When I went to the doctor five years ago for help with my concussion symptoms and mental health challenges, he offered me two options – addictive sleeping pills or expensive antidepressants.
That was it.
I was left in the dark.
I had no other options and nowhere to turn, so I had to take the medication.
Five years later, I now know there are many better solutions. The drugs that your doctors give you are not optimal – far from it.
What's N-Acetylcysteine? How Can It Help The Brain?
Glutathione is a powerful antioxidant that supports liver detoxification and reduces free radicals in the body.
Over the past 30 years, high doses of NAC have been used in emergency rooms to combat acetaminophen (Tylenol) toxicity (1, 2).
But there is also an overwhelming amount of evidence that NAC can help treat a number of neurological and psychiatric disorders, and it has personally played a huge role in my recovery from mental illness and post-concussion syndrome.
A systematic review of all of the evidence suggests that there is favourable evidence supporting NAC in the treatment of the following conditions (4, 6, 18, 19):
NAC also reduces the severity of mild traumatic brain injury in soldiers, and animal studies show that it can improve cognition after moderate traumatic brain injury (5).
Disorders such as anxiety and attention deficit hyperactivity disorder have preliminary evidence but require larger studies (4, 6).
Mike Cernovich has even wrote about how severe mental illness runs in his family and how NAC helped him overcome his depression and anxiety.
Overall, it’s clear to me that NAC should be a first-line treatment for mental illness, along with these three other critical nutrients. The fact that NAC improves so many different mental disorders tells me that it’s much closer to treating the root cause of these brain afflictions than standard psychiatric care.
My recommendation: I used to take 1200 mg of this NAC supplement every day to manage my long-term mental health. It was key to my recovery, but I don’t need to take nearly as much anymore after doing neurofeedback. Studies show that people benefit from taking anywhere between 500 mg to 3000 mg daily or every other day but I find that many of my clients actually do better when they take a lower dose. I now take and recommend the 250 mg of NAC found in the Optimal Antiox supplement because it also contains a number of other antioxidants and nutrients that can support your brain and mental health. It also contains leucine. When taken with NAC, leucine prevents mercury from being reabsorbed into the central nervous system.
How is it so effective at treating all these mental conditions?
First of all, it's important to note that NAC seems to target biological pathways that are common across all mental disorders. And this is something mainstream medicine and the pharmaceutical industry would rather ignore. NAC isn't patentable. They would rather focus on producing, patenting and marketing new drugs for many different disorders. There’s lots more money in that.
Here are some possible explanations for its effectiveness:
NAC has anti-inflammatory properties, and inflammation has been linked to depression and other mental health disorders (12, 13).
NAC has also been shown to successfully cross the blood-brain-barrier and raise glutathione levels in the brain. Low levels of glutathione in the brain have been linked to a number of psychiatric disorders (8-11, 17-19, 24).
High levels of oxidative stress have been identified in the brains of patients with a variety of psychiatric illnesses. Increasing brain glutathione by supplementing with NAC can help reduce this oxidative stress and protect neurons from oxidative damage (20-23, 25).
Lastly, NAC may be having beneficial effects on patients by reducing glutamate, a major excitatory neurotransmitter in the brain that can lead to overstimulation (14-16, 26).
Therefore, if you take NAC, you're giving your body an efficient way to soak up excess glutamate, and reducing oxidative stress and inflammation over time by giving it glutathione. As a result, this helps alleviate a number of different mental health problems.
Below, I’ll lay out some of the research exploring NAC as a possible treatment for five mental health problems. Feel free to skip to your condition to learn about it.
The current treatments for many of these disorders are sub-optimal. And most established drugs have many negative side effects. Yet I couldn’t find any evidence suggesting that NAC causes negative effects.
Depression and Bipolar Disorder
Here is some of the research looking into NAC as a possible treatment for depression and bipolar disorder:
A randomized controlled trial examined 149 individuals with moderate depression. They received two grams of NAC or placebo. Before treatment, the estimated mean depression score was 19.7. At the end of the 8-week study, the score had decreased to 11.1. Individuals who received NAC witnessed improvements in functioning and quality of life (27).
Another randomized controlled trial looked at 75 patients with bipolar disorder. Two grams of NAC or placebo was given for 6 months. At the end of this period, the group who received NAC saw a reduction in their depression and significant improvements in their global, social and occupational functioning. The improvements were rated as “medium to high” and it was concluded that "NAC is a safe and effective augmentation strategy for depressive symptoms” (28).
Several other studies have examined the effects of NAC on bipolar disorder (including mania) and found that two grams of NAC daily can significantly improve and even cause full remission of both depressive and manic symptoms (29-31).
It’s important to note that some of these studies lasted 6 months, which is a very long time for randomized control trials. And all of the studies had beneficial effects and zero severe side effects. That’s quite impressive, especially considering that pharmaceutical companies have spent billions of dollars trying to find a “cure” for depression and bipolar disorder and don’t have much to show for it.
All of the above research makes sense in light of a meta-analysis that found that patients with bipolar disorder have significantly higher levels of oxidative stress and glutamate in their brain.
A number of mood-stabilizing medications aim to decrease glutamate, yet they come with numerous side effects (14-16, 26, 27, 32, 33).
And as I've discussed before, certain antidepressants can deplete glutathione, which further increases oxidative stress.
NAC is definitely a better and healthier long-term option.
Substance abuse and addiction are very costly. Yet there are hardly any efficient treatments that prevent relapse.
In a small study, 13 people abstaining from cocaine were given 2400 mg of NAC or placebo over two days. The participants who received NAC witnessed a significant reduction in their withdrawal symptoms and cravings for cocaine (34). Follow-up studies also showed that NAC reduced desire and interest in cocaine (35, 36).
Smokers voluntarily reduce their cigarette use by around 25% after two weeks of supplementing with 2400 mg of NAC (37, 65).
And it’s not just addiction to drugs. NAC also shows promise for the treatment of gambling addiction. A randomized control trial with 27 pathological gamblers showed that gamblers who supplemented with NAC scored 60% lower on the “Obsessive Compulsive Scale for Pathological Gambling." (38).
Obsessive-Compulsive Disorder (OCD)
Not surprisingly, there are brain similarities among people who suffer from addiction and obsessive–compulsive disorder (OCD).
Just like addiction, higher levels of oxidative stress and glutamate are found in people with OCD (39-44).
The standard treatment for OCD is a combination of antidepressants and psychotherapy. But around 20% of patients don’t get better with this combination, and many suffer from a variety of drug side effects (45).
Since NAC is inexpensive, widely available, and has no side effects, it’s clear that it has significant advantages for patients. Just don’t expect pharmaceutical reps to bring this to the attention of your doctor. You’ll have to find it yourself.
Autism is a touchy subject. So let me start out by saying that NAC will not cure autism. Autism has many different causes and aggravators.
However, NAC will likely improve some autistic symptoms.
Multiple studies suggest that NAC is a well-tolerated treatment for autistic individuals and can reduce their irritability (46-48).
Like the disorders above, research has found that autistic individuals have higher levels of oxidative stress and lower levels of the antioxidant glutathione in their brains, making it likely that NAC will help them (49-55).
There is also lots of evidence suggesting that too much glutamate in the brain contributes to autistic symptoms. As discussed earlier, glutamate in a major excitatory neurotransmitter in the brain. It is also the precursor to GABA, a calming neurotransmitter that reduces anxiety.
There is an enzyme that converts glutamate to GABA, and researchers have found that this enzyme is lower in individuals on the autism spectrum. This leads to more glutamate and less GABA, and therefore much more excitation. Not surprisingly then, glutamate antagonists (e.g. NAC) have been shown to reduce symptoms of autism, bringing them more into balance (56-60).
Since oxidation and glutamate are abnormally elevated in persons with autism, NAC can kill two birds with one stone by providing an antioxidant effect and reducing glutamate levels in the brain of autistic individuals.
The last mental disorder I’m going to explore is schizophrenia. There is a good amount of research suggesting that NAC can help with this condition as well.
Researchers gave 2 grams of NAC to schizophrenic patients during a large six-month randomized control trial. The participants who received NAC experienced improvements in their symptoms, and many of them did not experience improvements from other treatments. They demonstrated improvements in insight, self-care, social interaction, motivation, and stabilization of mood. Follow-up studies found similar results (62, 63, 70).
I found one study that explored NAC’s ability to change schizophrenic patient’s electroencephalogram (EEG) synchronicity – a measure of electrical activity within the brain that I discussed in my post about neurofeedback (69).
I also found a case report of a young woman with treatment-resistant schizophrenia who showed significant improvements in symptoms by taking just 600 mg of NAC every day (64).
This makes sense considering there is an expanding body of evidence suggesting oxidative stress occurs in individuals with schizophrenia. Some research shows that the more oxidative stress a schizophrenic patient experiences, the worse their symptoms get. And several studies indicate that NAC may benefit schizophrenics by increasing glutathione and reducing glutamate (61, 71-74).
Overall, oxidation and glutamate are often abnormally elevated in people with a wide range of neurological and psychiatric disorders.
NAC may correct these underlying problems by generating the antioxidant glutathione and reducing the excitatory neurotransmitter glutamate.
I would definitely advise people suffering from depression, bipolar disorder, OCD, drug addiction or autism to start taking it. It's very safe. See how it affects you. If it helps, keep taking. If not, then try something else.
Many of the studies also suggested that NAC enhances the effectiveness of psychiatric medications. So if you're already on medication, they will likely work well together. There appears no downside in giving it a try.
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About the Author
Jordan Fallis is a health and science journalist and researcher, and the founder of Optimal Living Dynamics, a website that has helped more than 1.5 million people improve their brain and mental health. His work has been featured in the Canadian Broadcast Corporation, the Canadian Medical Association Journal, and the Canadian Pharmacists Journal. Jordan has also interviewed, consulted, and worked with more than one hundred medical doctors, health practitioners and leading researchers. He spends a lot of time scouring medical research, writing about what he finds, and putting the theories to the test on himself.
2. Atkuri, K.R., et al. “N-Acetylcysteine — a safe antidote for cysteine/glutathione deficiency”. Current Opinion in Pharmacology Vol. 7, No. 4 (2007): 355–359.
20. Andreazza, A.C., et al. “Oxidative stress markers in bipolar disorder: a meta-analysis”. Journal of Affective Disorders Vol. 111, No. 2–3 (2008): 135–144.
21. Kim, H.K., et al. “Oxidation and nitration in dopaminergic areas of the prefrontal cortex from patients with bipolar disorder and schizophrenia”. Journal of Psychiatry & Neuroscience Vol. 39, No. 1 (2014): 130155.
22. Wang, J.F., et al. “Increased oxidative stress in the anterior cingulate cortex of subjects with bipolar disorder and schizophrenia”. Bipolar Disorders Vol. 11, No. 5 (2009): 523–529.
23. Gawryluk, J.W., et al. “Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders”. The International Journal of Neuropsychopharmacology Vol. 14, No. 1 (2011): 123–130.
24. Holmay, M.J., et al. “N-Acetylcysteine boosts brain and blood glutathione in Gaucher and Parkinson diseases”. Clinical Neuropharmacology Vol. 36, No. 4 (2013): 103–106.
25. Gawryluk, J.W., et al. “Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders”. The International Journal of Neuropsychopharmacology Vol. 14, No. 1 (2011): 123–130
26. Gigante, A.D., et al. “Brain glutamate levels measured by magnetic resonance spectroscopy in patients with bipolar disorder: a meta-analysis”. Bipolar Disorders Vol. 14, No. 5 (2012): 478–487.
27. Berk, M., et al. “The efficacy of N-acetylcysteine as an adjunctive treatment in bipolar depression: an open label trial”. Journal of Affective Disorders Vol. 135, No. 1–3 (2011): 389–394.
29. Magalhães, P.V., et al. “N-Acetylcysteine for major depressive episodes in bipolar disorder”. Revista Brasileira de Psiquiatria Vol. 33, No. 4 (2011): 374–378.
30. Magalhães P.V., et al. “N-Acetyl cysteine add-on treatment for bipolar II disorder: a subgroup analysis of a randomized placebo-controlled trial. Journal of Affective Disorders Vol. 129, No. 1–3 (2011): 317–320.
31. Magalhães, P.V., et al. “A preliminary investigation on the efficacy of N-acetyl cysteine for mania or hypomania”. The Australian and New Zealand Journal of Psychiatry Vol. 47, No. 6 (2013): 564–568.
69. Carmeli, C., et al. “Glutathione precursor N-acetyl-cysteine modulates EEG synchronization in schizophrenia patients: a double-blind, randomized, placebo-controlled trial”. PLoS One Vol. 7, No. 2 (2012): e29341.
Medically reviewed by Dr. Fred Hui, MD, CCFP, CAFC