A Powerful Protocol Proven to Help Reverse Brain Damage

I’ve been reading a lot about brain damage and chronic traumatic encephalopathy (CTE) in retired NFL football players lately.

While doing so, I came across an interesting study by Dr. Daniel Amen, MD, titled “Reversing brain damage in former NFL players: implications for traumatic brain injury and substance abuse rehabilitation.

In the study, thirty retired NFL players who had brain damage and cognitive dysfunction followed a brain-healthy protocol (which I outline below in this post).

After following the protocol for six months, the former NFL players had increased blood flow to the brain and significant increases in performance. 

Neuropsychological testing showed that they had significant improvements in attention, memory, reasoning, and information processing. 

The NFL players themselves also self-reported subjective increases in memory, attention, mood, motivation, and sleep.

It just so happens that a lot of the supplements and therapies used in this protocol have also improved my mental health and supported my brain after suffering multiple concussions, living in a moldy home, and experiencing neurotoxicity. 

We demonstrated that even if you have been bad to your brain, on the right program you can often reverse the damage and improve your life. It’s one of the most exciting discoveries in medicine today. I hope this message finds anyone who played contact sports like football, hockey, soccer, boxing so they can find help because their degenerative conditions can be reversed.
— Dr. Daniel Amen, MD, psychiatrist and author of Change Your Brain, Change Your Life
Illustration of a brain with a band-aid on it, demonstrating that it is damaged.

Why This Research Study Is So Important

It’s well known that brain injuries are common in professional American football players, and they increase the risk of mild cognitive impairment, dementia, depression and CTE (1-2).

A study sponsored by the National Football League (NFL) found that 6.1% of retired NFL players over the age of 50 had been diagnosed with dementia, which is five times the national average of 1.2%.

Even 2% of players aged 30 to 49 have received a dementia-related diagnosis, which is 20 times higher than the rate of the general population within that age group (3). 

And in a study of 100 active and retired NFL players, researchers found reduced brain blood flow and higher rates of depressionmemory and attention problems compared to the general population (4). 

Brain injuries also increase the risk of drug abuse (5-6). 

Lastly, another study reported that 96% of all former NFL players autopsied had CTE, and that 79% of males who played football at any level also had CTE (10). 

But brain injuries and neurological damage don’t just affect retired professional football players. 

Millions of people, including soldiers, suffer concussions every year.  

In addition, substance abusers also experience high levels of brain damage from drugs and alcohol, and from the increased likelihood of suffering brain injuries during intoxication (7). 

But based on Dr. Amen’s protocol, there is hope. And it’s possible to reverse brain damage.

Below is the protocol that the NFL players followed to reverse brain damage and cognitive impairment, and it significantly improved their brain, mental health and quality of life.

 

1. Improve Your Diet and Exercise Regularly

Even after taking into account their large body frames, forty-eight percent of players in the study were overweight or obese.

So they were encouraged to eat healthier and exercise regularly in order to lose weight. 

This is because obesity is associated with dementia and smaller brain size (8). 

For exercise, you should find an aerobic activity that you enjoy so that you’ll stick with it consistently.

This is exercise routine I try to follow consistently:

Group of people running. Exercise helps reverse brain damage.
  • Lift heavy weights 1-4 times per week

  • High-intensity interval sprinting 1-2 times per week

  • Walk as much as I can (ideally 30-60 minutes every day)

  • Run for 20-30 minutes before lifting weights

If you’re looking for a bunch of healthy, brain-boosting foods that you can eat on a regular basis, check out my Free Grocery Shopping Guide for Optimal Brain Health and my Fuel Your Brain Cookbook.

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2. Eliminate Alcohol

A mug of beer. Alcohol should be avoided if wanting to reverse brain damage since it is a neurotoxin.

Not too surprisingly, the NFL players in Dr. Amen’s study were encouraged to completely eliminate alcohol.  

Alcohol is a neurotoxin and wreaks havoc on the brain by raising cortisol levels, disrupting the blood-brain barrier, and increasing inflammation and oxidative stress (11). 

There are ways to protect your brain from alcohol, but you’re better off avoiding it completely, or significantly reducing your consumption, if you’re trying to heal from brain damage. I personally don’t drink alcohol at all anymore.

Other than alcohol, the NFL players were also told to eliminate others drugs, including cigarettes.  

 

3. Get Enough Sleep

Baby sleeping. Sleeping helps the brain recover and heal and helps reverse brain damage.

Getting enough high-quality sleep was another key aspect of Dr. Amen’s therapeutic protocol for the NFL players because it’s so important for brain health. 

Deep sleep has been shown to slow down cognitive decline, reduce cortisol levels, promote the regeneration of myelin, increase the growth of new brain cells, and support the blood-brain barrier

That’s why getting at least 7 hours of high-quality, restorative sleep is so important.

I used to have very poor quality sleep and it was one of main factors that contributed to my poor mental health.  

This sleep supplement contains magnesium and a number of other natural compounds that I’ve used over the years to improve sleep.

But I work with my clients so that they can naturally maximize the quality of their sleep without so many supplements. We have free online workshop that talks about how you can work with us. You can register for the workshop here.

 

4. Reduce Brain Inflammation with Omega-3 Fatty Acids

A piece of cooked salmon. Salmon contains omega-3 fatty acids which can help the brain heal and recover from damage.

Your brain is made up of about 60% fat, so you want to eat high-quality fats so that it can rebuild itself.

Omega-3s fatty acids are the highest quality fats for the brain, and increasing your intake of them is one of the most impactful ways to reverse brain damage. 

Dr. Amen gave the NFL players 5.6 grams of fish oil each day, containing 1720 mg of EPA and 1160 mg of DHA.

EPA and DHA are omega-3 fatty acids that are necessary for the optimal functioning of your brain and nervous system. They have been shown in many studies to significantly reduce inflammation; improve memory, mood and cognition; and protect against mild cognitive impairment, dementia and Alzheimer's disease (9-10). 

They are also the structural components of synapses, and have been shown to support the brains of people with neurodegenerative diseases who have experienced synaptic loss (12). 

It’s important to get enough omega-3s because they are essential fats that your body cannot produce itself.

They are found primarily in cold water fish such as salmon, black cod, sablefish, sardines and herring.

Unfortunately, most people don't consume enough omega-3 fatty acids through their diet.

That’s why I recommend people supplement with krill oil, a special kind of fish oil that contains the essential omega-3 fatty acids.

I previously wrote about the importance of omega-3 fatty acids in-depth here

Make sure you also check out this article for 22 other effective ways to reduce inflammation in the brain.

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5. Get Enough of These Vitamins and Minerals

Research shows that supplementing with B vitamins, vitamin C and minerals can reduce stress, improve mental health, and increase cognitive performance (13).

So Dr. Amen got the NFL players in the study to take a high-potency multivitamin every day. 

I don’t usually recommend all-in-one multivitamins because they often contain too many synthetic vitamins that we don’t need, and not enough of the minerals that we do need. 

Instead, I regularly take minerals, B vitamins, and this supplement with Vitamin C.

 

6. Enhance Brain Blood Flow

An illustration of a brain and blood flowing throughout it. Blood flow to the brain is essential if you want to reverse brain damage.

Dr. Amen also focused on increasing blood flow in the brains of the retired NFL football players. 

The main way he enhanced brain blood flow was by giving them Ginkgo Biloba.

Ginkgo Biloba is a plant used in China for thousands of years to treat a number of health problems. It’s one of the top-selling herbal supplements in the world, and it’s even a prescription herb in Germany. 

It’s most commonly used to improve brain health, as it’s been shown to increase cognitive function, memory and attention in both healthy and unhealthy individuals. It even reduces the risk of dementia and Alzheimer’s disease and can improve mood and mental energy.

It has these effects primarily by increasing blood flow to the brain (27). 

Ginkgo biloba extract is included in the Optimal brain supplement

Check out this article for 20 other ways to increase blood flow to the brain. 

 

7. Increase Acetylcholine

Illustration of a body.

The retired football players also supplemented with Acetyl-L-Carnitine (ALCAR) and Huperzine A to increase levels of acetylcholine in their brain. 

Acetylcholine is considered the “learning” neurotransmitter and plays a key role in the brain’s cognitive processes. 

Huperzine-A is a compound extracted from the herbs of the Huperziceae family.

It has neuroprotective effects and cognitive enhancing properties because it increases acetylcholine. It does this by inhibiting acetylcholinesterase, an enzyme that breaks down acetylcholine. Because of this, it’s a promising treatment for fighting cognitive decline and Alzheimer's disease (33). 

Acetyl-L-carnitine (ALCAR) is an acetylated form of the amino acid carnitine. It has neuroprotective and cognitive-enhancing effects and helps reverse neurological decline by increasing levels of acetylcholine in the brain and supporting mitochondria function (32). 

It is often used as a brain booster because it increases alertness and provides support to brain cells. It’s also been shown to be very effective at alleviating chronic fatigue and improving mood.

ALCAR can be found in the Optimal Brain supplement

Check out this article for 25 other ways to increase acetylcholine levels in the brain.

And make sure you read this article to learn more about the remarkable benefits of ALCAR.

 

8. Increase Antioxidants

Another key aspect of reversing brain damage is optimizing your intake of antioxidants, and Dr. Amen doesn’t ignore this.

Dr. Amen had the NFL football players in his study take Alpha Lipoic Acid (ALA) and N-Acetyl-Cysteine (NAC) daily. 

NAC is a modified form of the amino acid cysteine, and precursor to glutathione, your body’s master antioxidant

Environmental toxins and oxidative stress deplete your body's reserves of cysteine and glutathione, but supplementing with NAC can increase and normalize cysteine and glutathione levels.

This can combat and reduce oxidative stress in the brain, which helps treat several mental illnesses, including cognitive problems and addiction (23). 

Alpha Lipoic Acid (ALA) is a fatty acid created in the body, playing a role in mitochondrial energy metabolism. In supplement form, it is a potent antioxidant compound that has been shown to reduce oxidative stress and inflammation in the brain, which can contribute to neurological decline. It also helps regulate blood sugar levels, which is crucial for healthy brain function (24-25). 

Several other studies have found that a combination of antioxidants – including NAC, ALA, Vitamin C and Vitamin E can improve cognitive functioning and decrease symptoms of cognitive decline. This is likely because oxidative stress plays a major role in the development of cognitive impairment and dementia, and these antioxidant nutrients and plant compounds can counteract this (14-22). 

NAC, ALA, Vitamin C, Vitamin E and several other antioxidant nutrients are included in the Optimal Antiox supplement.

Antioxidants can also reduce levels of cortisol, your body’s main stress hormone. 

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9. Reduce Cortisol with Phosphatidylserine

Participants in Dr. Amen’s study also supplemented with phosphatidylserine.

Phosphatidylserine is a fat-soluble amino acid that supports cognitive function. 

High amounts of phosphatidylserine can be found within the brain, and supplementation has been shown to improve attention, learning and memory.

…consumption of phosphatidylserine may reduce the risk of dementia and cognitive dysfunction
— Food and Drug Administration

It’s also been shown to reduce cortisol, which can negatively affect the brain at chronically high levels (26). 

I personally take phosphatidylserine every day. It's included in the Optimal Brain supplement

Make sure you read this article to learn more about the remarkable benefits of Phosphatidylserine.

 

10. Optimize Important Health Markers

Picture of blood in blood containers after being drawn.

Important health markers were also monitored and optimized to ensure that the NFL players were in the best health possible to support their brain.

Here are some of the markers Dr. Amen monitored in the NFL players:

Weight measures, such as body mass index and height-to-weight ratio – research shows that as a person's weight goes up, the size of their brain goes down. To reduce this problem, Dr. Amen ran an weight loss class to help the NFL players lose excess weight. 

Fasting blood glucose levels – Having high fasting blood glucose levels increases your risk of developing type 2 diabetes, which is associated with depression and dementia

C-reactive protein – This is a measure of inflammation, which is associated with many chronic illnesses, including depression, dementia and chronic pain. Dr. Amen aims for a measure of less than 1mg/liter. A healthy diet and nutrients can help get inflammation under control. Make sure you read this article for other ways to reduce inflammation.

Vitamin D – Vitamin D is a fat-soluble vitamin that our skin synthesizes when exposed to the sun. Every tissue in your body has vitamin D receptors, including the brain, so a deficiency can lead to costly physiological and psychological consequences, including cognitive impairment. Normal levels are between 30 and 100 ng/mL. Dr. Amen prefers his patients’ levels to be between 50 and 100 because optimal vitamin D levels can reduce inflammation and improve mood. To boost vitamin D levels, he encouraged players to get more sunlight or take a Vitamin D3 supplement. It's important to test and monitor your Vitamin D levels before and after supplementing with it.

Ferritin – Ferritin is a measure of iron stores. Iron deficiency can cause fatigue, but too much iron can cause stress and accelerate aging. If the NFL players’ ferritin levels were too low, Dr. Amen gave them iron. If they were too high, he encouraged them to donate blood. I personally prefer beef liver capsules as good source of iron instead of taking iron supplements. 

In addition to the above strategies, Dr. Amen and his team treated other dementia risk factors, such as hypertension, heart disease, gum disease, alcohol and drug abuse, low thyroid and testosterone levels, sleep apnea, and ideally the cessation of anti-anxiety medications such as benzodiazepines.

Check out this article for several other important blood tests.

 

11. Reduce Homocysteine

Illustration of the homocysteine symbol. Normalizing homocysteine levels can help the brain recover after damage.

This step – and the next two – are not a part of the original study.

However, Dr. Amen says he uses these treatments with his patients, including retired football players.

Homocysteine is an inflammatory compound at high levels, which can lead to the development of mild cognitive impairment, Alzheimer’s disease, depression and other mental health disorders. 

However, certain B vitamins have been shown to normalize homocysteine levels and reduce the rate of cognitive decline.

As a result, Dr. Amen says that he recommends his NFL patients supplement with methyl-B12, methyl-folate, and P-5-P (bioactive B6).

Trimethylglycine (TMG) and S-adenosylmethionine (SAM-e) also lower homocysteine.

I personally prefer SAM-e since it is the most powerful and noticeable.

Here is a full article all about how to lower homocysteine levels. 

You can check your homocysteine levels by ordering this blood test

For those players who were depressed or demented, we did more. I acted as the psychiatrist for a number of our players or a consultant to their own physicians. For many, I prescribed natural antidepressants, such as SAMe, because it also helps with pain.
— Dr. Daniel Amen
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12. Hyperbaric Oxygen Therapy (HBOT)

A number of our players also opted to do hyperbaric oxygen therapy (HBOT), which we have seen improve blood flow to the brain. Over the years I have been impressed with HBOT’s ability to increase blood flow to damaged brains.
— Dr. Daniel Amen
Woman lying in hyperbaric oxygen tank. Male doctor sitting beside her. HBOt helps reverse brain damage.

Again, this wasn’t included in the main protocol of the study, but Dr. Amen often recommends it to NFL players or anyone else with brain damage. 

Hyperbaric oxygen therapy (HBOT) is a treatment that enhances healing in the brain.

Patients inhale 100% oxygen in a total body chamber. 

Usually, oxygen is transported throughout the body only by red blood cells. But with HBOT, oxygen is dissolved into all body fluids, including the fluids of the central nervous system.

This leads to oxygen being  carried to areas of the body where circulation is diminished or blocked. As a result, extra oxygen can reach all damaged tissues, including areas of the brain that need to heal.

Lots of research shows that HBOT improves blood supply to the brain, reduces inflammation, and enhances neurogenesis, which improves recovery after injury to the central nervous system (34-38). 

You’ll need to find a practitioner or clinic in your area that provides this treatment.

HBOT can be expensive though. That's why I decided to buy my own oxygen concentrator. An oxygen concentrator is much less expensive than HBOT but it still helps.

My doctor uses this one at his clinic and recommended it to me. 

But I did a lot of my own research before buying my own and got this one instead. I use it almost every day. It's the best option on the market. You can also get a refurbished one for cheaper.  

Check out my full article about oxygen therapy for more information. 

 

13. Neurofeedback

Brain hooked up to computer. Neurofeedback can help reverse brain damage.

Neurofeedback is a type of biofeedback that shows you your brain activity in real-time and teaches you how to self-regulate it.  

Sensors are placed on your scalp to measure your brain’s activity, and the measurements are displayed using video or sound.

Dr. Amen uses it with his NFL patients.

In our retired NFL players, we often saw excessively high slow wave activity (excessive delta and theta) and too little fast wave activity (too little beta) in the front part of the brain. Many of our athletes thought of neurofeedback like going to the gym for their minds and found it very helpful.
— Dr. Daniel Amen

It’s best to work with a qualified practitioner.

But I also like the Muse headband. It’s a good substitute and gives you real-time feedback in your brainwaves while you meditate. I previously wrote about it here, and you can get it through the Muse website

Please note: If you’re interested in trying neurofeedback, I recommend becoming a client and working with us to determine the best type of neurofeedback for you and your condition. I have found that some types of neurofeedback are completely ineffective and may even be harmful. So it’s very important to do the right type of neurofeedback that actually works. It’s also critical to work with a qualified neurofeedback practitioner who knows what they are doing. Otherwise, you can get worse. We help our clients find a qualified practitioner in their area.

 

Conclusion

Illustration of person holding a blue brain in their hands.

Researchers used to believe that the brain could not heal, but they now know that’s wrong. 

Brain plasticity is possible, and if you put the brain in a healing environment, it can get better, and brain damage can be reversed. 

But the above protocol isn’t just for retired NFL players. 

It also applies directly to the larger traumatic brain injury and drug abuse communities.

Or simply anyone who is experiencing cognitive decline, depression or other mental health problems. 

The retired NFL players in the study had sustained brain injuries decades previously, but they improved. 

If researchers can improve the brains of retired football players – who have had tens of thousands of hits to their heads – imagine the benefit you can get with a brain healthy program.

You don’t have to be held hostage by your bad brain. 

You can recover from brain damage, brain infection, substance abuse and toxic exposure. 

And Dr. Amen isn’t the only doctor showing the brain’s incredible power to heal.

Dr. Dale Bredesen, MD, is reversing cognitive decline and dementia with his own brain rehabilitation program. 

You can read more about his protocol here.

This work is incredibly important for football players, soldiers, firefighters, police, and anyone who has suffered brain trauma and damage.

Please share this post with anyone that you think would benefit from the information within it.

 

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Live Optimally,

Jordan Fallis

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References:

(1) https://www.ncbi.nlm.nih.gov/pubmed/16239884

(2) https://www.ncbi.nlm.nih.gov/pubmed/17545878

(3) http://ns.umich.edu/Releases/2009/Sep09/FinalReport.pdf

(4) http://neuro.psychiatryonline.org/doi/abs/10.1176/jnp.23.1.jnp98

(5) https://www.ncbi.nlm.nih.gov/pubmed/18991956

(6) https://www.ncbi.nlm.nih.gov/pubmed/20414130

(7) https://www.ncbi.nlm.nih.gov/pubmed/19345341

(8) https://www.ncbi.nlm.nih.gov/pubmed/19662657

(9) https://www.ncbi.nlm.nih.gov/pubmed/17574755

(10) http://ftw.usatoday.com/2015/09/researchers-find-evidence-of-cte-in-96-of-deceased-nfl-players-they-tested

(11) https://www.ncbi.nlm.nih.gov/pubmed/17241155

(12) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2344157/

(13) https://www.ncbi.nlm.nih.gov/pubmed/20454891

(14) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984445/

(15) https://www.ncbi.nlm.nih.gov/pubmed/14500988

(16) https://www.ncbi.nlm.nih.gov/pubmed/9110909/

(17) https://www.ncbi.nlm.nih.gov/pubmed/10681271/

(18) https://www.ncbi.nlm.nih.gov/pubmed/16402761

(19) https://www.ncbi.nlm.nih.gov/pubmed/18042001

(20) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC161361/

(21) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675154/

(22) https://www.ncbi.nlm.nih.gov/pubmed/17510979/

(23) https://www.ncbi.nlm.nih.gov/pubmed/18990082

(24) https://examine.com/supplements/alpha-lipoic-acid/

(25) https://www.ncbi.nlm.nih.gov/m/pubmed/20622459/

(26) https://www.ncbi.nlm.nih.gov/pubmed/2170852

(27) https://www.ncbi.nlm.nih.gov/pubmed/12905098

(28) https://examine.com/supplements/vinpocetine/

(29) https://www.ncbi.nlm.nih.gov/pubmed/15760651

(30) https://www.ncbi.nlm.nih.gov/pubmed/12498034

(31) https://www.ncbi.nlm.nih.gov/pubmed/12460136

(32) https://www.ncbi.nlm.nih.gov/pubmed/19720082

(33) https://www.ncbi.nlm.nih.gov/pubmed/17657601

(34) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231808/

(35) https://www.ncbi.nlm.nih.gov/pubmed/20715898

(36) https://www.ncbi.nlm.nih.gov/pubmed/22146131

(37) https://www.hindawi.com/journals/mi/2013/512978/

(38) http://stroke.ahajournals.org/content/45/6/1807

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28 Proven Ways to Promote the Regeneration of Myelin

This article was originally published in 2017 and has been regularly updated to reflect new research

Myelin is critical for optimal brain function and mental health.

What is myelin?

Myelin sheath.

Myelin is a fatty, white substance that wraps around the end of many nerve cells. It forms an electrically insulating sheath that increases nerve condition speeds.

In other words, it allows your brain to send information faster and more efficiently, making it absolutely essential for the optimal functioning of your nervous system (39, 40). 

So not surprisingly, myelin sheath plays a key role in determining intelligence and improving cognitive performance (41, 42). 

The production of myelin throughout the nervous system is called myelination or myelinogenesis.

But demyelination can also happen. 

This happens when the myelin that insulates your nerves is destroyed or deteriorates, leading to mental health symptoms and neurodegenerative diseases (44). 

Multiple sclerosis is one of the more common demyelinating condition, but a number of neurological and psychiatric illnesses have been linked to demyelination, including (45):

Myelin sheath.

If you have one of these conditions and suspect you might have symptoms of demyelination, don’t worry.

There are dietary and lifestyle modifications that can help your body repair and re-manufacture myelin. Studies show that oligodendrocyte cells are responsible for the formation of new myelin in both the injured and normal adult brains (43).

Here are 28 holistic ways to increase oligodendrocyte cells, promote myelin production and myelin sheath repair, and increase the regeneration of myelin. 

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1. Deep Sleep and Melatonin

Research has found that sleep increases myelination and increases the production of oligodendrocyte precursor cells (OPCs).

One study found that production of OPCs doubled in mice while they slept. The mice that were forced to stay awake had higher levels of stress hormones and higher rates of brain cell death (1-2). 

Researchers believe this means that sleep loss can aggravate symptoms of multiple sclerosis.

Baby sleeping. Sleep and melatonin help regenerate myelin.

That’s why getting at least 7 hours of high-quality, restorative sleep is so critical. 

But it’s not just the amount of sleep you get that’s important. It’s also the quality of your sleep. 

The researchers found that the production of the myelin-forming cells increased the most during deep, rapid-eye movement (REM) sleep. 

Melatonin, your body’s sleep hormone, has also been shown to promote myelination and increase myelin production by significantly reducing inflammation in the brain (46).

This supplement contains magnesium and a number of other natural compounds that I’ve used over the years to promote the production of melatonin.

But I work with my clients so that they can naturally produce more melatonin and maximize the quality of their sleep without so many supplements. We have free online workshop that talks about how you can work with us. You can register for the workshop here.

Deep sleep can also improve your brain’s growth hormone, lower your stress hormone, and slow down the onset of dementia

 

2. Iodine and Thyroid Hormones

Iodine is a key mineral that is required to produce thyroid hormones. Without enough iodine, you may end up with symptoms of hypothyroidism

Research shows that a deficiency in iodine and lack of thyroid hormones can impair myelination (7).

The process of myelination is known to depend on the thyroid hormone. The myelinating cells are the oligodendroglia which appear to stop functioning in MS (and sometimes to a milder degree in Alzheimer’s disease, and other conditions). The cells’ absorption of thyroid hormone is influenced by dietary factors.
— Ray Peat

Other studies show that thyroid hormones stimulate the expression of myelin protein genes, and promote remyelination in the brain by enhancing oligodendrocyte maturation (8, 9). 

So supporting your thyroid and getting enough iodine are key steps towards increasing myelin and optimizing the formation of new myelin. 

You can read more about how to support your thyroid and enhance the production of thyroid hormones here.  

I highly recommend getting a full thyroid panel done regularly.

 

3. Vitamin C

Oranges. The Vitamin C in oranges help regenerate myelin.

Vitamin C is known to participate in myelin formation (10, 11). 

Collagen synthesis, which is dependent on Vitamin C, has also been linked to the formation of myelin sheath (12, 13). 

Vitamin C can be found in foods such as peppers, citrus fruits, green leafy vegetables, broccoli, tomatoes, and berries. These foods are included in my Free Grocery Shopping Guide for Optimal Brain and Mental Health.

You can also take it in supplement form
 

 

4. Zinc

As I’ve discussed before, zinc is an essential trace mineral that activates several hundred enzymatic reactions, including neurotransmission.

It’s estimated that 2 billion people in the world are deficient in zinc, and six different studies show that subclinical deficiency of zinc impairs brain function in children and adults (14-16).

Oysters. The zinc in oysters help regenerate myelin.

So, if you struggle with a brain or mental health disorder, it’s quite possible that you’re deficient.  

Zinc also affects myelination.

The mineral is needed for myelin proteins to work properly, and research shows that a deficiency in zinc leads to a reduction in myelin formation and myelin recovery (17). 

Some of the best food sources of zinc include oysters, grass-fed beef, pumpkin seeds, cashews, mushrooms and spinach. These foods are included in my Free Grocery Shopping Guide for Optimal Brain and Mental Health.

But I still recommend at least short-term supplementation to ensure you get enough to increase myelination.

That’s why I created the Optimal Zinc supplement

Check out my previous post about zinc and copper if you’re interested in discovering more steps you can take to increase your zinc levels.  

 

5. Cholesterol

Cholesterol is a waxy, fat-like substance that’s found in all cells of the body.

Your body needs cholesterol to make hormones and vitamin D.

And it’s an indispensable component of myelin. 

Butter. The cholesterol in butter helps regenerate myelin.

Without it, myelin membrane growth is “severely perturbed” (18). 

So just like you shouldn’t be afraid of saturated fat, you shouldn’t be afraid of eating cholesterol-rich foods.

Some of the best sources of cholesterol include grass-fed butter or ghee, beef liver and pastured egg yolks. These foods are included in my Free Grocery Shopping Guide for Optimal Brain and Mental Health.

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6. Lithium 

Lithium is predominantly known as a medication given to bipolar patients to manage their symptoms. 

However, it’s also an essential mineral.

Bipolar patients are often given high doses of lithium carbonate.

But low doses of lithium orotate can be safely supplemented to support the brain and improve mental health.

Research shows that lithium stimulates the expression of myelin genes, restores the myelin structure, and promotes remyelination (19). 

As I discussed before, lithium orotate can also increase your brain’s growth hormone (BDNF)

So it’s definitely something you want to consider taking if you want to increase myelin in the brain.

 

7. Oxygen Therapy

Hyperbaric oxygen therapy (HBOT) is a treatment that enhances healing and recovery after injury to the central nervous system.

Patients inhale 100% oxygen in a total body chamber. 

Usually, oxygen is transported throughout the body only by red blood cells. But with HBOT, oxygen is dissolved into all body fluids, including the fluids of the central nervous system.

This leads to oxygen being  carried to areas of the body where circulation is diminished or blocked. As a result, extra oxygen can reach all damaged tissues, including areas that need to heal.

Researchers have found that HBOT can cause "significant remyelination" (83-84). 

Other studies show that it can alleviate myelin damage (85). 

You’ll need to find a practitioner or clinic in your area that provides this treatment.

 

8. Ketogenic Dieting

A ketogenic diet is a very low-carb diet – less than 50 grams of carbs per day.

When you restrict carbohydrate-rich foods – such as grains, sugar, and even potatoes, legumes and fruit – your body enters ketosis, a metabolic state in which your body and brain run on fatty acids and “ketones” instead of glucose.

Foods incorporated in a ketogenic diet. A ketogenic diet and ketones can help repair myelin.

Ketones are an alternative source of energy for your brain cells. And several studies show that when you increase the production of ketones, you improve myelination and increase myelin production (3-6). 

So if you’re trying to rebuild myelin sheath, you should consider a cyclic ketogenic diet. 

As I’ve discussed before, ketones can also increase your brain’s growth hormone, help you overcome brain fog, support your brain’s mitochondria, and slow down cognitive decline

 

9. Iron

Iron is an essential mineral that is present in all cells and plays a role in several vital functions, including oxygen consumption and ATP production.

It’s also important for myelin production.

Studies show that low iron levels lead to a reduction in myelination, and normal iron levels support the formation of myelin and increase myelin (20). 

Beef liver is one of the best sources of iron, and it’s included in my Free Grocery Shopping Guide for Optimal Brain and Mental Health.
 

 

10. Low Level Laser Therapy

Low-level laser therapy (LLLT), or photobiomodulation, is a treatment that uses low-level (low-power) lasers or light-emitting diodes (LEDs) to stimulate brain cells, helping them function better.

Most doctors don't know about LLLT; but not every doctor.

Dr. Norman Doidge, a physician who teaches at the University of Toronto here in Canada, discusses the amazing effects of LLLT in his book The Brain’s Way of Healing.

Researchers have found that LLLT can increase myelination and increase the total number of myelinated axons (79-81). 

LLLT has also been shown to restore normal levels of myelin in animals (81-82). 

I previously wrote about my experience with low-level laser therapy here.

You can use this device and shine the red and infrared light on your forehead for 5 minutes every day. I also shine it on other parts of my head and on my entire body, including on my thyroid, thymus gland and gut. I have experienced incredible benefits from doing this.

Alternatively, you can use this smaller and more convenient device and shine it on your forehead.

You can also use the Vielight Neuro Duo, which is a transcranial-intranasal headset with 810 nm of near infrared light. It penetrates deeper into brain tissue and is absorbed better by the central nervous system. If you decide to try a Vielight device, you can use the coupon code JORDANFALLIS for a 10% discount

LLLT also supports mitochondria function, reduces brain fog, promotes synaptogenesis, and increases blood flow to the brain

I encourage you to check out my full article about it for more information.

 

11. Phosphatidylserine

Phosphatidylserine is a fat-soluble amino acid compound that plays a key role in optimal cognitive function. High amounts of phosphatidylserine can be found within the brain, and supplementation has been shown to improve attention and memory, especially in the elderly (21-23).

…consumption of phosphatidylserine may reduce the risk of dementia and cognitive dysfunction in the elderly.
— Food and Drug Administration

Researchers have also concluded that phosphatidylserine is required for healthy nerve cell membranes and myelin in the brain (24). 

That’s why phosphatidylserine is part of the Optimal Brain supplement

Make sure you read this article to learn more about the remarkable benefits of Phosphatidylserine.

 

12. Pregnenolone

Pregnenolone is a steroidal hormone manufactured by the body, but it can also be taken as a supplement.

Picture of a human brain.

It’s been shown to enhance memory and reduce stress-induced fatigue.

It’s the precursor to almost all other steroid hormones, including DHEA, progesterone, testosterone, estrogens, and cortisol.

Pregnenolone and other steroid hormones regulate, repair, rebuild, and increase the production of myelin (25-28). 

I personally tried pregnenolone. It did give me a boost in brain function and mental energy. However, it also made me angry and irritable so I stopped taking it. This happens to some people, but a lot of people don't experience this. It's worth trying to see how you react.

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13. Uridine 

Uridine is a nucleotide base found in beer.

I don’t recommend drinking beer, but supplementing with pure uridine can protect the brain, enhance cognition, and increase mood and motivation. 

It’s been proven to help treat “myelin sheath lesion” in several experimental and clinical studies (29, 30). 

 

14. Herbs That Increase Myelin

Ashwagandha helps regenerate myelin.

Ashwagandha is a popular Indian herb commonly used to prevent anxiety.

Withanoside IV is one of the main therapeutic compounds in ashwagandha and research shows that it can increase myelin levels in the nervous system (31).

I have taken ashwagandha during periods of high stress. It’s included in this supplement.

Ginkgo Biloba is another common herb, which is taken for cognitive enhancement or to alleviate cognitive decline.

It’s beneficial effects of cognition may be because it significantly increases the number of myelinated axons (34).  

Ginkgo Biloba is included in the Optimal Brain supplement

 

15. Inositol

Inositol is a small molecule structurally similar to glucose that is involved in cellular signalling. 

At high doses, it reduces anxiety. 

Research shows that animals treated with inositol have significantly fewer demyelinating lesions (32). 

I took high doses of inositol powder when weening off psychiatric medication.

I previously wrote a full article about inositol here

 

16. Lion’s Mane 

Lion’s mane mushroom helps regenerate myelin.

Hericium Erinaceus – better known as Lion’s mane mushroom – might be my favourite way to regenerate myelin. 

Research shows that lion’s mane increases the rate of myelination production, and the process of myelination begins earlier in the presence of the mushroom (33). 

I used to take this lion’s mane mushroom. It’s one of the highest-quality lion’s mane mushroom supplements that I could find from a reputable brand. I spent a lot of time researching and looking into different sources because not all lion's mane supplements are high-quality and effective, and I settled on this one.

 

17. Consume Flavonoids

There are several flavonoids, a diverse group of phytonutrients found in fruits and vegetables, that have been demonstrated to promote myelination. 

Research shows that the flavonoids luteolin, quercetin and fisetin significantly decrease myelin phagocytosis and may be able to limit the demyelination process during multiple sclerosis (35). 

Quercetin, one plant flavonoid in particular with potent antioxidant action, has been shown to increase the number of oligodendrocyte precursor cells and myelin basic protein cells (36). 

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18. Learn or Experience Something New

You can also generate new myelin by learning something new and exposing yourself to novel life experiences.

Guitar. Learning the guitar can help you form new myelin.

For example, one report showed that learning a new instrument leads to increased myelin in areas of the brain involved with musical performance. 

The researchers explain that myelin increased proportionately to the number of hours each person had practiced the instrument (38).

So the more you practice and try to learn something, the more myelin you generate.

 

19. Exercise

I’ve already discussed how exercise increases your brain’s growth hormone, supports your brain’s mitochondria, helps reverse cognitive decline, and stimulates your vagus nerve.

It clearly does so much good, so it’s not too surprising that it also supports myelin formation. 

Woman lifting weights. Exercise can help with the regeneration of myelin.

Research shows that long-term exercise improves memory by increasing and restoring myelin (47). 

Running has also been shown to increase myelination and delay the progression of demyelination, and therefore delays the progression of Alzheimer’s disease (48). 

Lastly, researchers have found that exercise increases mitochondrial activity, which then increases myelination in the brain (49). 

This is exercise routine I try to follow consistently:

  • Lift heavy weights 1-4 times per week

  • High-intensity interval sprinting 1-2 times per week

  • Walk as much as I can (ideally 30-60 minutes every day)

  • Walking, weightlifting and sprinting are the best forms of exercise, but you should choose a sport or exercise routine that you enjoy, so that you’ll stick with it consistently

 

20. Brain-Derived Neurotrophic Factor (BDNF)

Brain-derived neurotrophic factor, also known as BDNF, is a naturally-occurring hormone in the brain that improves brain function and lowers your risk of mental disease. 

It also regulates the myelination process. 

Research shows that BDNF produces a long-term increase in both the rate and extent of myelination, and enhances and accelerates myelin formation (50). 

I previously provided 31 ways to boost BDNF in this post.  

 

21. Testosterone

When I lived in a moldy home, suffered multiple concussions and was placed on antidepressants, my testosterone plummeted. 

Very muscular man looking angry. Testosterone can increase myelin formation.

No conventional doctor tested my testosterone because they assumed every a man in his 20s would have healthy levels. 

But they were wrong. 

Eventually I saw a smart doctor and he found out that I had the testosterone levels of an old man.

I was put on testosterone replacement therapy for almost one year to get my levels back to normal. And over that time, I saw a huge increase in my brain and mental health.

This may be because testosterone has been shown to stimulate the formation of new myelin and reverse myelin damage (51). 

Researchers have also concluded that hormone replacement should be a considered treatment for males who have multiple sclerosis, as it can stall (and perhaps even reverse) the neurodegeneration associated with MS (52). 

That's why it's so important to test. Make sure you check both total testosterone and free testosterone

You can test your total and free levels here. 

 

22. Omega-3 Fatty Acids

Omega-3 fatty acids are essential fats that your body cannot produce itself. They are found primarily in fish and are necessary for the normal electrical functioning of your brain and nervous system.

Cooked piece of salmon. The omega-3 fatty acids in salmon can help with the regeneration of myelin.

They appear in most of my posts because they are so critical for brain and mental health and affect so many aspects of wellness.

They’ve been shown to help people overcome addiction, repair the blood-brain barrier, stimulate the vagus nerve, and even reverse cognitive decline.

And now researchers have found that they also increase myelin production, helping your body produce more myelin (53, 54). 

According to Judy Graham, author of the book Managing Multiple Sclerosis Naturally: A Self-Help Guide to Living with MS, myelin cell membranes that contain omega-3 fatty acids are more fluid, which improves the efficiency of nerve impulse conduction. 

She also points out in her book that rates of multiple sclerosis are lower in areas of high fish consumption. 

I eat lots of wild salmon and sometimes supplement with krill oil.

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23. Vitamin D and Vitamin K2

Vitamin D is a fat-soluble vitamin that our skin synthesizes when exposed to the sun.

Sun shining through the clouds. Vitamin D from the sun can help repair myelin.

Research shows that the Vitamin D receptor boosts the regeneration of myelin (55). 

Vitamin D also significantly increases myelination in rats (56). 

It’s best to get your Vitamin D from sunlight, but most people can’t get enough, especially during the winter. 

That’s why I sometimes take a Vitamin D3 supplement.

If you decide to supplement, it’s a good idea to also take some Vitamin K2 with it, as it has also been shown to support myelin (57). 

I also highly recommend checking your Vitamin D levels. It's one of the most important tests you can take for your health.

 

24. Choline

Choline is an essential B vitamin that most people don’t consume enough of, because very few foods in the Western diet contain it.

It’s also a component of myelin and supports myelin production.

Egg yolk. Egg yolks contain choline, which can help repair myelin.

Research shows that the choline pathway promotes remyelination, and enhances the repairing and rebuilding of myelin sheath (64). 

Citicoline (also known as CDP-Choline) is the most bioavailable form of choline. 

One study found that citicoline enhances myelin regeneration and increases remyelination in the central nervous system. The researchers concluded that citicoline could become a promising substance for patients with multiple sclerosis because of its regenerative action combined with its excellent safety profile (63). 

That’s why I recommend supplementing with it. It’s one of my favourite supplements for optimal brain and mental health. I find it improves my focus and mental energy. It's included in the Optimal Brain supplement

You can also find some choline in beef liver and egg yolks, but citicoline is more impactful. 

And as I’ve discussed before, citicoline can also help you overcome brain fog and support the blood brain-barrier.

Make sure you read this article to learn more about the remarkable benefits of Citicoline.

 

25. Reduce Inflammation 

Reducing inflammation throughout your entire body is a key step towards protecting and regenerating myelin. 

Man experiencing inflammation in the brain. Reducing inflammation can increase myelin formation.

Researchers have found that inflammatory cytokines reduce myelination, and high levels of inflammation are often found in people with multiple sclerosis (65). 

One of the best ways to reduce inflammation is by following an anti-inflammatory diet.

If you decide to follow an anti-inflammatory idet, you should strive to eliminate all gluten, refined carbohydrates (particularly flour), and processed food from your diet, and increase your intake of vegetables, fruits, wild fish, grass-fed beef and pastured chicken.

My free Grocery Shopping Guide for Optimal Brain Health contains a bunch of healthy anti-inflammatory foods that you can eat on a regular basis. 

Taking curcumin and krill oil supplements can also significantly reduce inflammation in the body and brain. 

Make sure you also check out this article for 23 effective ways to reduce inflammation in the brain.

 

26. B Vitamins and Methylation

A number of different B vitamins can increase myelin and help your body regenerate myelin. 

Vitamin B12 plays a key role in the generation and function of myelin.

Researchers have found that low vitamin B12 levels are significantly associated with myelin degeneration (66, 68). 

Other studies have also shown that people with multiple sclerosis often have abnormally low levels of vitamin B12, and vitamin B12 injections significantly improve their symptoms (67). 

The B Vitamins, including B1, B2, B5, B6 and B12. B Vitamins can help the body form new myelin sheath.

According to Dr. Perlmutter, author of Brain Maker and Grain Brain, vitamin B12 deficiency enhances the destruction of myelin and compromises the ability of the body to repair and rebuild damaged myelin sheath. 

Folate is another B vitamin that plays an important role in the maintenance of myelin. Studies have shown that a deficiency can lead to reduced levels of myelin (69-70). 

S-adenosylmethionine (SAMe) isn’t a B vitamin, but along with folate and B12, it is involved with methylation, and has been shown to increase the development of myelin (71). 

One amazing study found that biotin (Vitamin B7) activates enzymes involved in myelin synthesis and 91% of patients with multiple sclerosis improved with high doses of biotin. Two multi-centric double-blind placebo-controlled trials are currently underway (72). 

Lastly, pantothenic acid (Vitamin B5) can indirectly help with myelin formation because it helps with the synthesis of fatty acids and myelin is mostly made up of fat. Myelin has been shown to degenerate in chickens that are deficient in B5 (73). 

 

27. Probiotics and Prebiotics

It is estimated that 100 trillion bacteria, and 500 to 1,000 species of bacteria, live in the human gut.

These gut bacteria, collectively known as the gut microbiome, help with digestion.

But an increasing amount of research suggests that gut bacteriaalso communicate with your brain through the microbiome-gut-brain axis.

And probiotics and prebiotics can improve your brain health and support myelin production by actually changing the mixture of bacteria in your gut.

Probiotics are live microorganisms with health benefits when consumed, generally by improving or restoring the gut microbiome.

Meanwhile, prebiotics are substances that humans can't digest, so they pass through our gastrointestinal tract and promote the growth of many different strains of good bacteria in your gut. Essentially, prebiotics are food for the probiotics in your intestines.

Research has found that your gut microbes affect the structure and function of the brain by regulating myelination. Probiotics and prebiotics can help upregulate the genes linked to myelination and myelin plasticity (86).

Prebiotic-rich foods include sweet potatoes, carrots, onions, asparagus and squash. These foods are included in my free grocery shopping guide and you should try to eat them as much as possible.

To increase probiotic intake, you can take Optimal Biotics, which is a premium probiotic supplement that improves mental health.

I also like to drink kombucha and eat fermented foods regularly.

Check out this article to learn more about probiotics and prebiotics, and how you can use them to improve your brain function.

 

28. Reduce Exposure to Electromagnetic Fields (EMFs)

“I have no doubt in my mind that, at the present time, the greatest polluting element in the Earth’s environment is the proliferation of electromagnetic fields.” - Dr. Robert Becker, Nobel Prize nominee and author of The Body Electric: Electromagnetism And The Foundation Of Life

You won't hear many people talk about this but it needs to be acknowledged.

An increasing amount of research is showing that electromagnetic frequencies emitted from Wi-Fi, laptops, and cellphones can negatively affect the brain and produce widespread neuropsychiatric effects including depression (59). 

It’s an inconvenient truth that needs to be talked about, rather than downplayed, ignored and dismissed.

Image of EMFs surrounding a home. EMFs can reduce myelin formation, so you are best to avoid them or limit your exposure to them.

Some people are more sensitive to them than others. I’m one of them. 

Two environmental doctors told me that I’m sensitive to environmental radiation, and some of my symptoms can be traced back to EMF hypersensitivity. It's likely why I benefited so much from neurofeedback, as EMFs can affect brainwaves (74-78). 

I suspect a lot of people are dealing with the same problem. 

This research paper explains that there is an association between EMF exposure and myelin deterioration, which may account for many of the symptoms that people with EMF hypersensitivity experience (58).

So if you’re trying to rebuild myelin, it’s a good idea to limit your exposure to EMFs.

How do you that?

Here are some initial steps you can take:

  • Get an EMF meter to determine your exposure. I use this one. It's the best option that is currently available. It measures electric, magnetic and radiofrequency fields. It's like having three meters in one.

  • Put your phone on airplane mode when you’re not using it. Or use a radiation-blocking phone case such as Safe Sleeve. I did a lot of research into radiation-blocking cases and Safe Sleeve is the best on the market. They are manufactured with materials that have been 3rd-party tested to block 99.9% of radiation coming off a cell phone.

  • Turn off Wi-Fi at night while you’re sleeping.

  • If you have a laptop, don’t touch it. Use a wired keyboard and wired mouse instead.

  • Supplement with the herb Rhodiola. It has radioprotective effects (60-62).

This is just the tip of the iceberg. There are many other steps you can take, and I plan on writing more about this soon because it isn’t discussed enough.

This may seem like “woo-woo” but it’s a real issue. And I suspect it will eventually become one of the biggest issues of our time.

 

Conclusion

You don’t have to let your brain deteriorate over time. 

You have the power to maintain it and rebuild the myelin within it. 

Overall, the above 28 steps can help your body regenerate myelin. They have really helped me.

I hope you implement some of them into your daily life and you notice your brain functions more optimally. 

 

Enjoy This Article? You Might Also Like My FREE Food Guide for Optimal Brain Health!

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Live Optimally,

Jordan Fallis

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How to Protect Your Brain from Blue Light

Overcoming brain and mental health issues isn't just about nutrition and supplementation. 

It's also about light.

A woman staring at a screen and being exposed to blue light at night. She is wearing glasses, but they don’t look like they block out the light!

Chronic exposure to artificial blue light is a risk factor that is often overlooked. 

This post talks about how you should be striving to reduce your blue light exposure as much as possible throughout the entire day (unless it’s naturally coming from the sun). 

We're getting way too much blue light nowadays, and it’s taking a toll on your brain and mental health. 

And if you’re interested in learning more about light, I recommend the book Light: Medicine of the Future by Dr. Jacob Liberman. 

 

What Is Blue Light?

Light is part of the electromagnetic spectrum. 

Our eyes can only see light that falls within a small range of the electromagnetic spectrum, called "visible light". The human eye is not capable of "seeing" radiation with wavelengths outside the visible spectrum. 

Visible light corresponds to a wavelength range of approximately 400 to 700 nanometers (nm). Each visible wavelength is represented by a colour. Blue light is defined as having a wavelength between 450 and 495 nm. This short wavelength means that blue light is a type of high-energy visible light (25). 

Blue light is emitted from energy-efficient fluorescent and LED bulbs, and electronics such as computers, smartphones, tablets, and televisions. Obviously, these indoor man-made sources of blue light are on the rise, and we’re being exposed to more blue light in our environments than ever before (26). 

 

Why Artificial Blue Light Is Bad for Your Brain and Mental Health

I’ve been learning more and more that it’s best to limit your exposure to artificial blue light all day long, and not just at night. 

It’s important to note that there’s a big difference between artificial blue light and natural blue light from the sun. 

A lamp emitting blue light.

During the day, exposure to full-spectrum sunlight – which naturally contains some blue light –is actually beneficial and necessary for resetting your circadian rhythm.

The blue light from the sun is also balanced with other colours of light, such as red, green, infrared, and ultraviolet light.

But our devices and artificial lights have five times the amount of blue light than you would get from the sun. 

In the past, our ancestors would have been exposed to blue light from the sun only, and they weren’t exposed to blue light at night. 

But today, we shield ourselves from full-spectrum natural sunlight, and live indoors with excess artificial blue lighting all day long. 

And this is having brain and mental health consequences.

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What The Experts Are Saying

An increasing number of researchers, doctors and health organizations are speaking out about this. 

Dr. Jack Kruse, MD, a neurosurgeon and author of the book Epi-Paleo Rx, and speaks passionately about the risks of blue light. He argues that attending to your light environment is more important than food. 

Dr. Alexander Wunsch, another physician and researcher in the field of photobiology, explains that artificial LED lights have an excess of blue light, and not enough red light, and this creates reactive oxygen species (19):

We don’t have this kind of light quality in nature. This has consequences. The stress has consequences in the retina; it has consequences in our endocrine system.
— Dr. Alexander Wunsch

Even the American Medical Association is speaking out about this issue.  Last June, they released guidelines on how to reduce the harmful human and environmental effects of high-intensity LED lighting.

They point out that the energy-efficient LED lighting adversely suppresses melatonin at night, has a “five times greater impact” on sleep rhythms than conventional lighting, and widespread implementation of this lighting will lead to sleep problems and other conditions related to poor sleep.

Despite the energy efficiency benefits, some LED lights are harmful.
— Dr. Maya A. Babu, AMA Board Member

There is lots of research to support these claims and concerns. 

Researchers have discovered photoreceptors (light-sensitive cells) in our eyes that track the amount of blue light we're exposed to throughout the day. These photoreceptors communicate with areas of your brain that affect your mood, emotions and circadian rhythm (20-22). 

It’s also well-established that blue light at night sends a signal to your body that it’s daytime, which increases the amount of time it takes to fall asleep and reduces the quality of your sleep. It does this by significantly suppressing the production of melatonin, your body’s sleep hormone (27-34).

Melatonin is also an antioxidant that protects your brain and increases mitochondrial function. So chronically low melatonin can lead to lower mental energy and neurodegeneration (35-37). 

In my experience, if your circadian rhythm is thrown off and you’re not sleeping well, it's very hard to be completely healthy and emotionally balanced.

Studies show that exposure to blue light at night is significantly associated with depression (23). 

Other research has found that “higher nighttime light intensity” leads to lower melatonin levels, which contributes to depression and cognitive impairment (24). 

But luckily there are ways to protect yourself.

Let’s get into what you can do to shield yourself from the negative effects of artificial blue light. 

 

1. Use Software That Blocks Blue Light

Installing software that prevents blue light from being emitted from your technology is another cheap and straightforward action you can take to protect yourself from excess blue light.

My number one recommendation is to install the program Iris on your computer. You can download it here

Iris automatically alters the colour temperature of your screen as the day goes on, removing the blue wavelengths after sunset.

The standard setting only removes blue light in the evening, but you can change the settings so that it blocks out blue light all day long. That’s what I do now. 

Iris takes care of your computer, but what about your phone? 

Last year, Apple released Night Shift with its iOS 9.3 update to reduce the amount of blue light emitted from the iPhone. You can learn how to activate this on your iPhone here. I have Night Shift turned on all throughout the day. 

You can also install Twilight if you have an Android device.

 

2. Wear Blue-Light-Blocking Glasses

It's becoming increasing clear that one of the simplest and least expensive ways to support your brain, promote healthy sleep, and lower your risk of chronic mental disease, is to wear blue-light-blocking glasses not just at night, but anytime you are exposed to artificial lighting.

I own multiple pairs of blue-light-blocking glasses myself.  

Research shows that wearing blue-light-blocking glasses improves sleep quality and mood (1). 

Other studies show that wearing blue-light-blocking glasses in a bright room or while using blue-lit technology maintains normal melatonin levels at night (2-4). 

Researchers have also found dramatic improvements in insomnia and mood in about half of bipolar patients who wore blue-blocking glasses (5). 

People with bipolar disorder who wore blue-blocking glasses from 6 p.m. to 8 a.m. for seven days had significant improvements in symptoms of mania compared to those who wore clear glasses. These benefits kicked in after just 3 days (6-7). 

I used to work on a computer in an office with lots of artificial fluorescent lighting shining down on me. 

At that time, I would wear these Gunnar computer glasses. These glasses have a light-yellow tint and are somewhat stylish. They significantly reduced the amount of blue light that I was exposed to throughout the day, which reduced fatigue and eye strain. 

They are like the opposite of sunglasses - I wore them inside when I was exposed to artificial blue light, and took them off when I went outside.

Gunnar Optiks has a wide-range of computer and gaming glasses to choose from through Amazon

If you work under blue light all day, it’s also a good idea to wear long sleeves because your skin also absorbs the blue light. Shielding it from your eyes is the priority though.

At home in the evening, I wear these orange-tinted Uvex glasses as soon as it’s dark outside. They eliminate all blue light, but aren’t stylish at all, so you’re better off wearing them inside and not out in public.

I also just ordered these red glasses, as they block out both blue and green light. Green light has been shown to stunt the release of melatonin, but not nearly as much as blue light. If you don’t have blue-blocking glasses yet, get the red ones

You can also get BluTech prescription lenses for the daytime but I haven’t done that for myself yet.

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3. Increase Your Exposure to Red and Infrared Light

Blue light causes reactive oxygen species in your tissue, and this stress needs to be balanced with near-infrared light that is not present in LEDs.
— Dr. Alexander Wunsch

If you’re exposed to too much blue light, you need to make up for it later by exposing yourself to more red light.

One of the reasons red and infrared light supports brain and mental health is because it combats the effects of blue light. 

Ideally, we would simply be exposed to the sunlight throughout the day, which has a healthy balance of both blue and red light.

But unfortunately, we live in the modern world, and it’s not possible to live outside all day like our ancestors, even though our bodies still expect us to. 

I work in an office environment with lots of blue light, and no red and infrared light.

So to balance out my excess blue light exposure during the day, I use a number of different LED devices and bulbs in the evening that emit red and infrared light. 

As I’ve discussed before, I use this device on my head and thyroid. It has LEDs that emit red and infrared light. 

But what I haven’t mentioned before is that I also have this infrared bulb shining in my bedroom and this red bulb in my bathroom. I use them to light up my apartment, particularly at night.

Infrared saunas are another excellent way to expose yourself to infrared light. Check out my post about the benefits here

Penetrating red light is possibly the fundamental anti-stress factor for all organisms. Old observations such as Warburg’s, that visible light can restore the activity of respiratory pigments, showed without doubt that visible light is biochemically active. By the 1960s, several studies had been published showing the inhibition of respiratory enzymes by blue light, and their activation by red light. The problem to be explained is why the science culture simply couldn’t accept crucial facts of that sort.
— Dr. Raymond Peat

I find that doing all of this increases my energy and mood.

This may all seem strange but it works, and there is plenty of evidence to support it. 

In fact, red light therapy has been around for over 100 years. In 1910, Dr. John Kellogg published a book, titled Light Therapeutics, in which he recommended light therapy for a number of different diseases, including chronic fatigue.

Research shows that high-intensity blue light is bad for your mitochondria, while red light enhances mitochondrial function (15-18). 

I even found a study that clearly shows that red LED light protects animals from fake artificial blue light (14). 

And here is a spreadsheet that compiles a lot of the research showing that red and infrared light can help treat many different diseases, including depression, anxiety, traumatic brain injury, stroke, Parkinson's disease, Alzheimer's disease, multiple sclerosis, hypothyroidism, acne and chronic pain. 

Overall, blue light triggers oxidative stress in your cells, while red light repairs and regenerates your cells. Blue light is the equivalent to eating junk food, while red light is like eating healthy food. Staring at your smartphone all day and night is like eating McDonalds, while shining red light on yourself is like eating more vegetables. If you eat too much junk food, you might make up for it later by eating healthier and exercising. But with blue light, you need to make up for it by absorbing more red light. That’s what I do, and I hope it helps you too. 

 

4. Sleep in a pitch black room

Making sure your bedroom is as dark as possible while you sleep is another step you can take.  

Light can penetrate your eyelids, so simply closing your eyes is not enough. 

A sleep mask.

Even small amounts of light can reduce your melatonin production and disrupt your circadian rhythm. Exposure to room light during sleep has been shown to suppress melatonin by more than 50 percent (8). 

I completely black out my room with black-out curtains.

Another option is to wear a sleep mask. 

However, it’s important to note that your skin also has photreceptors and can sense light in your environment (9-11). 

So it’s optimal to just black out your entire room with curtains, especially if you have LED streetlights outside your house. 

Electronics should also be unplugged so that your room is completely dark. 

If you do these things, you’ll notice a profound difference in your sleep and brain and mental health.

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5. Vitamin E and N-Acetyl-Cysteine (NAC)

Vitamin E and N-Acetyl-Cysteine (NAC) are two nutrients with antioxidant effects. 

One study found that NAC protects against the cellular damage induced by blue LED light (38). 

Perhaps this is one of the reasons NAC helps people who struggle with mental illness

Another study found that a combination of vitamin E and NAC significantly reduced blue-light-induced levels of reactive oxygen species (39). 

Both NAC and Vitamin E are included in the Optimal Antiox supplement.

 

6. Lutein and Zeaxanthin

A broken egg and egg yolk. Egg yolks contain antioxidants that can protect you have excessive blue light exposure.

Lutein and zeaxanthin are two more antioxidants that are found in your eye that may be able to protect you from the detrimental effects of blue light.  

Both zeaxanthin and lutein cannot be made by your body, so you must get them from food or supplements. They are found in green leafy vegetables, orange and yellow-coloured fruits and vegetables, and egg yolks. 

Together, these antioxidants can reduce free radicals before they cause damage and help your body better handle excess blue light. Researchers have found that they “absorb a broader spectrum of high-energy blue light, which offers greater protection of retinal tissue” (12, 13). 

You can also take them together as a supplement. 

 

Conclusion

Nutrition is important. But it's not the be all and end all.

Light is just as important.

Overall, you should aim to limit your exposure to blue light, both during the day and evening. 

Humans evolved getting a full spectrum of light throughout the day, not overwhelming amounts of artificial blue. 

Excessive blue light from LEDs and electronic screens can contribute to illness by triggering an overproduction of reactive oxygen species and decreasing your body’s production of melatonin.

But with the above modifications, you can significantly reduce the amount of blue light that enters your eyes and affects your brain and mental health.

 
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Live Optimally,

Jordan Fallis

Connect with me

References:

(1) https://www.ncbi.nlm.nih.gov/pubmed/20030543

(2) https://www.ncbi.nlm.nih.gov/pubmed/22850476

(3) http://onlinelibrary.wiley.com/doi/10.1111/j.1600-079X.2006.00332.x/full

(4) http://press.endocrine.org/doi/full/10.1210/jc.2004-2062

(5) https://www.ncbi.nlm.nih.gov/pubmed/20030543

(6) http://www.newsweek.com/blue-blocking-glasses-may-help-treat-bipolar-disorder-promote-sleep-484065

(7) http://onlinelibrary.wiley.com/doi/10.1111/bdi.12390/abstract

(8) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047226/

(9) https://www.ncbi.nlm.nih.gov/pubmed/19493002

(10) https://www.newscientist.com/article/dn21127-skin-sees-the-light-to-protect-against-sunshine/

(11) http://onlinelibrary.wiley.com/doi/10.1111/bdi.12390/abstract

(12) http://jn.nutrition.org/content/133/4/992.long

(13) http://www.newhope.com/high-energy-blue-light-exposure-protection-all-ages-white-paper

(14) https://www.ncbi.nlm.nih.gov/m/pubmed/27562504/

(15) https://www.ncbi.nlm.nih.gov/pubmed/7769534

(16) https://www.ncbi.nlm.nih.gov/pubmed/18922088

(17) https://www.ncbi.nlm.nih.gov/pubmed/19837048

(18) https://www.ncbi.nlm.nih.gov/pubmed/21116053

(19) https://www.ncbi.nlm.nih.gov/pubmed/15978279 

(20) https://www.ncbi.nlm.nih.gov/pubmed/9554572/

(21) http://www.newsweek.com/blue-blocking-glasses-may-help-treat-bipolar-disorder-promote-sleep-484065

(22) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200463/

(23) https://www.ncbi.nlm.nih.gov/pubmed/23856285

(24) http://press.endocrine.org/doi/pdf/10.1210/jc.2015-1859

(25) https://www.ncbi.nlm.nih.gov/pubmed/24909301  

(26) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734149/

(27) https://www.ncbi.nlm.nih.gov/pubmed/21415172

(28) https://www.ncbi.nlm.nih.gov/pubmed/21164152

(29) https://www.ncbi.nlm.nih.gov/pubmed/15582288

(30) https://www.ncbi.nlm.nih.gov/pubmed/15325001

(31) http://onlinelibrary.wiley.com/doi/10.1111/jsr.12050/full

(32) http://www.ncbi.nlm.nih.gov/pubmed/23691095

(33) http://bmjopen.bmj.com/content/5/1/e006748

(34) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047226/

(35) http://behavioralandbrainfunctions.biomedcentral.com/articles/10.1186/1744-9081-2-15

(36) https://www.ncbi.nlm.nih.gov/pubmed/16179266

(37) https://www.ncbi.nlm.nih.gov/pubmed/16364209

(38) https://www.ncbi.nlm.nih.gov/pubmed/24909301

(39) https://www.ncbi.nlm.nih.gov/pubmed/15978279

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13 Proven Ways Saunas Can Improve Your Mental Health

When it comes to improving your mental health, some of the simplest strategies can have a huge impact.

Using a sauna regularly is one of them.

Infrared saunas in particular are becoming increasingly popular, and for good reason. 

They have a number of brain and mental health benefits, as discussed in the book Sauna Therapy by Dr. Lawrence Wilson.

However, you don’t necessarily need an infrared sauna to experience health benefits. Even traditional saunas – available at most public gyms, spas and health centres – have a number of beneficial cognitive and psychological effects. 

Once you start using a sauna, you should listen to your body to determine how much time you should spend in it. Start out slowly and increase the length of your sessions over time. Also make sure to drink lots of water before and after each session, and never consume alcohol in combination.

Read on to learn about the 13 ways traditional and infrared saunas can improve your brain and mental health.

Illustration of man sitting in a sauna, improving his mental health one minute at a time.

1. Saunas Improve Mood and Reduce Depression

Saunas can really help people that struggle with depression.

Lots of research shows that they can make you feel euphoric. Saunas are somewhat stressful on the body, so your brain produces and releases more euphoric hormones to deal with it (53-55).

And these changes appear to be semi-permanent (56). 

So if you use a sauna regularly, you'll end up being consistently happy. 

Dr. Jeffrey Lieberman, MD, has completed two studies in which he had people with major depression sit in an infrared sauna.

Woman with hands up in the air, sun setting in the background.

In his first study, the participants had just one infrared sauna treatment and it reduced their symptoms by about 50%.

In his follow-up study, he found that a single session caused a rapid and powerful antidepressant effect, and the benefits continued for six weeks, which was unexpected. 

He concluded that whole-body hyperthermia holds promise as a safe, rapid-acting, antidepressant treatment with a prolonged therapeutic benefit (57-58). 

Other researchers have looked at the effects of infrared sauna therapy on mildly depressed patients with fatigue, appetite loss, and mental complaints. They found that sauna treatment significantly increased their appetite and reduced their mental complaints (59). 

Whole-body heat therapy has also been shown to reduce depression in cancer patients (60-61).

And other research shows that sweating increases mental satisfaction and energy (62). 

 

2. Saunas Reduce Anxiety and Stress

Not surprisingly, saunas can also reduce stress and anxiety.

Several studies have shown that regular sauna use lowers levels of cortisol, your body’s main stress hormone (49-52). 

In one study, researchers found that using a sauna can reduce both state and trait anxiety (48).

And other research shows that sweating increases relaxation, and reduces feelings of frustration and anxiety (62). 

Here are 21 other ways to reduce cortisol and increase your resilience to stress.

 

3. Saunas Increase Beta-Endorphins, Relieve Pain and Help Treat Fibromyalgia

Beta-endorphins are pain-relieving compounds that originate within your body. 

Your brain produces and releases these natural painkillers during times of strenuous exercise, emotional stress and pain.

Since saunas are a stressor, the release of endorphins are increased when you spend time in one.

Illustration of person in pain. Saunas can help reduce the symptoms of fibromyalgia.

Several studies have shown that heat stress and heat exposure in a dry sauna cause a significant increase in beta-endorphin levels (28-32). 

This may explain why research shows that sauna therapy can lessen the pain experienced by patients with fibromyalgia, a chronic syndrome characterized by widespread pain with tenderness in specific areas.

In one study, people with fibromyalgia experienced a 33 to 77 per cent reduction in pain after using an infrared sauna regularly. Six months after the study was done, the participants still reported a 28 to 66 per cent reduction in pain (35). 

Other researchers have found the same thing and concluded that infrared sauna therapy is effective for the treatment of fibromyalgia (33-34). 

Another way to relieve pain is by taking DL-Phenylalanine. It’s an amino acid that inhibits the breakdown of endorphins. I previously wrote about it here.

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4. Saunas Increase Brain-Derived Neurotrophic Factor (BDNF)

A cartoon brain with arms and legs, lifting weights over its head. Saunas increase BDNF.

Brain-derived neurotrophic factor (BDNF) is a naturally-occurring protein in the brain that lowers your risk of mental disease and improves your mood. It does this by protecting and repairing your brain cells and increasing the growth of new brain cells. Many researchers consider it a natural antidepressant because it can reduce anxiety and depression (5-13, 15).

Research suggests that if you struggle with mental illness, you likely have reduced levels of BDNF. But luckily, there are ways to boost it.

Using a sauna is one of the ways. 

Research shows that heat exposure increases the expression of BDNF (14). 

I previously provided 21 other ways to boost BDNF in this post

 

5. Saunas Increase Norepinephrine Levels and May Help Treat Attention Deficit Hyperactivity Disorder (ADHD)

Norepinephrine, also called noradrenaline, is a hormone and neurotransmitter in the brain that can help with focus and attention.

An illustration of a man’s mind being open with lots of arrows. Saunas can help reduce symptoms of ADHD.

Numerous studies have found that sauna use significantly increases norepinepherine levels (39-42). 

In one study, women spent 20 minutes in a sauna, two times each week, and researchers witnessed an 86% increase in norepinephrine (43). 

In another study, men that stayed in a sauna until exhaustion increased their norepinephrine levels by 310% (44-45). 

Besides increasing norepinephrine, heat stress also increases your body’s ability to store norepinephrine for later release (46). 

Medications that increase the reuptake norepinephrine are often prescribed to people with ADHD, so researchers believe that sauna therapy should be considered as an alternative treatment (47). 

 

6. Saunas Encourage the Growth of Myelin

Myelin is a fatty, white substance that wraps around the end of many nerve cells. It forms an electrically insulating sheath that increases nerve condition speeds.

In other words, it allows your brain to send information faster and more efficiently, making it absolutely essential for the optimal functioning of your nervous system.

Illustration of myelin sheath.

Heat stress increases prolactin, a hormone that promotes the production of myelin (16-19). 

In one study, researchers had healthy young men stay in a sauna until they were exhausted, and they reported a 10-fold increase in prolactin (20-11). 

In another study, women spent 20 minutes sauna, two times each week, and researchers witnessed a 510% increase in prolactin (22). 

I previously provided 25 other ways to promote the growth of myelin in this post

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7. Saunas Reduce the Risk of Dementia

Dementia is obviously a major concern today. 

It’s the third leading cause of death in the United States behind cardiovascular disease and cancer, and by 2050, it’s estimated that 13 million Americans and 160 million people globally will be affected by the disease (63).

There is currently a lack of effective treatment options, so simple tools to help with prevention are crucial.

A young woman and elderly woman laughing and smiling. Saunas can help reduce the risk of dementia.

It turns out that sauna therapy may be one of these tools.

Researchers tracked the health of more than 2,300 men in Finland for about 20 years. The men who used a sauna four to seven times each week had a 66 percent lower chance of developing dementia than men who used a sauna just once a week (64-68). 

We have taken into account other lifestyle factors, like physical activity and socioeconomic factors. There is an independent effect of sauna.
— Dr. Jari Laukkanen, Professor of Clinical Medicine at the University of Eastern Finland

I previously provided some other ways to reverse cognitive decline and dementia in this post

Intranasal insulin can also help. 

 

8. Saunas Reduce Psychological Symptoms of Anorexia

Anorexia nervosa, or simply known as anorexia, is an eating disorder characterized by a low weight, fear of gaining weight, a strong desire to be thin, and food restriction.

Researchers have examined the effects of sweating on anorexia and reported positive effects on hyperactivity, depression, and stress levels (27). 

 

9. Saunas Reduce Symptoms of Chronic Fatigue

Chronic fatigue syndrome is a complex, incapacitating illness. It affects millions of people around the world and may affect up to 4 million people in the United States alone. 

People struggling with this disorder not only have unrelenting fatigue lasting for 6 months or more, but also memory and concentration deficits, sleep disturbances, headaches, joint and muscle pain, and gastrointestinal and immune system dysfunction.

A woman holds her forehead, struggling with fatigue. Saunas can help reduce symptoms of chronic fatigue syndrome.

One study found that infrared sauna sessions significantly reduce fatigue in patients with chronic fatigue syndrome. It also significantly reduced their anxiety and depression (23). 

I've had some clients with chronic fatigue say that their doctor recommended they stay out of the sun and avoid exposing themselves to too much heat. But the above study didn't find any negative effects in chronic fatigue patients from regular infrared sauna sessions (23). 

Another study found that daily infrared sauna sessions dramatically improved symptoms of chronic fatigue syndrome, including fatigue, pain and sleep disturbances. The patients in the study didn’t improve with prednisolone, a steroid medication, but did improve with sauna therapy (24).

So if you struggle with chronic fatigue, infrared sauna therapy is definitely worth looking into. 

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10. Saunas Reduce Tension Headaches

"Chronic tension-type headache" is a syndrome characterized by frequent headaches that occur more than 15 days every month. 

The intensity and duration of the headaches can be very distressing and disabling and affect a person's well-being.

But research shows that regular sauna use is a simple, self-directed treatment that is effective for reducing headache pain intensity (26). 

 

11. Saunas Help Eliminate Heavy Metals

Some of the benefits of sauna usage occur because of increased sweating. 

Many people don’t sweat very much, and this can cause problems because your skin acts as an important route of detoxification and helps you excrete heavy metals that are so prevalent in your modern environment. Common heavy metals in our environment include cadmium, arsenic, lead and mercury (36, 37). 

A diagram demonstrating the negative effects of heavy metals on the body. Regular sauna use can help your body excrete heavy metals.

Lack of sweating may actually result in increased toxic load over time, which can negatively affect your brain and mental health.

Research shows that mercury poisoning from dental amalgam affects the mind and emotions and plays a role in the development of mental illness (1). 

But by sweating frequently in a sauna, you can enhance your detoxification pathways and help your body remove mercury (2, 4). 

In fact, studies show that high mercury levels can be reduced to normal levels by using a sauna repeatedly (3). 

Researchers have concluded that “sweat-inducing sauna use can provide a therapeutic method to increase elimination of toxic trace metals and should be the initial and preferred treatment of patients with elevated mercury levels” (38). 

Sweating offers potential and deserves consideration to assist with removal of toxic elements from the body.
— Researchers writing in the Journal of Environmental and Public Health
 

12. Saunas Increase Deep Sleep

Getting high-quality deep sleep is critical for optimal brain function and mental health. 

And using a sauna regularly is one way to improve it. 

Researchers in Finland report that sauna use is one of the factors that can result in deeper, more restful sleep (25). 

This sleep supplement contains magnesium and a number of other natural compounds that I’ve used over the years to deepen sleep.

But I work with my clients so that they can naturally maximize the quality of their sleep without so many supplements. We have free online workshop that talks about how you can work with us. You can register for the workshop here.

 

13. Saunas Support Thyroid Function

Your thyroid is a small butterfly-shaped gland located in your neck below your Adam’s apple, and lots of research shows that thyroid dysfunction can contribute to mental health problems

One of the main threats to the health of your thyroid is non-biological halogens. These include bromine, fluorine, chlorine, and perchlorate, which are often found in tap water.

An illustration showing the thyroid gland.

Your thyroid doesn’t know the difference these halogens and iodine, a trace mineral necessary for proper thyroid function.

Your thyroid soaks up the halogens and uses them like iodine. By occupying iodine receptors, they inhibit the production of your thyroid hormones, and contribute to thyroid dysfunction.

But don’t worry – sauna use can help your body excrete halogens (69). 

The more you can excrete the halogens, the more your body will be able to use iodine to produce thyroid hormones.

I also recommend reducing your exposure by filtering your drinking and shower water. Brita filters aren't enough because they don’t remove fluoride. I use a Berkey water filter to make sure I’m drinking the purest water available. It filters everything out of the water. I also use this filter to remove chlorine from my shower water. 

I highly recommend getting a full thyroid panel done regularly.

Check out this post for more ways to support your thyroid. 

 

Conclusion

As you can see, saunas have a number of beneficial effects on the brain and can help you manage and overcome your mental health challenges. 

I’ve been doing a lot of research into saunas recently and have concluded that infrared saunas have additional benefits and are much more gentle and effective than the traditional “hot rock” saunas.

Unfortunately, most infrared saunas emit unsafe levels of electromagnetic fields (EMFs).

However, I did find a company that has a patent on low-EMF infrared saunas. Their saunas are also very well built and have a lifetime warranty. So I'm going to go with one of their saunas. You can get one here

 
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Live Optimally,

Jordan Fallis

Connect with me

References:

(1) https://www.ncbi.nlm.nih.gov/pubmed/2618948

(2) https://www.ncbi.nlm.nih.gov/pubmed/22315626/

(3) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312275/

(4) https://www.ncbi.nlm.nih.gov/pubmed/3218899/

(5) http://www.hindawi.com/journals/tswj/2009/624894/abs/

(6) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504526/

(7) http://www.sciencedirect.com/science/article/pii/S0006322303001811

(8) http://www.sciencedirect.com/science/article/pii/0896627391902733

(9) http://www.sciencedirect.com/science/article/pii/S0166432812006997

(10) http://www.sciencedirect.com/science/article/pii/S0006899306027144

(11) http://www.ncbi.nlm.nih.gov/pubmed/25568448

(12) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC23964/

(13) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC23964/

(14) https://www.ncbi.nlm.nih.gov/pubmed/21385602

(15) https://www.ncbi.nlm.nih.gov/pubmed/20594764

(16) http://www.ncbi.nlm.nih.gov/pubmed/2830109

(17) https://www.ncbi.nlm.nih.gov/pubmed/15234248

(18) https://www.ncbi.nlm.nih.gov/pubmed/17314279

(19) https://link.springer.com/article/10.1007%2FBF00691246

(20) https://www.ncbi.nlm.nih.gov/pubmed/11165553

(21) https://www.ncbi.nlm.nih.gov/pubmed/2759081

(22) https://www.ncbi.nlm.nih.gov/pubmed/2830109

(23) https://www.ncbi.nlm.nih.gov/pubmed/25748743

(24) http://www.ncbi.nlm.nih.gov/pubmed/15992574/

(25) https://www.ncbi.nlm.nih.gov/pubmed/3363395

(26) https://www.ncbi.nlm.nih.gov/pubmed/25636135

(27) http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0041851

(28) https://www.ncbi.nlm.nih.gov/pubmed/11165553

(29) https://www.ncbi.nlm.nih.gov/pubmed/2759081

(30) https://www.ncbi.nlm.nih.gov/pubmed/3002937

(31) https://www.ncbi.nlm.nih.gov/pubmed/8061252

(32) https://www.ncbi.nlm.nih.gov/pubmed/3218898

(33) https://www.jstage.jst.go.jp/article/internalmedicine/47/16/47_16_1473/_pdf

(34) https://www.jstage.jst.go.jp/article/internalmedicine/47/16/47_16_1473/_article

(35) https://www.ncbi.nlm.nih.gov/pubmed/21742283

(36) https://www.hindawi.com/journals/jeph/2012/184745/

(37) https://www.hindawi.com/journals/jeph/2012/184745/

(38) https://www.hindawi.com/journals/jeph/2012/184745/

(39) http://www.ncbi.nlm.nih.gov/pubmed/2759081

(40) http://www.ncbi.nlm.nih.gov/pubmed/2830109

(41) https://link.springer.com/article/10.1007%2FBF00691246

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(43) https://www.ncbi.nlm.nih.gov/pubmed/2830109

(44) https://www.ncbi.nlm.nih.gov/pubmed/11165553

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