi.nlm.nih.gov/pubmed/9924739

(108) https://www.ncbi.nlm.nih.gov/pubmed/8135652/

(109) https://www.ncbi.nlm.nih.gov/pubmed/3782434/

(110) https://goo.gl/2noghs

(111) https://www.ncbi.nlm.nih.gov/pubmed/9949283

(112) https://www.ncbi.nlm.nih.gov/pubmed/8586300

(113) https://www.ncbi.nlm.nih.gov/pubmed/3654918

(114) https://www.ncbi.nlm.nih.gov/pubmed/12697037

(115) https://www.ncbi.nlm.nih.gov/pubmed/15740822

(116) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606117/

(117) https://www.medicalnewstoday.com/articles/275795.php

(118) https://en.wikipedia.org/wiki/Oxytocin

(119) http://www.apa.org/monitor/2011/03/oxytocin.aspx

(120) https://goo.gl/dnqno9

(121) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120070/

(122) https://www.ncbi.nlm.nih.gov/pubmed/25025656

(123) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705963/

(124) https://www.ncbi.nlm.nih.gov/pubmed/19777562

(125) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400019/

(126) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402118/

(127) https://www.ncbi.nlm.nih.gov/pubmed/25262417

(128) https://www.ncbi.nlm.nih.gov/pubmed/23007624

(129) https://www.nature.com/articles/4001911

(130) https://www.ncbi.nlm.nih.gov/pubmed/29049935

(131) https://www.sciencedirect.com/science/article/pii/S0924933817301761

(132) https://www.ncbi.nlm.nih.gov/pubmed/24115458

(133) https://www.ncbi.nlm.nih.gov/pubmed/28983279

(134) https://www.medicalnewstoday.com/articles/275795.php

(135) http://www.sciencedirect.com/science/article/pii/S1550413107000691%20

(136) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606117/

(137) https://www.ncbi.nlm.nih.gov/pubmed/16339042

(138) https://www.ncbi.nlm.nih.gov/pubmed/15821089

(139) https://www.ncbi.nlm.nih.gov/pubmed/21719680

(140) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1621060/

(141) https://www.ncbi.nlm.nih.gov/pubmed/14675803

(142) https://www.ncbi.nlm.nih.gov/pubmed/25262417

(143) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325657/

(144) http://aim.bmj.com/content/acupmed/20/2-3/109.full.pdf

(145) http://www.ncbi.nlm.nih.gov/pubmed/15219651

(146) http://en.wikipedia.org/wiki/Oxytocin

(147) http://www.ncbi.nlm.nih.gov/pubmed/17617382

(148) https://goo.gl/pF8mSP

(149) http://www.sciencedirect.com/science/article/pii/S1550413107000691

(150) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606117/

(151) https://www.ncbi.nlm.nih.gov/pubmed/23007624

(152) https://www.ncbi.nlm.nih.gov/pubmed/25025656

(153) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1621060/

(154) https://www.ncbi.nlm.nih.gov/pubmed/14675803

(155) https://www.ncbi.nlm.nih.gov/pubmed/25262417

(156) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573542/

(157) http://en.wikipedia.org/wiki/Oxytocin

(158) https://en.wikipedia.org/wiki/Oxytocin

(159) https://www.ncbi.nlm.nih.gov/pubmed/3223304

(160) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325657/

(161) http://aim.bmj.com/content/acupmed/20/2-3/109.full.pdf

(162) https://en.wikipedia.org/wiki/Oxytocin

(163) https://www.sciencedirect.com/science/article/pii/S235228951530031X

(164) http://www.ncbi.nlm.nih.gov/pubmed/15219651

(165) https://www.sciencedirect.com/science/article/pii/S235228951530031X

(166) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888874/

(167) http://www.ncbi.nlm.nih.gov/pubmed/15219651

(168) http://en.wikipedia.org/wiki/Oxytocin

(169) https://www.ncbi.nlm.nih.gov/pubmed/26267407

(170) http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044014

(171) http://www.journalvetbehavior.com/article/S1558-7878(14)00176-2/abstract

(172) http://aim.bmj.com/content/acupmed/20/2-3/109.full.pdf

(173) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276444/

(174) https://www.ncbi.nlm.nih.gov/pubmed/9924746

(175) https://www.ncbi.nlm.nih.gov/pubmed/24056025

(176) http://en.wikipedia.org/wiki/Oxytocin

(177) https://www.sciencedaily.com/releases/2015/10/151026171805.htm

(178) https://www.medicalnewstoday.com/articles/275795.php

(179) https://www.ncbi.nlm.nih.gov/pubmed/22012170%20

(180) https://www.ncbi.nlm.nih.gov/pubmed/22012170%20

(181) http://en.wikipedia.org/wiki/Oxytocin

(182) https://www.ncbi.nlm.nih.gov/pubmed/9924739

(183) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561638/

(184) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354059/

(185) https://www.ncbi.nlm.nih.gov/pubmed/26873392

(186) https://www.bmj.com/content/328/7435/314.full

(187) https://www.sciencedirect.com/science/article/abs/pii/S0018506X13000202

Terms and Conditions

Privacy Policy

Affiliate Disclosure

Disclaimer

28 Powerful Ways to Increase Your IGF-1 Levels

Insulin-like growth factor 1 (IGF-1) is a hormone in your body that’s absolutely critical for optimal physical and mental performance.  

It’s produced by the liver.

And once it’s released into the bloodstream, it stimulates growth, regenerates cells, and helps your body recover and repair itself.  

It’s known to play an important role in childhood growth and development, and helps you build and maintain muscle throughout your entire adult life.  

But it doesn’t just affect your muscles… 

It also powerfully supports your brain. 

Unfortunately, your IGF-1 levels drastically decrease as you get older, contributing to cognitive decline

Your levels can even drop when you’re young, especially if you’ve had a brain injury or developed a chronic health issue. 

Luckily, there are many different ways to optimize and increase IGF-1 levels. 

Researchers have found that IGF-1 levels can be manipulated to improve quality of life and delay the deteriorating effects of brain aging

It doesn’t matter if you’re old, run down, or chronically ill... 

The 27 strategies in this article can naturally boost IGF-1 production and amplify your cognitive performance.  

I’ve divided this article into four main sections:

  • The benefits of IGF-1

  • Food and nutrients that increase IGF-1

  • Supplements and herbs that increase IGF-1

  • Lifestyle habits and therapies that increase IGF-1

Continue reading to learn more and discover how to increase IGF-1.  

Image of brain cell connections.

The Benefits of Increasing Insulin-Like Growth Factor (IGF-1) and How It Affects Your Brain 

IGF-1 is a very important blood marker to monitor. 

Yet many doctors don’t check it. 

This is a shame because it plays a crucial role in healing and brain health.  

Research suggests that IGF-1 levels tend to be low in people struggling with chronic illness and systemic inflammation (87-88, 103).  

Studies also show that IGF-1 crosses the blood–brain barrier and affects the brain and cognitive function (113, 116, 129-131).  

Alzheimer’s disease and dementia are associated with lower IGF-1 levels, and increasing IGF-1 can help prevent the accumulation of amyloid plaque in the brain (104-108).  

Other neurodegenerative diseases, such as Amyotrophic Lateral Sclerosis (ALS) and Parkinson’s disease, are also associated with lower IGF-1 levels, and increasing IGF-1 can help lower your risk of developing these diseases (109-112).  

Researchers have also found that IGF-1 and higher levels of IGF-1 can lead to the following cognitive and neurological health benefits: 

But it doesn’t stop there... 

Many people who have had brain injuries also end up having low levels of IGF-1. 

This is because your brain signals to your liver to produce IGF-1. And when your brain gets injured, it can stop doing this efficiently (122-126).  

Research clearly shows that IGF-1 levels often drop after traumatic brain injuries (TBI), which worsens cognitive dysfunction. This even happens in people who have had mild TBIs. But strategies to increase IGF-1 can increase brain cell survival, repair the brain, and improve cognition after TBIs (117-121).  

I personally had low IGF-1 levels after multiple head injuries.  

But I had no idea for the longest time.  

I eventually found a doctor who actually listened to me, we checked my levels, and I found out they were low.  

I then implemented many of the strategies below to increase and normalize my IGF-1 levels, and I felt better.

It’s important to test and monitor your IGF-1 levels like I did because you don’t want your IGF-1 levels getting too high either. 

 

The Best Foods and Nutrients to Increase Insulin-Like Growth Factor 1 (IGF-1) Naturally

1. Zinc

Zinc is an essential mineral for brain health. 

Unfortunately, it’s estimated that 2 billion people in the world are deficient in zinc, and several studies show that even subclinical zinc deficiency impairs brain function (5-7).  

That’s a problem because a zinc deficiency decreases IGF-1 levels in humans (8).  

In one animal study, feeding a zinc-depleted diet to rats for 14 days resulted in a 28% decrease in IGF-1 compared with rats fed a zinc-adequate diet (9).  

Luckily, zinc supplementation can help.  

Researchers have found that supplementing with zinc significantly increases circulating IGF-1 levels, and increases the synthesis and action of IGF-1 in the body (10-13).  

I created the Optimal Zinc supplement so that you can make sure your zinc and IGF-1 levels are optimal. I created it because I want to give my readers the very best zinc supplement so that they can experience superior results. I have found that many zinc supplements on the market fall short.  Optimal Zinc includes several other nutrients (co-factors) that increase the absorption of zinc. 

Besides supplementing, you should also eat plenty of healthy, whole foods that contain zinc.  

Some of the best foods to optimize your zinc levels include:  

  • Oysters 

  • Grass-fed beef  

  • Pumpkin seeds  

  • Cashews  

  • Mushrooms  

  • Spinach 

These foods are included in my Free Grocery Shopping Guide for Optimal Brain and Mental Health.  

Check out my previous post all about zinc for more steps you can take to increase your zinc levels. 

 

2. Protein

Eating enough high-quality protein is critical if you want to increase your IGF-1 levels.  

Research shows that low protein intake is associated with a major reduction in IGF-1 (69).  

Meanwhile, high-protein diets can increase IGF-1 levels (66-67, 71-72).  

Animal protein and red meat in particular has been shown to increase IGF-1 concentrations (68, 70).  

It's important to keep in mind that muscle meat (chicken breasts, lean beef) shouldn’t be your only source of animal protein.

Our ancestors didn’t eat this way, so neither should we.  

Your body prefers and expects to receive a balance of amino acids from different parts of whole animals. 

That’s why I recommend “head-to-tail eating” – consuming a wide variety of proteins from the entire animal.  

Along with muscle meat, you should regularly cook and eat organ meats such as liver and bone broth. 

I personally don’t like the taste of liver and bone broth can be inconvenient to make all the time, so I often supplement with grass-fed beef liver capsules and drink high-quality pre-made bone broth. 

But if you’re actually interested in learning about how to cook and incorporate more whole animal proteins into your diet, I recommend checking out the book Odd Bits: How to Cook the Rest of the Animal by Jennifer McLagan. 

 

3. Vitamin C

Taking extra Vitamin C is another way to increase IGF-1.  

As you probably know, Vitamin C is found in fruits and vegetables such as green peppers, citrus fruits, tomatoes, cauliflower, Brussels sprouts, broccoli, and cabbage.  

Researchers have found that higher dietary intake of citrus fruits and Vitamin C is associated with higher concentrations of IGF-1 (1).  

In addition to getting Vitamin C from fruits and vegetables, you should take least 500 mg of supplemental Vitamin C every day, just to ensure that you are getting enough. 

Many years ago, I took up to 10 grams of Vitamin C daily, and it definitely improved my mood and reduced stress and anxiety at the time.

Vitamin C is included in this supplement.

Click here to subscribe

4. Blueberries

Eating lots of fruits and vegetables is a great idea if you want to improve your brain health and cognitive function.  

And blueberries are particularly potent because of the flavonoids within them. 

Researchers have found that blueberries improve memory by increasing IGF-1 (2).  

Besides that, blueberries also improve brain health by increasing BDNF and improving brain blood flow

I buy wild blueberries every time I go grocery shopping.  

They are included in my Free Grocery Shopping Guide for Optimal Brain Health.  

Alternatively, you can take a blueberry extract. I used to take one. It’s actually cheaper in the long run than eating blueberries every day, but I just prefer eating actual blueberries.  

In fact, most researchers often use concentrated blueberry extracts instead of actual blueberries when they study the beneficial health effects of blueberries. 

 

5. Magnesium

Magnesium. Magnesium increases IGF-1 levels. Most people are deficient nowadays.

Magnesium is a vital mineral that participates in more than 300 biochemical reactions in your body.  

Unfortunately, a lot of people are deficient in magnesium.  

This is a shame because magnesium is absolutely essential for optimal brain function. 

Research shows that magnesium levels are strongly and independently associated with total IGF-1 levels (14).  

And researchers believe that magnesium deficiency worsens the age-related decline in IGF-1 levels (15).  

Since most people are deficient, magnesium is one of the three supplements that I think everyone should be taking every day.  

Epsom salt baths are another great way to increase your body’s intake of magnesium.  

You should also make sure you’re eating enough magnesium-rich foods on a regular basis, including:  

  • Spinach  

  • Chard  

  • Pumpkin seeds  

  • Almonds  

  • Avocado  

  • Dark chocolate  

  • Bananas  

These foods are included in my Free Grocery Shopping Guide for Optimal Mental Health

Magnesium also supports the blood-brain barrier, increases BDNF, and helps with the formation of new brain synapses

Magnesium is included in this supplement.

 

6. Selenium

Selenium is an essential trace mineral that is important for many bodily processes that affect your brain and mental health. 

Studies show that there is a significant association between selenium and IGF-1 levels (16).  

Animal research has found that a selenium deficiency is linked to lower IGF-1 levels (17).  

And supplementing with selenium has been shown to significantly increase IGF-1 in elderly individuals (18-19).  

Selenium is included in this supplement.

Brazil nuts are the richest dietary source of selenium, but it can also be found in wild-caught seafood, pastured chicken and eggs, and grass-fed meat.  These foods are included in my Free Grocery Shopping Guide for Optimal Brain and Mental Health.

Click here to subscribe

7. Cinnamon

Cinnamon is a tasty spice that has a number of health benefits.  

It has anti-inflammatory effects, it’s loaded with antioxidants, and it's even been shown to have beneficial effects on neurodegenerative diseases, including Alzheimer's disease and Parkinson’s disease (46-49).  

Researchers have also found that cinnamon extract significantly activates IGF-1 signaling (50-51).  

Not all cinnamon is created equal though. 

You’ll have to find and consume Ceylon, which is considered “true cinnamon”. It has the most health benefits.  

Most cinnamon in grocery stores is cheap and not actually Ceylon. 

You can usually find Ceylon in health food stores.  

 

8. Vitamin D

Vitamin D capsules in a clear bowl. Vitamin D supplements can increase IGF-1 levels, especially if you’re deficient.

Vitamin D is a fat-soluble vitamin that your skin synthesizes when exposed to the sun.  

Unfortunately, researchers estimate that 50% of people are at risk of Vitamin D deficiency.  

This is a huge problem because every tissue in your body has Vitamin D receptors, including the brain, so a deficiency can lead to costly physiological and psychological consequences. 

Research shows that Vitamin D significantly increases circulating IGF-1 levels in adults (25).  

Ideally, you should get your Vitamin D by going outside and getting sun.  

I try to get sunlight every day during the spring and summer months.  

But most people still don’t get enough Vitamin D from the sun, especially during the winter.  

During the winter months, when there isn't enough sun, I’ll take a Vitamin D3 supplement.

It's important to test and monitor your Vitamin D levels before and after supplementing with it.

 

9. Thiamine

Thiamine, also known as Vitamin B1, is an essential water-soluble nutrient that cannot be made by the body.  

It’s used in nearly every cell in the body and especially important for supporting energy levels. 

Researchers have found that Vitamin B1 plays a key role in the IGF-1 system, and a deficiency leads to a significant drop in IGF-1 levels (27).  

Vitamin B1 is included in Optimal Energy.

Healthy food sources of Vitamin B1 include green peas, beef liver, asparagus, pecans, spinach, sunflower seeds, macadamia nuts, oranges, cantaloupe and eggs.  

These foods are included in my Free Grocery Shopping Guide for Optimal Brain Health

 

10. Dried Plum

Plums are an extremely nutritious food, containing many vitamins and minerals, as well as antioxidants and fiber.

They can help reduce your risk of several chronic diseases.

Dried plums, or prunes, can also be eaten to increase IGF-levels.

One study found that consumption of dried plums daily by postmenopausal women significantly increased their IGF-1 levels by 17% (132).

 

The Best Supplements and Herbs to Increase Insulin-Like Growth Factor 1 (IGF-1) Naturally 

11. Probiotics

The beneficial bacteria in your gut are known to convert the food you eat into short-chain fatty acids.  

These probiotic bacteria - and the short-chain fatty acids that they produce - play a critical role in the synthesis of IGF-1 in your body and brain.  

Research clearly shows that the following probiotics stimulate the IGF-1 system and increase IGF-1 concentrations (33-40).  

All four of these probiotics are included in the Optimal Biotics supplement

Meanwhile, antibiotics have been shown to decrease IGF-1 (41).  

Check out this article for several other ways to increase your good gut bacteria.  

And if you struggle with anxiety, here are 9 probiotic strains that can help. 

 

12. Dehydroepiandrosterone

Dehydroepiandrosterone (DHEA) is one of the most abundant circulating steroid hormones in humans. It’s produced in the adrenal glands, the gonads, and the brain, and it’s a precursor to other hormones, including estrogen and testosterone.  

It's also available as a supplement. 

DHEA has been shown to have neuroprotective effects, and it’s also known to improve memory and cognition. 

In one study, a 100 mg daily dose of DHEA for six months elevated IGF-1 levels in both men and women (3).  

It's also one of the best supplements for reducing depression

 

13. Taurine

Taurine is an organic compound found in food, particularly meat and seafood.  

Taken as a supplement, it can improve your mood and reduce your anxiety because it can cross the blood-brain barrier and increase oxytocin, dopamine and BDNF in the brain. 

It turns out that it can also increase IGF-1 levels and increase the synthesis of IGF-1 (42-43). 

 

14. Resveratrol

Resveratrol is a beneficial antioxidant and anti-inflammatory compound found in grapes, red wine, raspberries and dark chocolate.  

It’s known to help prevent the development of neurodegenerative diseases.  

And researchers are starting to understand why. 

In one study, resveratrol was shown to improve cognitive function by increasing the production of IGF-1 in the brain (4).  

It’s also been shown to increase BDNF, synaptogenesis, autophagy and blood flow in the brain. 

To consume enough resveratrol to increase IGF-1, you’ll need to supplement with it.  

Resveratrol is included in this supplement.

Click here to subscribe

15. Leucine

Leucine is one of three branched chain amino acids (BCAA).  

It's an essential amino acid, meaning you’ll need to get it from food or supplements.  

Athletes and bodybuilders often take it as a supplement because it helps increase energy, improve strength and build muscle.  

Researchers have found that leucine significantly increases IGF-1 and IGF binding protein (52).  

You can get leucine from protein-rich foods, such as fish, chicken and turkey.  These foods are included in my Free Grocery Shopping Guide for Optimal Brain Health

But you may want to supplement with it if your goal is to increase IGF-1.  

I include leucine in this supplement because it prevents mercury from being reabsorbed into the central nervous system.

 

16. Astragalus

Illustration of the astragalus plant. Astragalus can increase IGF-1 levels.

Astragalus is an adaptogenic herb that has been used for centuries by traditional Chinese medicine practitioners to support the immune system and reduce inflammation.  

There are more than 2,000 species of Astragalus, but usually Astragalus supplements simply contain Astragalus membranaceus.  

Astragalus membranaceus extract has been shown to significantly increase IGF-1 levels in humans and animals (53-57).  

It's available in many forms, including liquid extracts, capsules, powders and teas. 

 

17. Colostrum

Colostrum is a special kind of milk, also known as “first milk”. 

It’s naturally produced by the mammary glands of mammals immediately following the delivery of a newborn. 

It contains a number of different nutrients and growth factors, including IGF-1, that support the health and development of a newborn baby (58). 

Colostrum from cows (bovine colostrum) can be taken as a supplement by humans for its health benefits.  

Research shows that colostrum supplementation significantly increases circulating levels of IGF-1 (59-60).  

 

18. Acetyl-L-Carnitine

Acetyl-L-carnitine (ALCAR) is an acetylated form of the amino acid carnitine.  

It’s been shown to have neuroprotective and cognitive-enhancing effects. It’s often used as a natural brain booster because it increases alertness and provides support to brain cells.  

ALCAR has also been shown to be very effective at alleviating chronic fatigue and improving mood. It helps reverse neurological decline and supports mitochondria function as well. 

It does so much, so not surprisingly, researchers have also found that ALCAR increases IGF-1 levels in humans (20).  

Animal studies also show that it increases IGF-1 levels in rats (21-22).  

When I first took it years ago, ALCAR gave me a big boost in mental energy and cognitive function.  

That’s why it’s included in the Optimal Brain supplement

Make sure you read this article to learn more about the remarkable benefits of ALCAR.

Click here to subscribe

19. Creatine

Creatine is a molecule produced in the body and found in some foods, particularly meat, eggs, and fish.  

Creatine is also available as a supplement. Athletes, bodybuilders, wrestlers, sprinters often take extra creatine to gain more muscle mass. It’s an incredibly well-researched supplement and safe to take regularly. 

Supplementing with creatine can also support the brain. It's been shown to have neuroprotective effects and it rapidly produces energy to support brain cell function (23).  

In one study, healthy individuals took creatine every day for 5 days, and researchers witnessed a 30 per cent increase in IGF expression (24).  

 

20. Ursolic Acid

An apple partially peeled. Apple peels contain ursolic acid, a natural compound that can increase IGF-1 levels.

Ursolic Acid is a natural compound found in a variety of plants and herbs, such as apple peels, rosemary, thyme and holy basil. Apple peels contain the largest amount. 

In one study, supplementing with 100 mg of Ursolic Acid, three times daily, increased IGF-1 levels in humans by 22.8 per cent (62).  

Animal research also shows that it increases IGF-1 signaling and enhances IGF-1 receptors (61, 63).  

You can get pure Ursolic Acid.

Or you can supplement with the herb Holy Basil, which contains some Ursolic Acid. But it may not be as effective as taking pure Ursolic Acid.  

 

21. Hydroxy Methyl Butyrate

Hydroxy Methyl Butyrate (HMB) is a metabolite of leucine. 

It's also a dietary supplement used by athletes and bodybuilders to increase muscle strength and development. 

Studies show that HMB supplementation increases the expression and levels of IGF-1 (64-65).  

 

22. Coenzyme Q10

Coenzyme Q10 (CoQ10) is a coenzyme and antioxidant located primarily in the mitochondria. It has numerous known health benefits and plays a critical role in producing energy for the body.  

CoQ10 is produced within the body, but it’s also found within food and can be supplied to the body through food or supplementation. It resembles a fat-soluble vitamin. 

Meat and fish are the richest sources of dietary CoQ10, including beef, pork, chicken heart, and chicken liver. Nuts and some oils also contain some CoQ10.  These foods are included in my Free Grocery Shopping Guide for Optimal Brain Health

Research shows that supplementing with CoQ10 significantly increases IGF-1 levels (26).  

CoQ10 is included in Optimal Energy.

 

The Best Lifestyle Habits, Therapies and Practices to Increase Insulin-Like Growth Factor 1 (IGF-1) Naturally

23. Low-Level Laser Therapy

Low-level laser therapy (LLLT), or photobiomodulation, is a treatment that uses low-level (low-power) lasers or light-emitting diodes (LEDs) to stimulate brain cells, helping them function better.  

Dr. Norman Doidge, a psychiatrist and researcher who teaches at the University of Toronto, discusses the amazing effects of LLLT in his book The Brain’s Way of Healing

Several studies show that LLLT increases the expression, production and release of IGF-1 (28-32).  

I previously wrote about my experience with low-level laser therapy here.  

You can use this device and shine the red and infrared light on your forehead for 5 minutes every day. You can also shine it on other parts of your head and on your entire body, including on your thyroid, thymus gland and gut. I have experienced incredible benefits from doing this.

You can also use this smaller and more convenient device and shine it on your forehead.

I’ve also used the Vielight Neuro Duo, which is a transcranial-intranasal headset with 810 nm of near infrared light. It penetrates deeper into brain tissue and is absorbed better by the central nervous system. If you decide to try a Vielight device, you can use the coupon code JORDANFALLIS for a 10% discount

Before trying LLLT, I highly recommend reading my full article about it first.

 

24. Exercise

A cartoon woman lifting weights over her head. Exercise powerfully increases IGF-1 levels.

Exercise is probably the best way to boost IGF-1 levels, as it also appears to “push” IGF-1 to the brain to improve its function.  

There are two main forms of exercise that you need to engage in if you want to increase your IGF-1 levels – high-intensity interval training (HIIT) and resistance training.  

Research shows that resistance training (also known as strength training or weight training) significantly increases IGF-1 and increases the bioavailability of IGF-1 (73).  

Intense and strenuous HIIT workouts cause a significant increase in circulating levels of IGF-1 (74).  

Besides increasing IGF-1, exercise can also induce autophagy in the brain, increase dopamine and BDNF, and increase blood flow to the brain

That’s why many doctors and researchers recommend exercise as their number one piece of advice for optimal brain health.  

 

25. Deep Sleep

Getting enough high-quality, deep sleep is very important if you want to increase your IGF-1 levels and improve your brain and mental health. 

I used to have very poor sleep and it was one of the main factors that contributed to my low IGF-1 levels and poor cognitive function. 

Sleep deprivation is known to suppress IGF-1 in humans and animals (75, 78-79).  

Meanwhile, sleep extension significantly increases IGF-I concentrations (76).  

In one study, researchers found that increased deep sleep is associated with higher levels of IGF-1 in healthy older men (77).  

And in another study, improving the sleep quality of military personnel led to a significant increase in their IGF-1 levels, and a significant reduction in their symptoms of depression and PTSD (80).  

So, it’s not just the length of your sleep that matters. 

It’s also the depth and quality of your sleep.  

If you’re having trouble with sleep, try this sleep supplement. It contains natural compounds that I’ve used over the years to promote deeper and more restful sleep.  

I also work with my clients so that they can naturally produce more melatonin and maximize the quality of their sleep without so many supplements. We have free online workshop that talks about how you can work with us. You can register for the workshop here.

Click here to subscribe

26. Reduce Inflammation

Reducing inflammation throughout your entire body is a key step towards increasing your IGF-1 levels naturally. 

Research clearly shows that proinflammatory cytokines inhibit and impair IGF-1 bioactivity, and induce a state of IGF resistance (81-85).  

There are many causes of chronic inflammation, including infections, mold, brain injuries, and leaky brain.  

But one of the most common causes – and the one you have the most control over – is your diet.  

That’s why it’s a good idea to follow an anti-inflammatory diet and avoid foods such as gluten and dairy that can trigger inflammation in the gut and brain. You shouldn’t have to follow a restrictive diet like this forever. But it can still be helpful as a short-term approach.

You can also remove processed food from your diet, and increase your intake of vegetables, fruits, wild fish, grass-fed beef and organic chicken.  

Check out my Free Grocery Shopping Guide for Optimal Brain and Mental Health for a full list of anti-inflammatory foods.  

Other steps you can take to reduce inflammation include reducing stress, exercising, improving gut health, treating infections and getting enough sleep. 

Make sure you also check out this article for 23 effective ways to reduce inflammation in the brain.

 

27. Avoid or Limit Alcohol

A glass of alcohol. Alcohol should be avoided if you want to increase your IGF-1 levels.

Alcohol is a neurotoxin that wreaks havoc on the brain by raising cortisol levels, disrupting the blood-brain barrier, and increasing inflammation and oxidative stress. 

It also lowers your IGF-1 levels. 

Researchers have found that high alcohol intake inhibits IGF-1 (86).  

There are ways to protect your brain from alcohol, but you’re better off avoiding it completely or significantly reducing your consumption if you’re trying to heal. I personally don’t drink alcohol at all anymore.  

If you do decide to drink it, this post explains that some types of alcohol are better than others. 

 

28. Sauna Sessions

When it comes to improving your health, some of the simplest strategies can have a huge impact.  

Using a sauna regularly is one of them. 

Research suggests that daily sauna sessions can significantly increase the production of growth hormone and IGF-1 (44-45).  

Once you start using a sauna, you should listen to your body to determine how much time you should spend in it. Start out slowly and increase the length of your sessions over time.  

Also, make sure to drink lots of water before and after each session, and never consume alcohol in combination.  

Check out this post to learn more about saunas and the 13 ways they can improve your brain and mental health.  

 

Enjoy This Article? You Might Also Like My FREE Food Guide for Optimal Brain and Mental Health!

Click here to subscribe

Live Optimally,

Jordan Fallis

Connect with me

References:

(1) http://ajcn.nutrition.org/content/84/6/1518.full 

(2) https://www.tandfonline.com/doi/abs/10.1080/10284150400020482 

(3) https://www.ncbi.nlm.nih.gov/pubmed/9876338 

(4) https://www.ncbi.nlm.nih.gov/pubmed/21295960  

(5) http://www.ncbi.nlm.nih.gov/pubmed/22664333  

(6) http://www.ncbi.nlm.nih.gov/pubmed/21939673  

(7) http://www.ncbi.nlm.nih.gov/pubmed/22673824 

(8) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820068/ 

(9) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820068/ 

(10) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820068/ 

(11) https://www.ncbi.nlm.nih.gov/pubmed/11712076 

(12) https://www.ncbi.nlm.nih.gov/pubmed/8532589 

(13) https://www.ncbi.nlm.nih.gov/pubmed/7845370 

(14) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820068  

(15) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820068 

(16) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820068  

(17) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820068 

(180 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469470/  

(19) https://www.ncbi.nlm.nih.gov/pubmed/20416996 

(20) https://www.ncbi.nlm.nih.gov/pubmed/10413658  

(21) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631133/ 

(22) https://www.ncbi.nlm.nih.gov/pubmed/23497226  

(23) https://examine.com/supplements/creatine/ 

(24) https://ast-ss.com/boost-igf-1-levels-by-30-new-research-shows-you-how/  

(25) https://eje.bioscientifica.com/view/journals/eje/169/6/767.xml  

(26) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469470/  

(27) https://www.sciencedirect.com/science/article/pii/0955286396000113  

(28) https://www.ncbi.nlm.nih.gov/pubmed/22714676  

(29) http://www.scielo.br/scielo.php?pid=S0365-05962011000500013&script=sci_arttext&tlng=en  

(30) https://www.omicsonline.org/open-access/effects-and-action-mechanism-of-low-level-laser-therapy-lllt-applications-in-periodontology-2161-1122-1000514-104623.html  

(31) https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcb.26265  

(32) https://www.intechopen.com/books/photomedicine-advances-in-clinical-practice/biological-function-of-low-reactive-level-laser-therapy-lllt-  

(33) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127374/  

(34) https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/lactobacillus-acidophilus-modulates-inflammatory-activity-by-regulating-the-tlr4-and-nfb-expression-in-porcine-peripheral-blood-mononuclear-cells-after-lipopolysaccharide-challenge/E12E96E37FEDC02336B7A10ED302628C/core-reader 

(35) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131626/ 

(36) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120984/ 

(37) https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0045572 

(38) https://www.ncbi.nlm.nih.gov/pubmed/27596801  

(39) https://www.researchgate.net/publication/307885332_Supplementation_with_Lactobacillus_rhamnosus_SP1_normalises_skin_expression_of_genes_implicated_in_insulin_signalling_and_improves_adult_acne  

(40) http://www.nrcresearchpress.com/doi/pdf/10.4141/A00-037  

(41) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127374/  

(42) https://www.ncbi.nlm.nih.gov/pubmed/25963419 

(43) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071367/ 

(44) https://www.ncbi.nlm.nih.gov/pubmed/999213 

(45) https://www.ncbi.nlm.nih.gov/pubmed/3788622 

(46) https://www.ncbi.nlm.nih.gov/pubmed/19433898 

(47) https://www.ncbi.nlm.nih.gov/pubmed/23531502 

(48) https://www.ncbi.nlm.nih.gov/pubmed/24349472 

(49) https://www.ncbi.nlm.nih.gov/pubmed/24946862  

(50) https://www.ncbi.nlm.nih.gov/pubmed/22233457 

(51) https://thescipub.com/PDF/ajbbsp.2010.204.212.pdf  

(52) https://www.ncbi.nlm.nih.gov/pubmed/25909895  

(53) https://www.researchgate.net/publication/267390251_Astragalus_Membranaceus_Supplement_Increased_the_Concentration_of_IGF-1_for_Damaging_Muscle_in_Human 

(54) https://www.ncbi.nlm.nih.gov/pubmed/29130588  

(55) https://www.hindawi.com/journals/ecam/2017/6935802/  

(56) https://www.ncbi.nlm.nih.gov/pubmed/28164139  

(57) https://www.ncbi.nlm.nih.gov/pubmed/22388791  

(58) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1148968/  

(59) https://www.ncbi.nlm.nih.gov/pubmed/18443138 

(60) https://www.ncbi.nlm.nih.gov/pubmed/12133885 

(61) https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0039332  

(62) https://www.ncbi.nlm.nih.gov/pubmed/25352765  

(63) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379974/  

(64) https://www.ncbi.nlm.nih.gov/pubmed/21237681  

(65) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537867/  

(66) https://www.ncbi.nlm.nih.gov/pubmed/16900085?dopt=Abstract  

(67) https://pdfs.semanticscholar.org/4148/f158df7d4264f91de7266cd3c0b9696358ed.pdf  

(68) https://pdfs.semanticscholar.org/4148/f158df7d4264f91de7266cd3c0b9696358ed.pdf  

(69) https://www.ncbi.nlm.nih.gov/pubmed/24606898  

(70) http://ascopubs.org/doi/abs/10.1200/jco.1999.17.10.3291  

(71) https://www.ncbi.nlm.nih.gov/pubmed/21590739  

(72) https://www.ncbi.nlm.nih.gov/pubmed/12223429  

(73) https://www.ncbi.nlm.nih.gov/pubmed/10708256  

(74) https://www.ijmrhs.com/medical-research/effects-of-high-intensity-interval-training-on-plasma-levels-of-gh-and-igfi.pdf 

(75) https://www.ncbi.nlm.nih.gov/pubmed/27560704  

(76) https://www.ncbi.nlm.nih.gov/pubmed/27560704  

(77) https://www.ncbi.nlm.nih.gov/pubmed/7614245  

(78) https://www.ncbi.nlm.nih.gov/pubmed/14871886  

(79) https://www.ncbi.nlm.nih.gov/pubmed/25373853  

(80) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442222/  

(81) https://www.ncbi.nlm.nih.gov/pubmed/18325486/  

(82) https://www.ncbi.nlm.nih.gov/pubmed/10422792 

(83) https://www.ncbi.nlm.nih.gov/pubmed/20009360 

(84) https://www.ncbi.nlm.nih.gov/pubmed/8218594/ 

(85) https://www.mdpi.com/2072-6643/5/10/4184 

(86) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448087/  

(87) https://www.ncbi.nlm.nih.gov/pubmed/1909610/ 

(88) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978663/ 

(89) https://www.ncbi.nlm.nih.gov/pubmed/11720784/ 

(90) https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem.84.2.5455 

(91) https://www.ncbi.nlm.nih.gov/pubmed/14568359 

(92) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677055/  

(93) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348499/ 

(94) https://www.ncbi.nlm.nih.gov/pubmed/14598295/ 

(95) https://www.nature.com/mp/journal/v12/n12/full/4002076a.html 

(96) https://www.ncbi.nlm.nih.gov/pubmed/10022403  

(97) https://www.ncbi.nlm.nih.gov/pubmed/10751445  

(98) https://www.ncbi.nlm.nih.gov/pubmed/8418780 

(99) https://www.ncbi.nlm.nih.gov/pubmed/10757380 

(100) https://www.ncbi.nlm.nih.gov/pubmed/26362717 

(101) https://www.ncbi.nlm.nih.gov/pubmed/7533956 

(102) https://www.ncbi.nlm.nih.gov/pubmed/18223378 

(103) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2492581/ 

(104) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013812/ 

(105) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314463/ 

(106) https://www.ncbi.nlm.nih.gov/pubmed/12415260 

(107) https://dx.doi.org/10.1038/nm793 

(108) https://link.springer.com/article/10.1007/s00221-016-4572-1 

(109) https://www.ncbi.nlm.nih.gov/pubmed/12067233 

(110) https://ncbi.nlm.nih.gov/pmc/articles/PMC3211070 

(111) https://dx.doi.org/10.1038/nm793 

(112) https://link.springer.com/article/10.1007/s00221-016-4572-1 

(113) https://www.ncbi.nlm.nih.gov/books/NBK299190/  

(114) https://academic.oup.com/endo/article/149/12/5958/2455262 

(115) https://academic.oup.com/endo/article/149/12/5958/2455262 

(116) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291552/ 

(117) https://www.ncbi.nlm.nih.gov/pubmed/25497343 

(118) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568328/ 

(119) https://www.ncbi.nlm.nih.gov/books/NBK299190/  

(120) https://www.hindawi.com/journals/bmri/2015/736104/ 

(121) https://www.mdpi.com/1422-0067/18/11/2441/htm 

(122) https://www.ncbi.nlm.nih.gov/pubmed/25497343 

(123) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568328/ 

(124) https://www.ncbi.nlm.nih.gov/books/NBK299190/ 

(125) https://www.hindawi.com/journals/bmri/2015/736104/ 

(126) https://www.mdpi.com/1422-0067/18/11/2441/htm 

(127) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5285390/  

(128) https://www.ncbi.nlm.nih.gov/pubmed/27038749 

(129) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568328/ 

(130) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5285390/ 

(131) https://pdfs.semanticscholar.org/7ead/c0efe7ff3f325ef81e63d992d09d51d5bfee.pdf 

(132) https://www.ncbi.nlm.nih.gov/pubmed/19274852

Terms and Conditions

Privacy Policy

Affiliate Disclosure

Disclaimer

The 9 Most Promising Psychobiotics for Anxiety

I used to walk around ruminating, struggling with inner turmoil and nervousness all the time. 

It never went away.

It was impossible to shake. 

It wore me down and ruined the quality of my life. 

There’s no doubt that fear and vigilance are helpful when you’re faced with an actual threat. 

But an unnecessarily high state of worry and arousal when there is nothing threatening you? That's a nightmare. 

It doesn’t have to be that way though. 

If you have chronic anxiety, there are ways to manage and reverse it, like I have.

And psychobiotics are one way to do that.

Psychobiotics are probiotics and prebiotics that can improve your mental health by changing the mixture of bacteria in your gut (46-47). 

It is estimated that 100 trillion bacteria, and 500 to 1,000 species of bacteria, live in the human gut. These gut bacteria, collectively known as the gut microbiome, help with digestion. But an increasing amount of research suggests that they also communicate with your brain through the microbiome-gut-brain axis, affecting your thoughts, feelings and behaviour (48-49). 

Gut is playing chess with Brain. Gut says “Gutsy move for a brain…”.

A dysfunctional gut microbiome has been linked to a number of mental health problems and psychiatric conditions, including anxiety.

In fact, anxiety and gut health are very tightly linked. 

Research shows that people who have digestive disorders are more likely to have anxiety, and those with anxiety have higher rates of gastrointestinal disease (50-52).

And studies show that when digestive disorders improve, anxiety improves as well (53). 

Unfortunately, a lot of people have poor gut health today because of the widespread use of antibiotics, medications, herbicides, stress, infections, poor diet, etc. 

But don’t worry. You can improve your gut health and anxiety at the same time with the use of psychobiotics. 

Studies show that psychobiotics can improve anxiety by (54-55):

Here are the nine best psychobiotics that have been shown in human and animal studies to decrease stress and help treat anxiety disorders. 

They are truly the best probiotics for anxiety.

The word psychobiotic.

1. Lactobacillus rhamnosus

Lactobacillus rhamnosus is a bacterium found in the human gut. It is one of the most popular probiotic species found in supplements.

Preliminary research suggests that supplementing with lactobacillus rhamnosus can lower anxiety in humans (3). 

GABA is the main inhibitory and relaxing neurotransmitter in the central nervous system, and studies suggest that lactobacillus rhamnosus may reduce anxiety by changing the expression of GABA receptors (1-2, 4). 

In one study, researchers gave lactobacillus rhamnosus to mice, and it reduced their anxiety-like behaviours. But when researchers removed part of their vagus nerve, lactobacillus rhamnosus did not reduce their anxiety, suggesting that psychobiotics communicate with the brain and improve mental health through the vagus nerve (1-2). 

The mice [given lactobacillus rhamnosus] were more chilled out.
— Dr. John Cryan, researcher and pharmacologist with the Alimentary Pharmabiotic Center at University College Cork, Ireland

Other studies have found that lactobacillus rhamnosus decreases stress-induced anxiety-like behaviour, and researchers have concluded that it can protect against anxiety (5, 7). 

Lactobacillus rhamnosus has also been shown to reduce obsessive-compulsive disorder (OCD)-like behaviour in mice. In fact, researchers found it was just as effective as fluoxetine, an SSRI antidepressant commonly used to treat OCD (6). 

So if you struggle with OCD or obsessive-compulsive tendencies, it’s worth trying this psychobiotic.

Lactobacillus rhamnosus can be found in some yogurt and dairy products, such as fermented and unpasteurized milk and semi-hard cheese. But I typically don’t recommend eating these foods until you are healthy enough to tolerate them.

 

2. Bifidobacterium longum

Bifidobacterium longum is another bacterium present in the human gut. It is often added to food as it can help prevent the growth of pathogenic organisms.

I previously wrote about how it’s been proven to help treat depression.

Bacteria. Bacteria can affect the mind through the gut-brain axis.

But it can also reduce anxiety. 

Researchers have concluded that bifidobacterium longum can reduce cortisol and alleviate psychological distress in humans (including obsessions, compulsions, paranoia, anxiety) (28-30). 

Lots of animal research also shows that bifidobacterium longum can significantly reduce anxiety-like behaviour (31-34). 

One study found that a chronic infection in mice increased inflammation and caused anxiety-like behaviour, but bifidobacterium longum reduced anxiety and normalized behaviour (35-36). 

Researchers have even figured out that it works by acting through the vagus nerve (27). 

Click here to subscribe

3. Lactobacillus plantarum

Lactobacillus plantarum is another probiotic species that can reduce anxiety. 

In one study, researchers gave lactobacillus plantarum to patients with irritable bowel syndrome and it significantly reduced their anxiety and improved their quality of life (8). 

Animal studies also show that lactobacillus plantarum can cause positive changes in emotional behaviours and significantly reduce anxiety-like behaviours. It does this by increasing dopamine and serotonin, lowering stress hormone levels, and reducing inflammation (9-11). 

As a result, researchers have concluded that lactobacillus plantarum has psychotropic properties without physical side effects, and has great potential for treating neuropsychiatric disorders, including anxiety (9-11). 

Lactobacillus plantarum is also commonly found in many fermented vegetables including sauerkraut, pickles, brined olives, kimchi.

 

4. Lactobacillus helveticus

Lactobacillus helveticus is a probiotic that has been shown to reduce cortisol and have anti-anxiety effects in humans (37, 39, 44).

One study found that it can even reduce paranoid and obsessive-compulsive thoughts (38). 

Blue bacteria. Bacteria can influence our anxiety levels.

Animal research shows that a Western-style diet can negatively change the gut microbiome, increase brain inflammation, and contribute to anxiety. But lactobacillus helveticus can protect against this, reducing both neuroinflammation and anxiety (40-42).

One study even found that lactobacillus helveticus works better than citalopram, a common SSRI antidepressant, at reducing anxiety-like behaviour in rats. It also reduced their stress hormone levels and increased their serotonin levels (43). 

Lactobacillus helveticus is also commonly found in American Swiss cheese and Emmental cheese, and sometimes other cheeses, such as Cheddar, Parmesan, Romano, provolone, and mozzarella.

If you’re healthy enough to tolerate cheese, you could try adding some of these cheeses into your diet. 

Click here to subscribe

5. Lactobacillus reuteri

Lactobacillus reuteri is a bacterium with anti-inflammatory effects that scientists first discovered in the 1980s. 

It is usually found in the human gut. However, not all humans have it, and some people simply have very low levels of it. Therefore, you may need to supplement with it to introduce and maintain high levels of it.

Research shows that Lactobacillus reuteri can reduce anxiety-like behaviours in animals by reducing stress hormone levels and altering the expression of GABA receptors (13-14).

And one study found that the absence of lactobacillus reuteri causes social deficits in animals.

We found that treatment with this single bacterial strain was able to rescue their social behavior.
— Shelly Buffington, neuroscience researcher at Baylor College of Medicine

By adding it back in to the guts of the animals, the researchers were able to reverse some of their behavioural deficits, which were similar to symptoms of social anxiety and autism in humans (15-16). 

Therefore, lactobacillus reuteri is definitely the psychobiotic worth trying if you struggle with social anxiety or symptoms of autism.

It's also found in breast milk, and some meat and dairy products.

 

6. Lactobacillus casei

Lactobacillus casei is another bacterium found in the human gut. It has antioxidant and anti-inflammatory effects.

In one double-blind, placebo-controlled trial, patients with chronic fatigue syndrome and digestive problems took Lactobacillus casei as a daily supplement for two months. At the end of the study, they had a significant decrease in their anxiety symptoms (17-19). 

So this is a good psychobiotic to try if you struggle with a mixture of fatigue, digestive problems and anxiety.

Lactobacillus casei is the dominant species in naturally fermented Sicilian green olives, and can also be found in other fermented vegetables and dairy products. 

 

7. Lactobacillus fermentum

Lactobacillus fermentum is another species that is part of the human microbiome and commonly found in fermented vegetables.

It hasn’t been studied as much as other lactobacillus probiotic species.

Bacteria. Psychobiotics are bacteria that affect our psychological state of mind.

But there still is some evidence that is may be able to help treat anxiety, especially if you have a long history of antibiotic treatment. 

Research shows that antibiotics can trigger anxiety in animals by disturbing the microbiome.

But by giving animals lactobacillus fermentum, researchers can reduce the inflammation and reverse the psychological problems brought on by antibiotics, including anxiety-like behaviour (12).

So if you’ve taken a lot of antibiotics over the years, or noticed that your anxiety got worse after taking a course of antibiotics, taking a psychobiotic supplement with lactobacillus fermentum is worth a try. 

Click here to subscribe

8. Bifidobacterium breve

Bifidobacterium breve is a beneficial bacterium found in human breast milk and the human gut. The amount in your gut declines as you get older (20). 

Research shows that bifidobacterium breve can reduce anxiety-like behaviour in animals (21). 

Anxious animals also perform better on cognitive tests after being given it (22). 

This makes bifidobacterium breve a great psychobiotic option if your anxiety impairs your cognition and interferes with your ability to complete tasks. 

Bifidobacterium breve can be found naturally in some fermented foods.

 

9. Galacto-oligosaccharides

Not all psychobiotics are simply probiotics.

Psychobiotics can also include “prebiotics,” which are non-digestible soluble fibres that stimulate the growth of good gut bacteria, and therefore improve mental health and reduce anxiety.

Galacto-oligosaccharides (GOS) are a type of prebiotic that have been shown to do just that. 

Picture of intestines. Our intestinal health can significantly affect our mental health.

In one study, GOS significantly decreased the secretion of cortisol, and participants paid more attention to positive information rather than negative information (23).

People who are anxious tend to have high levels of cortisol and often get caught up in negative thinking. So this study suggests that GOS has anti-anxiety effects. 

Other research has demonstrated that people with irritable bowel syndrome (IBS) often have anxiety because of the lack of microbial diversity in their gut. However, when IBS sufferers supplement with a prebiotic mixture containing GOS, it significantly reduces their anxiety and improves the quality of their life (24-26). 

 

What Psychobiotic Should You Take?

Ideally, you should buy and try one psychobiotic at a time to figure out how you respond to each one.

That's what I did over the span of several years. 

I would buy and try one probiotic, take it for at least one month, and then monitor how I felt during that time.

Sometimes I would stop taking it if I felt worse.

I was my own guinea pig and tested and experimented with so many different probiotic supplements to find the ones that helped. 

I usually recommend people follow the same process because many people like myself often experience a bad reaction to one, but a good reaction to another. 

But I understand doing that can be time-consuming and tedious. Plus, clinical studies often demonstrate that probiotic mixtures with multiple bacteria are better at improving the diversity of gut bacteria than individual ones (45). 

So, to make it easier for you, I’ve now created my own psychobiotic supplement, called Optimal Biotics.

I created it because I want to give my readers the very best psychobiotic supplement so that they can experience superior results.

I have found that many psychobiotic supplements on the market fall short and even cause side effects.

But Optimal Biotics doesn't, and it contains the 8 most well-researched and beneficial probiotic strains for your mental health.

I also recommend adding fermented foods into your diet and see how that goes. Fermented foods contain many strains of bacteria that have not been documented in the scientific literature.  That said, the downside is that the bacteria in fermented foods will vary depending on the batch, and there is sometimes the risk of them containing pathogenic bacteria.

Here are some other steps you can take to increase the good bacteria in your gut. 

And this anti-anxiety supplement also includes several other natural compounds that have helped me manage my anxiety over the years. It can help reduce stress and anxiety while you work to improve your gut health.

 

Conclusion

The microbiome and psychobiotics are at the cutting-edge of neuroscience and mental health research and treatment. It hasn’t been that long since researchers first discovered that there is a gut-brain connection. 

Cartoon image of bacteria and psychobiotics.

When I first found out about it several years ago, I started consuming psychobiotics, and they have definitely helped me chronic anxiety over the years. 

But it’s important to point out that psychobiotics alone were never enough.

I also had to make changes to my diet, take key supplements, improve thyroid health, and overcome trauma. There really is no quick fix or magic bullet. 

Yet for some people, psychobiotics can be life changing, especially if you have digestive issues alongside your anxiety and worry. 

Overall, I think they are absolutely worth a try. 

I hope this article helps you, and please share it with anyone you think might benefit from it. 

 

Enjoy This Article? You Might Also Like My FREE Food Guide for Optimal Brain and Mental Health!

Click here to subscribe

Live Optimally,

Jordan Fallis

Connect with me

References:

(1) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370913/

(2) https://www.ncbi.nlm.nih.gov/pubmed/21876150/

(3) https://www.ncbi.nlm.nih.gov/pubmed/25879690

(4) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934620/

(5) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225647/

(6) http://www.ncbi.nlm.nih.gov/pubmed/24257436

(7) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200314/

(8) https://www.ncbi.nlm.nih.gov/pubmed/25024629

(9) http://www.ncbi.nlm.nih.gov/pubmed/26620542

(10) http://www.ncbi.nlm.nih.gov/pubmed/26522841

(11) https://www.sciencedaily.com/releases/2016/11/161121160038.htm

(12) http://www.ncbi.nlm.nih.gov/pubmed/25869281

(13) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754198/

(14) http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2982.2010.01664.x/full#b28

(15) https://www.sciencedaily.com/releases/2016/06/160616140723.htm

(16) http://www.cell.com/cell/fulltext/S0092-8674(16)30730-9

(17) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664325/

(18) https://gutpathogens.biomedcentral.com/articles/10.1186/1757-4749-1-6

(19) http://www.ncbi.nlm.nih.gov/pubmed/19338686/

(20) http://journal.frontiersin.org/article/10.3389/fmicb.2016.01204/full

(21) https://www.ncbi.nlm.nih.gov/pubmed/25251188

(22) https://www.ncbi.nlm.nih.gov/pubmed/25794930

(23) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410136/

(24) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370913/

(25) http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2008.03911.x/abstract

(26) http://www.ncbi.nlm.nih.gov/pubmed/19053980

(27) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413724/

(28) https://www.ncbi.nlm.nih.gov/pubmed/20974015/

(29) http://www.tandfonline.com/doi/abs/10.4161/gmic.2.4.16108

(30) https://www.ncbi.nlm.nih.gov/pubmed/21983070

(31) https://www.ncbi.nlm.nih.gov/pubmed/21683077

(32) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934620/

(33) https://www.ncbi.nlm.nih.gov/pubmed/25251188

(34) https://www.ncbi.nlm.nih.gov/pubmed/25794930

(35) https://www.ncbi.nlm.nih.gov/pubmed/20600016

(36) https://www.ncbi.nlm.nih.gov/pubmed/21988661

(37) https://www.ncbi.nlm.nih.gov/pubmed/20974015/

(38) http://www.tandfonline.com/doi/abs/10.4161/gmic.2.4.16108

(39) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934620/

(40) https://www.ncbi.nlm.nih.gov/pubmed/23566632

(41) http://www.ncbi.nlm.nih.gov/pubmed/26408987

(42) https://www.ncbi.nlm.nih.gov/pubmed/24554471

(43) https://www.ncbi.nlm.nih.gov/pubmed/26408987

(44) https://www.ncbi.nlm.nih.gov/pubmed/23181058

(45) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906699/

(46) https://www.ncbi.nlm.nih.gov/pubmed/23759244

(47) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102282/

(48) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228144//

(49) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937966/

(50) https://www.ncbi.nlm.nih.gov/pubmed/?term=18819774

(51) https://www.ncbi.nlm.nih.gov/pubmed/219080555

(52) https://www.ncbi.nlm.nih.gov/pubmed/21908055

(53) http://www.ashdin.com/journals/JEM/235910/

(54) https://www.ncbi.nlm.nih.gov/pubmed/27632908

(55) https://www.ncbi.nlm.nih.gov/pubmed/27841940

Terms and Conditions

Privacy Policy

Affiliate Disclosure

Disclaimer

25 Powerful Ways to Boost the Mitochondria in Your Brain

Picture of several mitochondria.

It’s becoming increasingly clear that chronic mitochondria dysfunction is one of the main underlying factors that contributes to poor brain function and mental illness. 

Mitochondria are unique structures within every cell of your body. You have trillions and trillions of them, making up approximately 10% of your total body weight.

Mitochondria are considered the “powerhouses of the cell,” generating most of the energy in your body by converting nutrition into adenosine-5’- triphosphate (ATP). ATP is your body’s main source of cellular fuel. You are constantly using it, and your brain needs enough of it to work properly (106-107). 

Your mitochondria are critically important and need to be supported to overcome depression and anxiety, and reach optimal brain and mental health.

Mitochondria are especially abundant in your brain cells and involved in many important biological processes in the brain, including the regulation of free radicals and neurotransmitters.

In fact, monoamine oxidase (MAO), the enzyme responsible for the metabolism of monoamine neurotransmitters, is localized within the outer mitochondrial membrane (91-93). 

So not surprisingly, numerous studies show that there is a correlation between impaired mitochondrial function in the brain and many psychiatric and neurodegenerative diseases, including:

In fact, some researchers are convinced that mitochondrial dysfunction is involved in almost every chronic disease (108-110). 

Mitochondria dysfunction decreases ATP energy production and increases oxidative stress, which are commonly found in the brains of people suffering from brain and mental health disorders.

Cognitive symptoms of mitochondrial dysfunction can also include impairments in attention, executive function and memory (105).

Unfortunately, a number of psychiatric drugs damage the mitochondria and worsen the dysfunction.

But luckily, there are ways to halt and reverse mitochondrial decay.

Below are a number of strategies I’ve used over the years to support my mitochondria.

Supplements and lifestyle changes can improve mitochondrial health by increasing the availability of proteins needed for ATP production.

They also act as antioxidants, assisting the mitochondria in reducing oxidative stress.

Some of the following lifestyle changes and supplements can also increase the number of mitochondria present within the cell.

And you can start using them today to regain optimal brain and mental health.

 

1. Eat Nutrient-Dense, Whole Foods

Dr. Terry Wahls standing in front of her wheelchair.

Eating lots of fresh, nutrient-dense whole foods is an impactful action you can take to power your mitochondria. 

In order to thrive, your mitochondria need phytonutrients, antioxidants, healthy fats and proteins.

Dr. Terry Wahls, MD, clinical professor of medicine at the University of Iowa, is a leading expert on the relationship between nutrition and mitochondrial health.

She was diagnosed with multiple sclerosis (MS) more than a decade ago but reversed the neurodegenerative brain disease by repairing her mitochondria with an intensive nutritional strategy.

She outlines how she recovered her health in her book The Wahls Protocol

Research on her protocol shows that patients witness a “significant improvement in fatigue” (67). 

She recommends eating six to nine cups of vegetables and fruits every day, including green veggies (kale, spinach), brightly colored vegetables (beets, carrots, peppers), and sulfur-rich veggies (broccoli, cauliflower).

My Free Grocery Shopping Guide for Optimal Brain Health contains a bunch of foods that you should be eating on a regular basis for optimal mitochondrial health. 

Dr. Wahls also has a fascinating TED talk that you can watch if you're interested in learning more. 

 

2. Limit Certain Foods and Ingredients

Pizza, burgers and fries. Fast, processed food impairs mitochondria health.

Eating poor-quality foods can also wear down your mitochondria. 

Your mitochondria were not designed to deal with our current food environment and lifestyle habits. 

That’s why you should limit refined sugars, processed flours, industrial oils and trans fats. They can damage your mitochondria and prevent them from properly producing energy.

Dr. Wahls also recommends you avoid all gluten, dairy and soy products for optimal mitochondrial health.

I used to strictly avoid all of these foods and I felt better when I did, but no longer need to since restoring my health.

 

3. Eat More Essential Fats

Healthy fats, including omega-3 fatty acids, help build and strengthen the membranes of your mitochondria. They’ve also been shown to improve mitochondrial function in the brain (5-7). 

That’s why Dr. Wahls recommends eating organic grass-fed beef or wild-caught fish, such as salmon, every day.

Avocados, nuts, seeds, coconut and olive oil are also rich in healthy fats. 

Supplementing with krill oil is another excellent option.

 

4. Exercise

Not surprisingly, exercise strengthens your mitochondria by increasing oxygen and blood flow and activating biochemical pathways that produce new mitochondria (8). 

Runners have more high-functioning mitochondria than non-runners, and strength training and high-intensity interval training also increase the number of mitochondria and improve the efficiency of your existing mitochondria (9, 10).

Exercise can also increase brain-derived neurotrophic factor (BDNF).

 

5. Low-Level Laser Therapy (LLLT)

Low-level laser therapy (LLLT) is a treatment that uses low-level (low-power) lasers or light-emitting diodes (LEDs) to stimulate brain cells, helping them heal and function better. 

There is strong evidence to suggest that LLLT supports the mitochondria. 

Research shows that LLLT reduces oxidative stress and increases the production of ATP energy in mitochondria (39, 40). 

These mitochondrial benefits have also been seen directly within the brain.

Studies show that LLLT increases mitochondrial activity within brain cells, and this leads to beneficial effects in behaviour (41). 

LLLT treatment has also been shown to increase the number of mitochondria, and mitochondrial oxygen usage, within the brain (42, 43).

I have used these two LLLT devices myself at home to support my mitochondria and boost my brain function:

  • Optimal 1000 Brain Photobiomodulation Therapy Light (Combo Red/NIR) - This is a powerful device that shines 660 nm of red light and 850 nm of infrared light. You can shine it on your forehead for 5 minutes every day. You can also shine it on other parts of your head and on your entire body, including your thyroid, thymus gland and gut.

  • Vielight Neuro Duo – This is a transcranial-intranasal headset with 810 nm of near infrared light. It penetrates deeper into brain tissue and is absorbed better by the central nervous system. If you decide to get this one, you can use the coupon code JORDANFALLIS for a 10% discount. Some research has shown a 20-fold higher efficiency of light delivery to the deep brain through the nose instead of transcranial application (125).

You can learn more about LLLT in this post

You should also limit your exposure to artificial blue light, as excessive blue light exposure can also wear down your mitochondria. You can learn more about the risks of too much blue light in this post

Click here to subscribe

6. Resveratrol

Resveratrol is a beneficial antioxidant compound found in grapes and red wine. 

Not only does it increase BDNF levels, but it also activates the SIRT1 gene. This gene triggers a number of positive biochemical reactions that protect and improve the functioning of your mitochondria. Caloric restriction and intermittent fasting also trigger the SIRT1 gene (11-13).

In 2006, Harvard researchers found that resveratrol increases lifespan by protecting the mitochondria (14).

Resveratrol is included in the Optimal Energy supplement.

 

7. Caloric Restriction and Intermittent Fasting

Restricting your calories is one the best actions you can take to improve mitochondrial function.

Studies show that eating less food reduces the demand and damage on your mitochondria. 

But reducing calories is tough to do and absolutely no fun. 

So you can do intermittent fasting instead. 

Fasting activates your mitochondria and triggers autophagy, which is an intracellular process that essentially allows your mitochondria to clean themselves by removing unwanted and damaged debris, proteins and reactive oxygen species (1, 2, 4).

This process has been shown to reduce the risk of cancer, Parkinson’s disease and Alzheimer’s disease (3). 

 

8. Nicotinamide Adenine Dinucleotide (NADH)

NADH is a naturally-occurring compound found in the cells of all living organisms.

It plays a key role in the production of energy within the cell and is highly concentrated within your mitochondria (45). 

Depletion of NADH has been linked to a number of diseases, including depression, chronic fatigue syndrome, Alzheimer’s and Parkinson’s.

But stabilized oral NADH has been shown to improve all of these conditions (46, 47, 48). 

Although I don’t take it anymore, I’ve witnessed a beneficial effect from supplementing with NADH.

LLLT is also known to increase NADH in your mitochondria. 

Check out this article for other ways to increase NAD.

 

9. Ketogenic Dieting

A ketogenic diet is a very low-carb diet. 

When you restrict carbohydrate-rich foods, your body enters ketosis.

Ketosis is a metabolic state in which your body and brain run on fatty acids and “ketones” instead of glucose (36).

Ketones are an alternative source of energy for your brain cells and they support your mitochondria. 

When your mitochondria are dysfunctional, following a ketogenic diet can be an effective strategy to fuel the mitochondria. 

When mitochondria are fueled by ketones instead of glucose, their ability to produce ATP is enhanced and free-radical byproducts are reduced.
— Dr. Jong Rho, MD, Professor of Pediatrics and Clinical Neurology at the Alberta Children’s Hospital

Ketogenic diets may help treat many different brain and mental health diseases including Alzheimer’s, Parkinson’s, epilepsy and autism. 

Exogenous ketones can also help you get into ketosis and experience the mitochondrial-boosting effects of ketones very quickly.

 

10. B Vitamins

B vitamins play an essential role in maintaining mitochondrial function.

In fact, your mitochondria will be compromised if you have a deficiency of any B vitamin (37). 

Deficiency is more likely if you take certain medications

Vitamin B1, B2, B3, B5, B6 and B12 are all included in the Optimal Energy supplement for this reason.

Click here to subscribe

11. Ribose

Ribose is a five carbon sugar created naturally by your body.

Even though it’s a sugar, research suggests it does not raise blood sugar levels.

Instead, your body stores it in the mitochondria (49, 50). 

Ribose is used by the mitochondria to produce ATP and if you don’t have enough, you’ll experience low energy (51). 

Chronic stress can deplete ribose, and certain conditions have been linked to chronic ribose deficiency, including depression and chronic fatigue syndrome.

People can supplement with ribose if they struggle with these disorders because it can help reduce mental and physical lethargy (52, 53).

Ribose is also included in Optimal Energy.

 

12. Coenzyme Q10 (CoQ10)

Coenzyme Q10 (CoQ10) is an antioxidant molecule found in every cell of your body.

It’s particularly concentrated in the mitochondria, playing a key role in the production of energy.

It also protects the mitochondria from oxidative damage. 

Without CoQ10, your body cannot synthesize ATP because CoQ10 is an essential component of the mitochondrial electron transport chain.

Many doctors are unaware that CoQ10 is an excellent treatment for many brain health issues, including depression, chronic fatigue syndrome, and Alzheimer’s disease

Low levels of CoQ10 can cause brain fog, mental fatigue, difficulty concentrating, memory lapses, depression and irritability (68-70). 

Researchers have found that CoQ10 levels are significantly lower in the depressed patients (71). 

Unfortunately, chronic oxidative stress and medications can further deplete CoQ10

But supplementing with CoQ10 can increase your mitochondrial energy production and reduce symptoms of depression and chronic fatigue (71). 

Food sources with high natural concentrations of CoQ10 include organic red palm oil and grass-fed beef heart (72, 73). 

But supplementing with it will give you a more significant mitochondrial boost.

 

13. Pyrroloquinoline quinone (PQQ)

Pyrroloquinoline quinone (PQQ) is a vitamin-like enzyme and potent antioxidant found in plant foods.

It has a wide range of brain health and mitochondrial benefits.

It’s been shown to preserve and enhance memory, attention, and cognition by protecting the mitochondria from oxidative damage.

It also promotes the growth of new mitochondria in the brain (56-59). 

Since it helps grow new mitochondria, it may help you if you suffer from depression, since fewer mitochondria have been found in people with depression (63). 

Reactive nitrogen species (RNS) and reactive oxygen species (ROS) cause severe stress on brain cells and mitochondria.

PQQ has also been shown to suppress RNS and ROS (60-62). 

Researchers have also found that supplemental PQQ can be neuroprotective by increasing mitochondrial activity levels (64-66). 

I personally never really noticed much of anything from PQQ. So I don’t take it anymore and didn’t include it in Optimal Energy.

 

14. Magnesium

Magnesium is a vital mineral within your body.

Mitochondria are considered magnesium “storage units” because they hold onto a lot of your body’s magnesium. 

Magnesium also protects the mitochondria and plays a role in the production and transfer of ATP within the mitochondria.

And research shows that if you have a deficiency in magnesium, your brain cells will have fewer mitochondria, and they will be less healthy (54, 55). 

This is just another reason to supplement with magnesium every day.

 
Scientific representation of brain and brain blood flow.

Carnitine is an amino acid that improves mitochondrial activity and plays an important role in energy production.

It’s known to transport fatty acids directly into the mitochondria of your brain cells. 

It’s also required to produce ATP and deficiencies are associated with reduced mitochondrial function in the brain (74). 

Supplementing with carnitine makes it easier for fatty acids to cross your blood-brain barrier and nourish the mitochondria within your brain. This can improve your mood, memory and energy levels.

Several studies show that carnitine eases depressive symptoms and improves quality of life in patients with chronic depression (75-78). 

And individuals with autism often have reduced levels of carnitine within their brain (79). 

Carnitine is synergistic with Alpha Lipoic Acid (ALA), meaning that when you take them together, they are more effective at supporting the mitochondria in your brain.

ALA is a mitochondrial enzyme and antioxidant. It is fat soluble and can easily cross your blood-brain barrier.

It’s been shown to improve cognition by reducing oxidative stress in the brain.

It also protects existing mitochondria and creates new mitochondria in the brain (80, 101).

Both ALA and carnitine are included together in Optimal Energy.

Click here to subscribe

16. Thiamine

Thiamine, also known as Vitamin B1, is an essential water-soluble nutrient that cannot be made by the body.

It’s used in nearly every cell in the body and it’s especially important for supporting energy levels and mitochondrial functioning in the brain.

It’s also required by nerve cells and other supporting cells in the nervous system.

Research shows that thiamine deficiency induces oxidative stress, resulting in mitochondrial abnormalities in the brain (21-22).

Healthy food sources of thiamine include green peas, beef liver, asparagus, pecans, spinach, sunflower seeds, macadamia nuts, oranges, cantaloupe and eggs. 

These foods are included in my Free Grocery Shopping Guide for Optimal Mental Health.

Thiamine is also included in Optimal Energy.

 

17. Creatine

Creatine is a molecule produced in the body and found in foods, particularly meat, eggs, and fish.  

Creatine is also available as a supplement.

Athletes, bodybuilders, wrestlers, sprinters often take extra creatine to gain more muscle mass.

It’s an incredibly well-researched supplement and safe to take regularly. 

Supplementing with creatine can also support the brain.

It's been shown to have neuroprotective effects. It rapidly produces energy to support brain cell function.

Researchers have also found that creatine supplementation improves function of mitochondria in the brain (25).

 

18. Curcumin

Curcumin is the most heavily researched compound within turmeric, the spice that gives curry its yellow colour.

Curcumin protects mitochondria and prevents mitochondrial dysfunction in the brain (111-113).

Curcumin can be found in both Optimal Energy and Optimal Antiox.

 

19. Malic Acid

Malic acid, also known as malate, is an intermediate of the Krebs cycle.

It’s a key step in the pathway of energy production by the mitochondria.

And it has a number of health benefits because it improves mitochondrial function.

Malate supplementation has been shown to increase the availability of NAD+, which is necessary for producing ATP.

Malate also increases NADPH levels, which is a fundamental antioxidant in the body that promotes mitochondrial function (114).

That’s why I’ve included malic acid in the Optimal Energy supplement.

 

20. Niacinamide

Niacinamide, also known as nicotinamide, is a vitamin found in foods.

It’s also often taken as a supplement.

Niacinamide is the precursor to NAD+ and therefore supplementation can increase levels of this molecule and improve mitochondrial function.

Researchers have found that niacinamide prevents energy depletion in the brain (115).

It also improves the mitochondrial quality of brain cells by inducing autophagy and causing dysfunctional mitochondria to fragment (116).

Click here to subscribe

21. N-Acetyl-Cysteine

N-Acetyl-Cysteine (NAC) is a modified form of the amino acid cysteine.

It’s also the precursor to glutathione, your body’s master antioxidant.

Nowadays, we’re exposed to so many environmental toxins, which cause oxidative stress in the body and deplete our reserves of cysteine and glutathione.  

But supplementing with NAC can increase and normalize your cysteine and glutathione levels. 

This can combat and reduce oxidative stress in your brain, which can then help treat several mental illnesses.

NAC can also help support your mitochondria.

In one study, NAC treatment for 9 weeks reduced oxidative damage to the mitochondria (117).

And in multiple cell studies, NAC improved mitochondrial function by reducing oxidative stress (118-119).

 

22. Succinic acid

Succinic acid, also known as succinate, is an intermediate molecule of the Krebs cycle that plays a significant role in the electron transport chain.

It can be purchased as a supplement to boost energy production by the mitochondria.

Succinic acid has been shown to prevent structural and functional damage to the mitochondria caused by oxidative stress (120).

And in brain cells that have mitochondrial dysfunction, succinic acid supplementation improved mitochondrial functioning by increasing glucose and oxygen usage. This led to increased levels of ATP energy (121).

For this reason, succinic acid is in the Optimal Energy supplement.

 

23. EGCG

Epigallocatechin-3-Gallate (EGCG) is the main polyphenol found in green tea.

It’s been shown to have anti-inflammatory and neuroprotective effects.

EGCG accumulates within the mitochondria and activates a number of proteins related to mitochondrial function (122-124).

I personally drink organic green tea regularly, usually in place of coffee on days when I’m relaxing.

However, it’s important to keep in mind that the body isn't very good at absorbing EGCG and distributing it to the brain and other tissues.

That's why researchers often use large dosages of concentrated EGCG in their studies instead of green tea.

But unfortunately, large dosages of concentrated EGCG have been shown to cause liver toxicity.

So you could supplement with large dosages of concentrated EGCG and see some benefits.

But you'd be damaging your liver at the same time.

Not good.

So what should you do? How do you absorb EGCG and get the amazing benefits of it without damaging your liver?

You take it with Vitamin C.

Research shows that you can enhance the absorption and availability of EGCG by taking it with Vitamin C (9).

That's why the Optimal Antiox supplement includes a small and safe amount of EGCG, plus 500 mg of Vitamin C.

This significantly enhances the absorption of EGCG, and ensures you get all the brain and mental health benefits of EGCG (without the harm).

 

24. Citicoline

Citicoline (also known as CDP-Choline) is one of the most bioavailable forms of choline, an essential B vitamin.

You need to get choline from food, but most people do not get enough because very few foods in the Western diet contain high levels of it.

That’s why supplementation is often necessary for optimal brain health.

Citicoline is a supplemental form of choline that has anti-inflammatory and neuroprotective effects.

Research shows that citicoline slows down the aging of mitochondria in the brain (125).

It also significantly enhances mitochondrial energy production and increases ATP levels in the frontal lobe of the brain (125).

Citicoline significantly improves my focus and mental energy.

You can also find some choline in foods such as beef liver and egg yolks, but the effects of Citicoline are much more noticeable and immediate because it quickly passes the blood-brain barrier and supports your brain.  

Make sure you read this article to learn more about the remarkable benefits of Citicoline.

 

25. Ginkgo Biloba

Ginkgo Biloba is a plant that has been used in China for thousands of years to treat a number of health problems.

It’s one of the top-selling natural supplements in the world, and it’s even a prescription herb in Germany.

Ginkgo Biloba is most commonly used to improve brain health because it increases brain blood flow and improves memory, mood, mental energy, and attention in both healthy and unhealthy individuals.

It even reduces the risk of dementia and Alzheimer’s disease!

Researchers have discovered that one of the ways it supports brain function is by improving mitochondrial function and increasing the production of ATP in brain cells (126-127).

It even restores ATP levels after mitochondrial damage (128).

Ginkgo Biloba is included in the Optimal Brain supplement.

 

Conclusion

Picture of mitochondrion, the energy producer of brain cells.

Paying attention to your mitochondria is crucial for optimal brain and mental health.

Luckily there are a number of dietary and lifestyle habits that can protect and support mitochondrial function.

The following steps will ensure your body and brain have healthier and more abundant mitochondria: 

  • Take Optimal Energy. It’s an all-in-one mitochondrial supplement. It includes the 17 best natural compounds proven to boost mitochondrial functioning in the brain.

  • Eat nutrient-dense, whole foods, including plenty of fruits and vegetables. Download my free food guide for a shopping list of the best foods to eat.

  • Limit refined sugars, processed flours, industrial oils, trans fats, gluten and processed dairy.

  • Eat organic grass-fed beef and wild-caught fish, or supplement with krill oil.

  • Exercise

  • Try LLLT

  • Restrict calories and/or fast intermittently

  • Follow a cyclic ketogenic diet and/or take exogenous ketones

If you follow these strategies, there’s no doubt that you can improve your mitochondrial health and naturally restore your mood and energy levels.

Please share this post with one of your friends or family members who you think might benefit from protecting and supporting their mitochondria, because it really is an underappreciated and unknown aspect of optimal brain and mental health. 

 
Click here to subscribe

Live Optimally,

Jordan Fallis

Connect with me

References:

(1) http://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-10-63

(2) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630798/

(3) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630798/

(4) http://www.hindawi.com/journals/jar/2011/807108/

(5) http://www.ncbi.nlm.nih.gov/pubmed/24396061

(6) http://www.ncbi.nlm.nih.gov/pubmed/24972878

(7) https://lipidworld.biomedcentral.com/articles/10.1186/1476-511X-11-142

(8) http://www.nutritionandmetabolism.com/content/10/1/63

(9) https://www.masscfids.org/resource-library/13-basic-information/302-mitochondrial-dysfunction-post-exertional-malaise-and-cfsme

(10) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883043/

(11) http://www.ncbi.nlm.nih.gov/pubmed/15749705

(12) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2492662/

(13) http://www.ncbi.nlm.nih.gov/pubmed/24449278

(14) http://www.cell.com/cell/abstract/S0092-8674(06)01428-0?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867406014280%3Fshowall%3Dtrue

(15) http://www.nrjournal.com/article/S0271-5317(03)00234-3/abstract

(16) http://www.ncbi.nlm.nih.gov/pubmed/20840838

(17) http://www.nature.com/tp/journal/v5/n1/full/tp2014131a.html

(18) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462011000400003

(19) http://www.ncbi.nlm.nih.gov/pubmed/22776356

(20) http://www.fasebj.org/content/19/12/1657.abstract

(21) http://www.ncbi.nlm.nih.gov/pubmed/6493495

(22) http://link.springer.com/article/10.1007/s13105-013-0242-y

(23) http://www.ncbi.nlm.nih.gov/pubmed/16102804

(24) http://www.healio.com/endocrinology/practice-management/news/online/%7B4b5c8b84-70c2-4928-a7b0-88f24f50d609%7D/vitamin-d-supplementation-enhanced-mitochondrial-function-lessened-fatigue

(25) http://www.ncbi.nlm.nih.gov/pubmed/12657421

(26) http://www.ncbi.nlm.nih.gov/pubmed/21423579

(27) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100547/

(28) http://www.ncbi.nlm.nih.gov/pubmed/15183071

(29) http://www.fasebj.org/content/20/2/269.abstract

(30) https://biolres.biomedcentral.com/articles/10.1186/0717-6287-47-74

(31) http://www.ncbi.nlm.nih.gov/pubmed/26278015

(32) http://www.ncbi.nlm.nih.gov/pubmed/19211721

(33) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670924/

(34) http://www.ncbi.nlm.nih.gov/pubmed/26365487

(35) http://www.ncbi.nlm.nih.gov/pubmed/21061051

(36) http://www.ncbi.nlm.nih.gov/pubmed/17332207

(37) http://www.ncbi.nlm.nih.gov/pubmed/16765926

(38) http://www.ncbi.nlm.nih.gov/pubmed/2476986/

(39) http://www.ncbi.nlm.nih.gov/pubmed/10365442/

(40) http://www.ncbi.nlm.nih.gov/pubmed/6479342/

(41) http://www.ncbi.nlm.nih.gov/pubmed/17693028/

(42) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945284/?report=classic

(43) http://www.ncbi.nlm.nih.gov/pubmed/22850314

(44) http://www.ncbi.nlm.nih.gov/pubmed/23675984

(45) http://www.nadhenergy.eu/what-does-nadh-do.html

(46) http://www.ncbi.nlm.nih.gov/pubmed/10071523

(47) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346380/

(48) http://www.ncbi.nlm.nih.gov/pubmed/15134388

(49) http://lifewave.com/pdf/ThetaNutrition/%283%29Enhancing-Mitochondrial-Function-With-D-Ribose.pdf

(50) http://thealbanyjournal.com/2012/01/energize-yourself-with-d-ribose/

(51) http://lifewave.com/pdf/ThetaNutrition/%283%29Enhancing-Mitochondrial-Function-With-D-Ribose.pdf

(52) http://lifewave.com/pdf/ThetaNutrition/%283%29Enhancing-Mitochondrial-Function-With-D-Ribose.pdf

(53) http://www.ncbi.nlm.nih.gov/pubmed/17109576

(54) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790427/

(55) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1172515/

(56) http://www.ncbi.nlm.nih.gov/pubmed/19861415

(57) http://www.humanclinicals.org/biopqq/

(58) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212345/

(59) http://www.ncbi.nlm.nih.gov/pubmed/18591768

(60) http://www.ncbi.nlm.nih.gov/pubmed/20178828

(61) http://www.ncbi.nlm.nih.gov/pubmed/12383230

(62) http://www.ncbi.nlm.nih.gov/pubmed/19026989

(63) http://www.ncbi.nlm.nih.gov/pubmed/21159390

(64) http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0021779

(65) http://www.ncbi.nlm.nih.gov/pubmed/19699263

(66) http://www.ncbi.nlm.nih.gov/pubmed/16709402

(67) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011484/

(68) http://www.ncbi.nlm.nih.gov/pubmed/23313551

(69) http://www.ncbi.nlm.nih.gov/pubmed/25386668

(70) http://www.ncbi.nlm.nih.gov/pubmed/21799249

(71) http://www.ncbi.nlm.nih.gov/pubmed/20010493

(72) http://coconutresearchcenter.org/hwnl_4-2.htm

(73) http://www.westonaprice.org/modern-diseases/coenzyme-q10-for-healthy-hearts/

(74) http://lpi.oregonstate.edu/mic/dietary-factors/L-carnitine

(75) http://www.ncbi.nlm.nih.gov/pubmed/12047496

(76) http://www.ncbi.nlm.nih.gov/pubmed/16316746

(77) http://www.ncbi.nlm.nih.gov/pubmed/21443422

(78) http://www.ncbi.nlm.nih.gov/pubmed/17543140

(79) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382850/

(80) http://www.lifeextension.com/magazine/2011/8/Lipoic-Acid-Reverses-Mitochondrial-Decay/Page-01

(81) http://www.nutritionandmetabolism.com/content/10/1/63

(82) http://www.ncbi.nlm.nih.gov/pubmed/16815381

(83) http://www.ncbi.nlm.nih.gov/pubmed/18979198

(84) http://www.ncbi.nlm.nih.gov/pubmed/19664343

(85) http://www.ncbi.nlm.nih.gov/pubmed/18428021

(86) http://www.ncbi.nlm.nih.gov/pubmed/11579422

(87) http://www.ncbihttp://www.ncbi.nlm.nih.gov/pubmed/23650447nlm.nih.gov/pubmed/23650447

(88) http://www.ncbi.nlm.nih.gov/pubmed/16027739

(89) http://www.ncbi.nlm.nih.gov/pubmed/18177933

(90) http://www.ncbi.nlm.nih.gov/pubmed/18235426

(91) http://psych.lf1.cuni.cz/zf/publikace/b005.pdf

(92) http://www.ncbi.nlm.nih.gov/pubmed/21414088

(93)https://www.researchgate.net/publication/228683547_Common_aspects_of_neuroplasticity_mood_disorders_and_mitochondrial_functions

(94) http://www.pnas.org/content/112/50/15486.full.pdf

(95) http://www.nature.com/tp/journal/v4/n6/full/tp201444a.html

(96) http://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-015-0310-y

(97) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640606/

(98)https://www.researchgate.net/publication/221747050_Corticosterone_reduces_brain_mitochondrial_function_and_expression_of_mitofusin_BDNF_in_depression-like_rodents_regardless_of_exercise_preconditioning

(99)http://hypotyreos.info/attachments/079_Mitokondriell%20dysfunktion%20i%20depressiva%20sjukdomar.pdf

(100) http://www.ncbi.nlm.nih.go v/pmc/articles/PMC4382850/

(101) http://www.ncbi.nlm.nih.gov/pubmed/17605107

(102) http://www.ncbi.nlm.nih.gov/pubmed/24189435

(103) http://www.sciencedirect.com/science/article/pii/S0925443909002427

(104) http://www.ncbi.nlm.nih.gov/pubmed/20114042

(105) http://archpsyc.jamanetwork.com/article.aspx?articleid=210694

(106) https://www.masscfids.org/resource-library/13-basic-information/302-mitochondrial-dysfunction-post-exertional-malaise-and-cfsme

(107) http://www.umdf.org/site/c.8qKOJ0MvF7LUG/b.7934627/k.3711/What_is_Mitochondrial_Disease.htm

(108) http://www.ncbi.nlm.nih.gov/pubmed/17239370

(109) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566449/

(110) https://riordanclinic.org/wp-content/uploads/2015/01/mitochondria-and-cancer-1.pdf

(111) https://accelerating.org/articles/curcumin.html

(112) https://www.ncbi.nlm.nih.gov/pubmed/23422877

(113) https://www.ncbi.nlm.nih.gov/pubmed/26254982

(114) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0058345

(115) https://www.ncbi.nlm.nih.gov/pubmed/10566977

(116) https://www.ncbi.nlm.nih.gov/pubmed/19473119

(117) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312826/

(118) https://www.ncbi.nlm.nih.gov/pubmed/17917164

(119) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726696/

(120) https://www.ncbi.nlm.nih.gov/pubmed/3032929

(121) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430749/

(122) https://www.ncbi.nlm.nih.gov/pubmed/26731017

(123) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670924/

(124) https://www.ncbi.nlm.nih.gov/pubmed/16797120

(125) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824764/

(126) https://www.cambridge.org/core/journals/international-psychogeriatrics/article/mitochondrial-effects-of-ginkgo-biloba-extract/A5F444770B1B281798572D608A74DC20

(127) https://www.ncbi.nlm.nih.gov/pubmed/17977008

(128) https://www.frontiersin.org/articles/10.3389/fphar.2015.00206/full

Terms and Conditions

Privacy Policy

Affiliate Disclosure

Disclaimer