How to Actually Heal and Repair a Leaky Blood-Brain Barrier

“Blood-brain barrier leakage means that the brain has lost its protective means, the stability of brain cells is disrupted and the environment in which nerve cells interact becomes ill-conditioned. These mechanisms could eventually lead to dysfunction in the brain.”

— Dr. Walter H. Backes, Maastricht University Medical Center

A healthy, properly-functioning blood-brain barrier is absolutely critical for optimal brain and mental health.

The blood-brain barrier is a protective shield that surrounds your brain.

It acts as a gatekeeper and filter, allowing beneficial nutrients to cross over into your brain, and keeping unwanted molecules out of your brain.  

But in his book Why Isn’t My Brain Working, Dr. Datis Kharrazian explains that the blood-brain barrier can break down and become “leaky”.

This allows harmful substances to enter your brain, contributing to brain inflammation, which has been shown to cause cognitive problems and mental illness (92, 110-111).

Hyper-permeability of the blood-brain barrier and neuroinflammation have been linked to a number of different brain and mental health problems and symptoms, including depression, anxiety, cognitive impairment, brain fog, Alzheimer's disease, Parkinson’s disease, headaches, migraines, chronic fatigue syndrome, attention deficit hyperactivity disorder (ADHD) and schizophrenia (101-109). 

A number of factors contribute to “leaky brain”, including (93-100):

• Systemic inflammation

• Oxidative stress

• Autoimmune disease

• Chronic psychological stress

• Infections

• Head trauma

• Poor diet and food additives

• Disrupted circadian rhythm

• Intestinal permeability (leaky gut syndrome)

• Excess alcohol consumption

• Environmental toxins and heavy metals

• High blood sugar

• Poor brain blood flow

Needless to say, these things are very common today, so a lot of people likely have a leaky blood-brain barrier.

The good news is that even though the blood-brain barrier can break down and become leaky, it can also be fixed!

You can repair it if you give it what it needs to heal. 

After living in a moldy home and suffering multiple concussions, my brain and its barrier were in rough shape.

Since then, I’ve searched far and wide for solutions that could strengthen it.

Here are 24 strategies that have been shown to support and repair the blood brain barrier.

Many of them have helped me.

Together, they can help you reduce neuroinflammation, heal your “leaky brain,” and overcome your brain and mental health challenges. 

1. Avoid Gluten

Avoiding gluten is necessary for optimal brain and mental health.

I’m convinced that if you struggle with a chronic brain or mental illness, you should follow a strict gluten-free diet for at least 30 days and see how you feel.

You'll likely feel better.

There’s one main reason I recommend this…

Gluten has been shown to elevate “zonulin”.

Zonulin is a protein in your body that increases the permeability of the intestinal barrier and disrupts the blood-brain barrier (48).

Researchers have found that gluten clearly increases zonulin and contributes to “leaky gut” and “leaky brain”, resulting in neuroinflammation and altered cognitive function (49, 50).

Gluten sensitivity can also create visible changes to the white matter in your brain, according to research in The Lancet Neurology (51).

Yet unfortunately, the myth continues to spread that only people with celiac disease need to avoid gluten-containing food.

That’s simply not true.  

Dr. David Perlmutter, MD, author of Grain Brain and Brain Maker, explains:

“Not only is there increased gut permeability when the gut is exposed to gliadin, a protein found in gluten, but in fact the blood brain barrier also becomes more permeable in response to gliadin exposure.”

You should also determine if you have other food sensitivities and remove those foods from your diet as well. A lot of people are sensitive to dairy, along with gluten. I can't tolerate gluten, dairy and egg whites and have to avoid them completely. 

2. Heal Your Gut (and Increase the Good Bacteria Within It)

There is a clear connection between your brain and digestive system.

I’ve discussed this before.

Whatever happens in your gut directly impacts your brain function.

Because of this connection, it’s critical to address gut issues in order to heal a leaky brain.

Researchers have studied mice that are “germ free”.

“Germ-free” mice means that the mice don’t have any bacteria in their intestines.

And what did the researchers find?

They found that these germ-free mice had very leaky blood-brain barriers (56).

But when these germ-free mice received a fecal transfer, where researchers introduced bacteria into their intestines, the permeability of their blood-brain barriers decreased significantly (57).

So it’s becoming increasing clear that our gut bacteria directly affect the health of our blood-brain barrier.

And manipulating your gut bacteria, and increasing the amount of good bacteria in your digestive system, can help improve the integrity of your blood-brain barrier and heal your leaky brain. 

“Given that the microbiome composition and diversity change over time, it is tempting to speculate that the blood-brain barrier integrity also may fluctuate depending on the microbiome.”

— Dr. Sven Pettersson, MD, PhD

In my experience, this is true, as my brain functions much better when I take care of my gut. 

Eating more prebiotic fiber and resistant starch, taking a high-quality probiotic, and eating fermented foods on a regular basis can increase the amount of good bacteria in your gut.

I take Optimal Biotics every day.

You should check out my previous article about gut health to learn more.

And if you have depression or anxiety, taking these probiotics can help.

3. Drink Coffee

Coffee and caffeine are excellent for brain health. There is lots of research showing they are very healthy and can be protective against dementia.

One possible explanation for this is that caffeine supports the blood-brain barrier.

Studies show that caffeine protects against Alzheimer's disease and Parkinson’s disease by keeping the blood-brain barrier intact, and protecting against blood-brain barrier dysfunction and leakage (32).

In one study, researchers found that caffeine blocks the disruption of the blood-brain barrier, concluding that caffeine is “useful in the treatment Alzheimer's disease” (33, 34).

Another study showed that caffeine can protect against Parkinson’s disease and neurodegeneration by stabilizing the blood-brain barrier (35).

I used to not be able to handle any coffee and caffeine at all. But now that I have my anxiety under control, I can handle it just fine. I drink one cup of coffee most mornings.

Coffee and caffeine can disrupt sleep though, so make sure you don’t drink it later in the day. I have my last cup sometime between 10 in the morning and noon. If I have it any later than that, it disrupts my sleep.

There are also additional brain health benefits when you consume the whole coffee fruit, instead of just coffee or pure caffeine. 

Usually, coffee beans are extracted from the whole coffee fruit for roasting. And then the surrounding coffee fruit is then thrown away. 

But this is a problem because the coffee fruit contains several healthy compounds not found in coffee beans themselves.

And researchers have now discovered that ingesting whole coffee fruit concentrate significantly increases brain function.

That’s why I included coffee fruit concentrate in the Optimal Brain supplement. 

4. Sulforaphane

Sulforaphane is a phytochemical found in cruciferous vegetables such as broccoli, Brussels sprouts or cabbages.

It has potent antioxidant and anti-inflammatory actions.

It’s quite similar to curcumin.

Numerous studies have shown that sulforaphane can prevent the breakdown of the blood-brain barrier, reduce permeability of the blood-brain barrier, and improve cognitive function after stroke and traumatic brain injuries (87-91).

You can take sulforaphane in supplement form.

If you decide to take it as a supplement, make sure you get the "myrosinase-activated" form.

Myrosinase is the enzyme in broccoli that helps metabolize sulforaphane.

I once bought a supplement that didn't contain myrosinase and had to return it, and then ended up buying another one instead.

5. Avoid Alcohol

Not surprisingly, alcohol and acetaldehyde – a byproduct of alcohol metabolism – can weaken and damage the blood-brain barrier, and contribute to leaky brain.  

Researchers have found that the oxidative stress that results from excess alcohol consumption leads to blood-brain barrier dysfunction (58, 59).

And this can then lead to neuroinflammation (60).

There are ways to protect your brain from alcohol, but you’re better off avoiding it completely or significantly reducing your consumption if you’re trying to heal.

Some types of alcohol are better than others. You can learn more about the best types of alcohol here. 

 6. Resveratrol or Pterostilbene

Resveratrol is a beneficial antioxidant and anti-inflammatory compound found in grapes, red wine, raspberries and dark chocolate.

It’s known to help prevent the development of neurodegenerative diseases.

And scientists are starting to understand why.

Resveratrol can increase BDNF and support your mitochondria.

And according to cutting-edge research, it can also protect and support your blood-brain barrier.

In a recent study, researchers gave resveratrol to Alzheimer’s patients and it restored the integrity of their blood-brain barriers.

Because of this, there was a reduction in brain inflammation, which slowed down cognitive decline in the patients (38, 39). 

Numerous other studies have found that resveratrol:

• Significantly reduces the breakage, damage and dysfunction of the blood-brain barrier;

• Defends and protects the blood-brain barrier; and

• Improves and maintains the overall integrity of the blood-brain barrier (36-37, 40-43).

“Resveratrol imposes a kind of crowd control at the border of the brain. The agent seems to shut out unwanted immune molecules that can exacerbate brain inflammation and kill neurons.”

— Dr. Charbel Moussa, MD, PhD

Because of resveratrol’s ability to stabilize the blood-brain barrier and protect against neuroinflammation, researchers also believe it may reduce the clinical severity of multiple sclerosis (44).

Lastly, resveratrol has been shown to protects against oxidized LDL-induced breakage of the blood–brain barrier (45, 46).

So clearly resveratrol is great for our blood-brain barriers.

If resveratrol was a pharaceutical drug, we would definitely be hearing more about it. But natural compounds cannot be patented, so we don't.  

Pterostilbene, a compound found in blueberries, is very similar to resveratrol.

It’s also been shown to protect the blood-brain barrier by reducing oxidative stress, and it’s apparently better absorbed than resveratrol. In fact, it’s commonly referred to as a “better resveratrol” (47).

I tried pterostilbene and it was beneficial, but I didn’t find it any more helpful than resveratrol, so I’ve decided to just stick with resveratrol considering it has significantly more research to back it up. 

Resveratrol is included in this supplement.

7. Reduce Stress

I highly recommend you try to do something every day to manage and reduce your stress.

Research suggests that acute stress damages the blood-brain barrier (52).

And extreme stress has been shown to increase inflammation and increase the permeability of the blood-brain barrier (53-55).

But normalizing your stress levels can help the blood-brain barrier repair itself.

The most effective way to significantly reduce your stress and anxiety is neurofeedback. It’s advanced, guided meditation and I previously wrote about my experience with it here.

If you can’t access neurofeedback, taking up a daily meditation practice is an excellent idea.

I’m a big fan of the Muse headband. It’s a device that guides you while you meditation. Similar to neurofeedback, it gives you real-time feedback while you meditate. I wrote an entire review about it here, and you can get the device through the Muse website. 

Regular massage, acupuncture, eye movement desensitization and reprocessing (EMDR), emotional freedom techniques (EFT), heart-rate variability (HRV) training, and an acupressure mat have helped me a lot as well.

Lying on an acupressure mat while using my EmWave2 for just 10 minutes relaxes my entire body and mind. I do this at night before bed.

Some nutrients and herbs that can help you with stress include zinc, magnesium, ashwagandha and phosphatidylserine.

This anti-anxiety supplement also includes a number of natural compounds that have helped me manage my stress over the years.

8. Omega-3 Fatty Acids

Omega-3 fatty acids are essential fats that your body cannot produce itself. So you need to get them from diet or supplements, as they are absolutely necessary for the normal functioning of your brain and nervous system.

Omega-3 fatty acids can support your mitochondria, increase your BDNF levels, and help you overcome addiction and withdrawal.

But they can also support your blood-brain barrier.

Researchers have found that omega-3 fatty acids can: 

• Reduce damage to the blood-brain barrier after stoke;

• Limit blood-brain barrier disruption after traumatic brain injury; and

• Benefit people with multiple sclerosis by indirectly reducing disruption of their blood-brain barriers (76-78).

Wild fish is the best food source of omega-3 fatty acids, but unfortunately, most people don't consume enough omega-3 fatty acids through their diet.

That’s why I recommend supplementing with krill oil, a special kind of fish oil that contains the essential omega-3 fatty acids.

Krill oil also contains astaxanthin, a powerful, naturally occurring carotenoid.

Astaxanthin has also been shown to decrease inflammation and protect the blood-brain barrier (118-119).

9. Sleep and Melatonin

Deep sleep is necessary for the optimal functioning of your blood-brain barrier.

My sleep used to be terrible and it was one of main factors that contributed to my poor brain and mental health. And then my poor brain and mental health would make my sleep worse. So it was a vicious cycle.

Sleep restriction has been shown to impair the functioning of the blood-brain barrier and increase its permeability (84).

So you should really try to get at least 7 hours of high-quality, restorative sleep every night.

Supplementing with melatonin can also help.

Melatonin is a hormone released by your pineal gland, a small gland in your brain. Melatonin helps control your sleep and wake cycles (circadian rhythm).

Adequate levels of melatonin are necessary to fall asleep quickly and sleep deeply throughout the night.

Research also shows that melatonin can stabilize the blood-brain barrier and prevent damage caused by traumatic brain injury (85, 86).

This sleep supplement contains magnesium and a number of other natural compounds that I’ve used over the years to promote the production of melatonin.

But I work with my clients so that they can naturally produce more melatonin and maximize the quality of their sleep without so many supplements. We have free online workshop that talks about how you can work with us. You can register for the workshop here.

10. Berberine

Berberine is an alkaloid extracted from various plants. 

It has anti-inflammatory, neuroprotective and possibly antidepressant effects. It can also improve intestinal health and lower cholesterol.

And several studies have shown that it can decrease the permeability of the blood-brain barrier and reduce brain damage after traumatic brain injury. It does this by suppressing inflammation (23-26). 

I’ve experimented with varying dosages of berberine. I personally didn’t notice any profound brain and mental health benefits, but I have heard good things about berberine from other people. 

11. Avoid Environmental Mold and Mycotoxins

Environmental mold can be a serious problem for some people.

Unfortunately, most people aren’t even aware that mold is in their home or workplace and affecting their brain function.

In water-damaged buildings, mycotoxins (toxic metabolites produced by mold) are released into the air.

If you’re genetically susceptible, they can wreak havoc on your brain, and your cognitive function and mental health can deteriorate for no apparent reason.

One way mold and mycotoxins can disrupt brain function is by causing “leaky brain.”

Researchers have discovered that mycotoxins can clearly reduce the integrity of the blood-brain barrier (62).

They’ve also concluded that exposure to mycotoxins in an indoor environment can cause neurological damage. One way it does this is by breaking down the blood-brain barrier (61).

Several other studies have found that mycotoxins increase the permeability of blood-brain barrier and disrupt the functioning of the nervous system (63-66).

I lived in a moldy house for more than a year, and my blood-brain barrier likely became significantly leaky during that time, as my brain and mental health deteriorated. I also suffered a terrible concussion while living in that house, making my brain even more permeable. It took a while to get back to normal.

Today I use an air filter in my apartment to protect myself from any mold. It removes any mold spores and smoke that may be in the air.

Mycotoxins aren’t just in your environment though. Low amounts of mycotoxins are also often found in some seemingly healthy foods, such as tea, nuts, coffee and chocolate. I recommend finding the freshest, highest-quality, organic versions of these foods.

If I'm exposed to mold or their toxins, I supplement with activated charcoal or bentonite clay. Activated charcoal and bentonite clay are potent natural treatments that can trap toxins and chemicals, allowing them to be flushed out of your body.

12. B Vitamins

Several B vitamins have been shown to support the blood-brain barrier and help heal leaky brain.

Vitamin B1 (thiamine) deficiency disrupts the blood-brain barrier, and supplementing with Vitamin B1 restores its integrity (80-81).

Researchers have also found that vitamins B12, B6, and B9 (folate) can restore the integrity of the blood-brain barrier in adults that have elevated homocysteine levels and mild cognitive impairment. Homocysteine is an inflammatory compound that can contribute to blood-brain barrier breakdown at high levels, and the B vitamins normalize homocysteine levels (82-83).

A number of B vitamins are included in this supplement.

13. Magnesium

Magnesium is a vital mineral that plays a key role in more than 300 biochemical reactions in your body.

It impacts your neurotransmitters and hormones, both of which can significantly impact your mood and brain function.

Magnesium is one of the three nutrients that I think everyone should be taking for their brain, because most people are deficient nowadays.

Research shows that it can support your mitochondria, protect your brain from alcohol, increase your BDNF levels, and help you overcome addiction and withdrawal.

And there is plenty of research showing that it can protect and support your blood-brain barrier as well.

Multiple studies have found that magnesium protects the blood-brain barrier, prevents its disruption, and significantly reduces hyperpermeability of the blood-brain barrier (27, 28, 31).

One study found that it decreases blood-brain barrier permeability by 41% (29).

Magnesium’s protective effect against blood-brain barrier hyperpermeability has also been seen after traumatic brain injury (30).

Foods that contain magnesium include spinach, chard, pumpkin seeds, almonds, avocado, dark chocolate and bananas. These foods are included in my Free Grocery Shopping Guide for Optimal Brain Health.

But supplementation and taking Epsom salt baths is still necessary for most people because magnesium is rapidly used up during times of stress and certain psychiatric drugs can deplete magnesium.

14. Alpha Lipoic Acid (ALA)

Alpha Lipoic Acid (ALA) is an antioxidant produced by your body.

It can also be taken as a supplement.

ALA is fat soluble and can easily cross the blood-brain barrier to protect your brain (1-3).

As I’ve discussed before, it can protect your brain from alcohol and support the mitochondria in your brain.

But not only can it cross your blood-brain barrier and support your brain; it can also support your blood-brain barrier itself.

Studies show that ALA has neuroprotective effects, and it maintains the integrity of the blood-brain barrier by reducing oxidative stress (4-5)

Researchers also point out that its anti-inflammatory and antioxidant effects can stabilize the blood-brain barrier. This makes it an “attractive therapeutic agent for the treatment” of multiple sclerosis and traumatic brain injury (6-8).

ALA is included in the Optimal Antiox supplement.

15. Acetyl-Carnitine (ALCAR)

Acetyl-L-carnitine (ALCAR) is an acetylated form of the amino acid carnitine.  

It’s been shown to have neuroprotective and cognitive-enhancing effects. It’s often used as a natural brain booster because it increases alertness and provides support to brain cells.  

ALCAR has also been shown to be very effective at alleviating chronic fatigue and improving mood. It helps reverse neurological decline and supports mitochondria function as well. 

It does so much, so not surprisingly, researchers have also found that ALCAR helps repair the blood-brain barrier by reversing mitochondria decay caused by oxidative damage (122).

I find that ALCAR personally gives me a big boost in mental energy and cognitive function.  

That’s why it’s included in the Optimal Brain supplement. 

Make sure you read this article to learn more about the remarkable benefits of ALCAR.

16. Curcumin

Curcumin is the most heavily researched compound within turmeric, the spice that gives curry its yellow colour.

Curcumin is one of my favourite compounds for the brain. It can lower your cortisol levels and increase your BDNF levels.

But it can also:

• Reduce the disruption and hyperpermeability of the blood-brain barrier;

• Reverse blood-brain barrier dysfunction; and

• Improve the overall integrity of the blood-brain barrier (13-18).

Studies have also shown that curcumin can prevent blood-brain barrier damage and reduce the permeability of the blood-brain barrier caused by oxygen and glucose deprivation (20-22).

Researchers believe it can do all of this because it significantly reduces inflammation and oxidative stress (19).

Curcumin can be found in this supplement.

17. Vitamin D

Vitamin D is a fat-soluble vitamin that your skin synthesizes when it’s exposed to the sun.

Every tissue in your body has vitamin D receptors, including the brain, heart, muscles, and immune system.

This means your entire body needs it to function properly and a deficiency can lead to costly physiological and psychological consequences.

Researchers have found that Vitamin D can prevent the disruption of the blood-brain barrier, mainly by reducing inflammation (72, 73).

In patients with multiple sclerosis, Vitamin D has been shown to protect endothelial cells and reduce blood-brain barrier disruption (74).

And one study found that intranasal administration of vitamin D reduces blood–brain barrier disruption (75).

I personally take a Vitamin D3 supplement to make sure my Vitamin D levels are optimal.

It's important to test and monitor your Vitamin D levels before and after supplementing with it.

18. Citicoline or Alpha GPC

Choline is an essential nutrient that most people don’t consume enough of because very few foods in the Western diet contain it.

Citicoline (also known as CDP-Choline) is the most bioavailable supplemental form of choline.

As I’ve discussed before, it can help you overcome brain fog and addiction.

But it’s also been shown to significantly decrease the disruption and breakdown of the blood-brain barrier after traumatic brain injury (11-12).

And after brain ischemia, Citicoline significantly reduces blood-brain barrier dysfunction (10).

I personally take Citicoline every day.

It helps me a lot because I’ve had multiple concussions. 

Make sure you read this article to learn more about the remarkable benefits of Citicoline.

Alpha GPC is another excellent form of choline that has been shown to support the blood-brain barrier.

Researchers have found that it improves cognitive function by reversing the changes to the blood-brain barrier after a brain injury (9).

Make sure you read this article to learn more about the benefits of Alpha GPC, the optimal dosage, and the best way to take it.

You can find some choline in beef liver and egg yolks, but both Citicoline and Alpha GPC have much more noticeable and immediate effects.  

Both citicoline and Alpha GPC are included in the Optimal Brain supplement. 

19. Reduce Exposure to Electromagnetic Fields (EMFs)

“I have no doubt in my mind that, at the present time, the greatest polluting element in the Earth’s environment is the proliferation of electromagnetic fields.” - Dr. Robert Becker, Nobel Prize nominee and author of The Body Electric: Electromagnetism And The Foundation Of Life

An increasing amount of research is showing that radiofrequency electromagnetic fields emitted from Wi-Fi, laptops, and cellphones can negatively affect the brain and produce widespread neuropsychiatric effects including depression.

It’s an inconvenient truth that needs to be talked about, rather than downplayed, ignored and dismissed.

One way that radiofrequency EMFs may be causing neuropsychiatric effects is by contributing to a "leaky brain".  

Several studies have found that EMFs emitted from cellphones increase the permeability of the brain-blood barrier, and this increased permeability may lead to the accumulation of brain tissue damage and cognitive impairment (112-114). 

I encourage you to check out my other post about EMFs here. 

I'm still learning about how to manage and combat them, but here are some initial steps you can take:

• Get an EMF meter to determine your exposure. I use the Cornet ED88T. It's the best option that is currently available. It measures electric, magnetic and radiofrequency fields. It's like having three meters in one. You can get it here.

• Put your phone on airplane mode when you’re not using it and/or use a radiation-blocking phone case such as Safe Sleeve. I did a lot of research into radiation-blocking cases and Safe Sleeve is the best on the market. They are manufactured with materials that have been 3rd-party tested to block 99.9% of radiation coming off a cell phone.

• Turn off Wi-Fi at night while you’re sleeping.

• If you have a laptop, don’t touch it. Use a wired keyboard and wired mouse instead.

• Supplement with the herb Rhodiola. It has radioprotective effects (60-62). I previously wrote about it here.

This is just the tip of the iceberg. There are many other steps you can take, and I plan on writing more about this soon because it isn’t discussed enough.

This may seem like “woo-woo” but it’s a real issue. And I suspect it will eventually become one of the biggest issues of our time.

20. Lower Homocysteine

Homocysteine is an amino acid that is produced in the body as a result of methylation.

In healthy people, it’s properly metabolized and normal levels are maintained. 

But when homocysteine isn’t properly metabolized, it can build up inside the body and levels can become too high.

And that’s when homocysteine becomes dangerous and unhealthy. 

At high levels, homocysteine is inflammatory, and research shows it increases permeability of the blood-brain barrier (115).

You can check your homocysteine levels by ordering this blood test. 

If you test and find out your levels are high, check out this article for 16 ways to lower your homocysteine levels.

Normalizing homocysteine not only helps the brain recover from physical damage, but also reduces depression and cognitive decline.

21. Progesterone

Progesterone is a natural steroid and sex hormone involved in the menstrual cycle and pregnancy.  

It has a variety of important functions in the body, and even plays an important role in brain function.  

Research has found that progesterone supports the normal development of brain cells and protects them from damage. 

And one study shows that it reduces inflammation and can support the blood-brain barrier after brain injury (120).

In addition to its role as a natural hormone, progesterone can be taken as a medication, usually by women during menopause as part of their hormone replacement therapy. 

22. Increase Brain Blood Flow

Brain blood flow, or cerebral blood flow, refers to the blood supply that reaches your brain during a given period of time. 

Your brain needs almost 20% of the blood supply provided by each heartbeat.

A steady flow of blood brings oxygen, glucose and nutrients to the brain, and carries carbon dioxide, lactic acid, and other metabolic waste products away from the brain.

But when blood flow to the brain is impaired, problems can arise, including a leaky blood-brain barrier.

Research shows that lack of brain blood flow increases oxidative stress, damages the blood-brain barrier, and increases blood-brain barrier permeability (116-117).

Be sure to check out this post for 21 ways to increase blood flow to the brain.

23. Vagus Nerve Stimulation

The vagus nerve is the longest cranial nerve in your body and part of your parasympathetic “rest and digest” nervous system.

Research shows that stimulating the vagus nerve can decrease blood-brain barrier disruption.

In fact, researchers have found that vagus nerve stimulation can prevent the increase in blood-brain barrier permeability after a traumatic brain injury, and reduce it after a stroke (123-124).

So how do you stimulate your vagus nerve naturally?

I previously provided 13 ways to activate your vagus nerve in this post.

Deep breathing with the EmWave2 device is my favourite way. 

24. Intermittent Fasting

Fasting is another great way to strengthen your blood-brain barrier.

It allows your digestive system to take a break, and triggers a number of hormones that boost your body’s ability to repair itself.

Ghrelin, a hunger-stimulating hormone, signals to your body that it’s time to eat. And it increases when you are fasting.

Researchers have found that that ghrelin improves the integrity of the blood-brain barrier and reduces the breakdown of the blood-brain barrier after a traumatic brain injury (125).

As a result, fasting can help treat neurological conditions and lowers the risk of cognitive decline and neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.

This is why I personally eat all my food for the day within an 8-hour window, and then fast for the other 16 hours of the day.

You don’t need to go that long, but you should try to fast for at least 12 hours at a time.

The best way to get started is simply by eating dinner around 6, not eating anything after that before bed, and then eating a regular breakfast the next day.

That should give you about 12-14 hours of fasting time.

25. BONUS: Other Nutrients, Antioxidants and Herbs

Here are several other nutrients, antioxidants and herbs that have been demonstrated to support the blood-brain barrier.

I’ve decided to not write about these in-depth because there isn’t as much research to back them up.

That doesn’t mean they aren’t useful though. They have still helped me: 

• Vitamin C (67)

• Iodine (68)

• Selenium (69)

• Vitamin E (69)

• N-Acetyl-Cysteine (70)

• Ginseng (71)

• Inositol (79)

• Ursolic Acid (121)

Conclusion

The brain has a remarkable ability to heal itself, and this includes the barrier that protects it.

The above steps have been proven to help repair and support the blood brain barrier, and I’ve noticed the benefits of implementing them into my own life.

I hope they help you too!

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Live Optimally,

Jordan Fallis

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References:

(1) http://www.berkeley.edu/news/media/releases/96legacy/releases.96/14316.html

(2) http://www.ncbi.nlm.nih.gov/pubmed/11854488

(3) http://www.ncbi.nlm.nih.gov/pubmed/11854529

(4) https://www.ncbi.nlm.nih.gov/pubmed/8958163

(5) https://www.ncbi.nlm.nih.gov/pubmed/19823933

(6) https://www.researchgate.net/publication/26240443_The_protective_effect_of_alpha_lipoic_acid_against_traumatic_brain_injury_in_rats

(7) https://www.researchgate.net/publication/6898853_Lipoic_Acid_Affects_Cellular_Migration_into_the_Central_Nervous_System_and_Stabilizes_Blood-Brain_Barrier_Integrity

(8) http://www.ncbi.nlm.nih.gov/pubmed/16888025

(9) https://www.ncbi.nlm.nih.gov/pubmed/25714975

(10) https://www.ncbi.nlm.nih.gov/pubmed/10561698

(11) https://www.ncbi.nlm.nih.gov/pubmed/12691414

(12) http://www.ncbi.nlm.nih.gov/pubmed/10701532

(13) http://www.sciencedirect.com/science/article/pii/S0022480416303638

(14) https://www.ncbi.nlm.nih.gov/pubmed/26686249

(15) https://www.researchgate.net/publication/307999386_Curcumin_attenuates_blood-brain_barrier_disruption_after_subarachnoid_hemorrhage_in_mice

(16) https://www.ncbi.nlm.nih.gov/pubmed/23494637

(17) http://www.fasebj.org/content/28/1_Supplement/1120.9

(18) http://search.bvsalud.org/ghl/resource/en/wpro-668812

(19) http://www.ncbi.nlm.nih.gov/pubmed/26708209

(20) https://www.ncbi.nlm.nih.gov/pubmed/17303117

(21) http://link.springer.com/article/10.1007/s12031-013-9989-4

(22) http://www.ncbi.nlm.nih.gov/pubmed/23494637

(23) https://www.ncbi.nlm.nih.gov/pubmed/20976070

(24) https://www.ncbi.nlm.nih.gov/pubmed/25546475

(25) https://figshare.com/articles/_Post_injury_berberine_treatment_attenuated_brain_edema_blood_brain_barrier_BBB_permeability_matrix_metalloproteinase_MMP_9_enzymatic_activity_neutrophil_infiltration_and_ICAM_expression_after_TBI_/1324009

(26) https://www.ncbi.nlm.nih.gov/pubmed/22560097

(27) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1065104/

(28) https://www.ncbi.nlm.nih.gov/pubmed/15519365

(29) https://www.ncbi.nlm.nih.gov/pubmed/17933863

(30) https://www.ncbi.nlm.nih.gov/pubmed/12657997

(31) https://www.ncbi.nlm.nih.gov/pubmed/11599780

(32) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086010/

(33) http://www.ncbi.nlm.nih.gov/pubmed/18387175

(34) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2330033/

(35) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692355/

(36) https://www.ncbi.nlm.nih.gov/pubmed/25330860

(37) http://link.springer.com/article/10.1007/s12031-014-0441-1

(38) https://gumc.georgetown.edu/news/Resveratrol-Appears-to-Restore-Blood-Brain-Barrier-Integrity-in-Alzheimers-Disease

(39) https://www.sciencedaily.com/releases/2016/07/160727140041.htm

(40) https://www.ncbi.nlm.nih.gov/pubmed/22331300

(41) http://www.ncbi.nlm.nih.govhttp://www.ncbi.nlm.nih.gov/pubmed/23791503pubmed/23791503

(42) https://www.ncbi.nlm.nih.gov/pubmed/24694235

(43) http://www.ncbi.nlm.nih.gov/pubmed/26454022

(44) https://www.ncbi.nlm.nih.gov/pubmed/27535376

(45) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575886/

(46) https://www.ncbi.nlm.nih.gov/pubmed/20980646

(47) https://www.ncbi.nlm.nih.gov/pubmed/26086685

(48) http://physrev.physiology.org/content/91/1/151

(49) http://www.ncbi.nlm.nih.gov/pubmed/16635908

(50) http://www.ncbi.nlm.nih.gov/pubmed/21248165

(51) https://www.ncbi.nlm.nih.gov/pubmed/20170845

(52) http://www.ncbi.nlm.nih.gov/pubmed/11146058

(53) https://www.ncbi.nlm.nih.gov/pubmed/22906518

(54) http://www.nature.com/nm/journal/v2/n12/abs/nm1296-1307.html

(55) http://www.ncbi.nlm.nih.gov/pubmed/11146058

(56) http://stke.sciencemag.org/content/7/353/ec333

(57) https://www.ncbi.nlm.nih.gov/pubmed/25411471

(58) http://www.ncbi.nlm.nih.gov/pubmed/16204625

(59) https://www.ncbi.nlmhttps://www.ncbi.nlm.nih.gov/pubmed/17241155nih.gov/pubmed/17241155

(60) https://www.ncbi.nlm.nih.gov/pubmed/16550326

(61) http://www.ncbi.nlm.nih.gov/pubmed/20549560

(62) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658139/

(63) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179161/

(64) https://www.ncbi.nlm.nih.gov/pubmed/9771558

(65) https://www.ncbi.nlm.nih.gov/pubmed/15994020

(66) https://ttu-ir.tdl.org/ttu-ir/handle/2346/13628

(67) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944243/

(68) http://www.ncbi.nlm.nih.gov/pubmed/9232629

(69) http://www.ncbi.nlm.nih.gov/pubmed/17848733

(70) https://www.ncbi.nlm.nih.gov/pubmed/10591399/

(71) http://www.ncbi.nlm.nih.gov/pubmed/24462216

(72) https://www.ncbi.nlm.nih.gov/pubmed/25815722

(73) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376709/

(74) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678220/

(75) http://jcb.sagepub.com/content/early/2016/09/21/0271678X16671147.abstract

(76) https://www.ncbi.nlm.nih.gov/pubmed/24342130

(77) https://etsmjournal.biomedcentral.com/articles/10.1186/s13231-014-0012-0

(78) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140187/

(79) http://www.ncbi.nlm.nih.gov/pubmed/2525678

(80) http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1999.tb07866.x/abstract

(81) https://www.ncbi.nlm.nih.gov/pubmed/1939760

(82) http://www.ncbi.nlm.nih.gov/pubmed/12826740

(83) https://www.karger.com/Article/Pdf/71002

(84) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212067/

(85) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001216/

(86) http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0154427

(87) https://www.ncbi.nlm.nih.gov/pubmed/19515491

(88) https://www.ncbi.nlm.nih.gov/pubmed/24017972

(89) http://www.ncbi.nlm.nih.gov/pubmed/17881530

(90) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745957

(91) https://www.ncbi.nlm.nih.gov/pubmed/21259333

(92) https://www.ncbi.nlm.nih.gov/pubmed/16081203

(93) https://www.sciencedaily.com/releases/2014/06/140602104749.htm

(94) https://www.ncbi.nlm.nih.gov/pubmed/12935941

(95) https://www.ncbi.nlm.nih.gov/pubmed/10329964

(96) https://www.ncbi.nlm.nih.gov/pubmed/16204625

(97) https://www.ncbi.nlm.nih.gov/pubmed/19659460

(98) https://www.ncbi.nlm.nih.gov/pubmed/14554098

(99) http://www.nature.com/ejcn/journal/v62/n4/full/1602866a.html

(100) https://www.ncbi.nlm.nih.gov/pubmed/18606459

(101) https://www.sciencedaily.com/releases/2016/05/160531081800.htm ;

(102) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023063/

(103) https://www.ncbi.nlm.nih.gov/labs/articles/11461179/

(104) https://www.hindawi.com/journals/cpn/2009/278531/

(105) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626880/

(106) https://www.ncbi.nlm.nih.gov/pubmed/27243267

(107) https://www.ncbi.nlm.nih.gov/pubmed/17503739

(108) https://www.ncbi.nlm.nih.gov/pubmed/26607405

(109) http://www.sciencealert.com/scientists-think-a-leaky-blood-brain-barrier-is-connected-to-alzheimer-s

(110) https://www.ncbi.nlm.nih.gov/pubmed/20644946

(111) https://www.ncbi.nlm.nih.gov/pubmed/15694227

(112) https://www.ncbi.nlm.nih.gov/pubmed/12675022

(113) https://www.ncbi.nlm.nih.gov/pubmed/15381788

(114) https://www.ncbi.nlm.nih.gov/pubmed/12628496

(115) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158726/

(116) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949263/

(117) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068281/

(118) https://www.ncbi.nlm.nih.gov/pubmed/24948541

(119) https://www.ncbi.nlm.nih.gov/pubmed/24948541

(120) https://www.ncbi.nlm.nih.gov/pubmed/25120639

(121) https://www.ncbi.nlm.nih.gov/pubmed/25026072

(122) http://onlinelibrary.wiley.com/enhanced/doi/10.1196/annals.1320.010

(123) https://www.ncbi.nlm.nih.gov/pubmed/22695423

(124) https://www.ncbi.nlm.nih.gov/pubmed/29496430

(125) http://online.liebertpub.com/doi/abs/10.1089/neu.2011.2053

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9 Supplements Proven to Help You Overcome Addiction and Withdrawal

I've been dependent on a lot of substances over the years.

When my brain wasn’t working and I struggled with mental illness, it simply made sense to find immediate relief.

I had to rely on substances outside of myself - even if they weren't good for me - until I found better, long-term, sustainable solutions.

I honestly felt like I had no other choice at the time.

And I know there are a lot of people out there grappling with the same problem.

You may feel like you need something to get through the day.

And then something else to fall asleep at night.

Perhaps that’s alcohol, cigarettes, cannabis or harder substances like cocaine, heroin, methamphetamines.

Or maybe you’re on prescription medication, such as antidepressants or benzodazipenes.

And you just have no idea how you could possibly live without these substances.

I’m here to tell you that you can. And you can thrive.

These 9 nutrients, vitamins and supplements have helped me minimize withdrawal symptoms, overcome my addictions, and get on with my life. 

I personally have experience with tobacco, nicotine, alcohol, stimulant, benzodiazepines and antidepressant dependence, addiction and withdrawal. 

And even if you don’t struggle with addiction, these nutrients are still great for optimal brain function and mental health.  

How Does Nutrition And Supplementation Impact Addiction?

Addiction is not simply a psychological issue.

Historically, most drug treatment programs have included counseling and 12-step approaches like Alcoholics Anonymous (AA).

But these traditional approaches are not very effective.

In her book Seven Weeks to Sobriety, Dr. Joan Mathews Larsen points to studies showing that AA has a success rate of about 25 per cent. 

This is because they address the psychological aspects of addiction without considering the physical aspects of the disease.

And Dr. Charles Gant worked as the physician and psychiatric consultant for the New York State prison system, and dealt with hundreds of drug users and traffickers.

He realized that they wouldn’t overcome their addictions without addressing their physical health:

“Unless the biochemical imbalances which are the true causes of substance problems are corrected, the benefits of psychological counseling will be marginal for most people.”

— Dr. Charles Gant

Addiction is a chronic brain disease. Studies show that drugs physically change the structure and functioning of the brain, and these documented brain changes lead to cravings (96). 

And in my experience and research, high-quality bioavailable nutrients are an important aspect of combating and correcting this.

Research shows that vitamin and mineral deficiencies can cause metabolic imbalances that create addictive cravings (97, 98). 

Dr. Roger Williams, an American biochemist who discovered pantothenic acid (vitamin B5), found that rats that were deficient in certain vitamins consumed more alcohol than those that were not vitamin deficient. But once those vitamin deficiencies were fixed, alcohol consumption decreased (99). 

Nutritional deficiencies can also cause withdrawal-like symptoms such as fatigue, depression, irritability, and other mental symptoms that block recovery and lead to a relapse.

So, without further ado, let’s get into nutrients and supplements that helped me the most. with my addiction and withdrawal, and explore the research behind them.

1. Citicoline

Citicoline (also known as CDP-Choline) is the most bioavailable form of choline.

Choline is an essential B vitamin that most people don’t consume enough of, because very few foods in the Western diet contain it. That’s why I recommend supplementing with it.

Citicoline has anti-inflammatory and neuroprotective effects, and enhances the synthesis of acetylcholine and dopamine, which are two neurotransmitters that are critical for optimal brain function. It also increases the number of acetylcholine and dopamine receptors in your brain (2-7). 

Overall, citicoline is one of my favourite supplements for optimal brain function and mental health. 

And there’s evidence that it helps reduce addiction to drugs (1). 

In one study, people previously addicted to cocaine took 500mg of citicoline twice daily for two weeks and experienced a reduction in cravings for the drug (8).

In another study, people with cocaine dependence and bipolar disorder who supplemented with citicoline reduced their cocaine use. Researchers had directed them to not consume cocaine during the study, and at the end of it, the researchers found less cocaine in the urine of the participants (9). 

Some preliminary research also suggests citicoline could help people with alcohol, cannabis and food addiction (10). 

It’s important to point out that many prescription drugs are anticholinergic, meaning they reduce acetylcholine in the brain.

The commonly-prescribed antidepressant Wellbutrin is anticholinergic, meaning it inhibits the physiological action of acetylcholine. I took it for multiple years, and I experienced gradual cognitive decline during that time. 

Once I got off Wellbutrin, I felt pretty terrible. But once I started supplementing with citicoline, I noticed an improvement in my cognitive function because it increased my levels of acetylcholine and dopamine. I still take it to this day because it helps me focus, improves my mental energy, and clears brain fog. 

You can also find some choline in beef liver and egg yolks. That's why I'm a big fan of eating these foods regularly. They’re included in my Free Grocery Shopping Guide for Optimal Brain and Mental Health.

But supplementing with citicoline has a more immediate, noticeable effect.

Citicoline is included in the Optimal Brain supplement.

Make sure you read this article to learn more about the remarkable benefits of Citicoline.

2. Theanine 

Theanine is a relaxing amino acid found in tea. It has a number of brain and mental health benefits.

It’s known to produce a calming effect on the brain by crossing the blood-brain barrier and increasing the production of both GABA and dopamine in the brain. Unlike prescription anti-anxiety medication, it does not cause sedation and drowsiness (13, 14, 15). 

As I’ve discussed before, theanine can protect your brain from alcohol, increase your brain’s growth hormone, and lower your stress hormones. 

Considering all of this, it’s not too surprising that it has anti-addictive properties and can help reduce withdrawal symptoms.

According to the research, it’s particularly helpful when it comes to withdrawal from nicotine and opioids (16, 17). 

I find that theanine improves my mood, helps me focus and cancels out the jitters of my morning coffee. It’s sort of like meditation in a pill. My mind has a tendency to jump around a lot, and theanine helps me “zero in” on what I’m doing. 

However, too much theanine can also make people anxious. This is because theanine increases alpha brain waves, and I found out that very high alpha brain waves can actually cause anxiety as well. I usually take just 200 mg, but you should experiment and see how much you can tolerate. 

You can also get theanine from black and green tea. But there’s usually not enough theanine in them to have a dramatic effect. That’s why I supplement with pure theanine.

Theanine is available in this anti-anxiety supplement, along with a number of other natural compounds that have helped me manage my anxiety over the years.

3. Omega-3 Fatty Acids

Omega-3 fatty acids are essential fats that the body cannot produce itself.

They are found primarily in fish and are necessary for the normal functioning of your brain and nervous system (18).

They can support your mitochondria and increase your brain’s growth hormone, and have been shown to improve mood, sleep, learning and memory. They also protect against psychiatric disorders including depression, mild cognitive impairment, dementia and Alzheimer's disease (19-21). 

Considering all this, it’s not too surprising them that omega-3 fatty acids can also help addicts and reduce their withdrawal symptoms.

Research shows that increased anxiety is one of the primary reasons why substance abusers and alcoholics tend to relapse (23, 24). 

And one study found that giving omega-3 fatty acids to substance abusers significantly reduced their anxiety (22). 

Smokers have lower levels of omega-3 fatty acids, and treatment with fish significantly reduces their level of dependence (25, 28). 

Other studies have shown that omega-3 supplements reduce cravings for nicotine and reduce the number of cigarettes people smoke daily (26, 27). 

Researchers have also studied the relapse rates of cocaine addicts discharged after a period of detoxification. And they found that the cocaine addicts who relapsed had significantly lower levels of omega-3 fatty acids in comparison to addicts who didn’t relapse (29). 

Lastly, in abstinent alcoholics, elevated omega-3 intake reduces stress and cortisol, and omega-3 fatty acids significantly lower the desire for alcohol in mice (30, 31). 

“These bipolar mice, like some bipolar patients, love alcohol. The mice on DHA (an omega-3 fatty acid) drank much less; it curtailed their alcohol abusive behavior. There is now substantial evidence at the molecular level that omega-3 fatty acids work on the brain in ways similar to psychiatric drugs.”

— Dr. Alexander B. Niculescu, M.D., Ph.D.

Unfortunately, most people don't consume enough omega-3 fatty acids through their diet. That’s why I recommend people supplement with krill oil, a special kind of fish oil that contains the essential omega-3 fatty acids. I find that I have a brighter outlook on life when I take krill oil consistently. 

4. Acetyl-L-Carnitine (ALCAR)

Acetyl-L-Carnitine (ALCAR) is an acetylated form of the amino acid carnitine.

It has neuroprotective and cognitive-enhancing effects, and as I’ve discussed before, it can support your mitochondria, protect your brain from alcohol, and help you overcome brain fog. 

It can also reduce cravings and withdrawal symptoms. 

In one study, alcoholic patients treated with ALCAR stayed sober for longer because it reduced their cravings (48). 

ALCAR can also help treat opiate addiction and withdrawal.

Thirty subjects with methadone dependence were given 2 grams of ALCAR daily during a 3-week detoxification period, and it reduced their pain and the length of their withdrawal (49). 

And research in rats shows that ALCAR can significantly decrease alcohol consumption and reduce the onset of tremors during alcohol withdrawal. Researchers concluded that it should be considered in the treatment of alcohol dependence (50). 

ALCAR gives me a huge boost in mental energy and resilience. It sort of feels like drinking a cup of coffee, so it’s helpful if you want to stop or reduce your intake of caffeine.

It's included in the Optimal Brain supplement.

Make sure you read this article to learn more about the remarkable benefits of ALCAR.

5. N-Acetyl-Cysteine (NAC) and/or Glutathione

N-acetyl-cysteine (NAC) is a modified form of the amino acid cysteine.

As I’ve discussed before, it can help treat several mental illnesses.

But it can also reduce addiction and cravings during withdrawal (32-34, 41, 42, 45):

• In a small study, 13 people abstaining from cocaine were given NAC or placebo over two days. The participants who received NAC witnessed a significant reduction in their withdrawal symptoms and cravings for cocaine. Follow-up studies also showed that NAC reduced desire and interest in cocaine (35-37).

• Smokers voluntarily reduced their cigarette use by around 25% after two weeks of supplementing with NAC (38, 39).

• Young marijuana users claiming to be addicted to marijuana supplemented with NAC twice daily for four weeks and experienced a significant reduction in their symptoms of addiction (43, 44).

• And it’s not just addiction to drugs. NAC also shows promise for the treatment of gambling addiction. A randomized control trial with 27 pathological gamblers showed that gamblers who supplemented with NAC scored 60% lower on the “Obsessive Compulsive Scale for Pathological Gambling." (40).

NAC is also the precursor to glutathione, your body’s master antioxidant, which can help fight addiction. 

Chronic use of drugs, such as cocaine, methamphetamine and alcohol, can lead to the formation of oxidative stress (47). 

Oxidative stress can change neuronal pathways and cause addictive behaviour. But glutathione can reduce oxidative stress and therefore decrease the development of addiction (46). 

NAC is included in Optimal Antiox, along with a number of other antioxidants and nutients that can help you overcome addiction and manage withdrawal.

6. Vitamin D

Vitamin D is a fat-soluble vitamin that our skin synthesizes when exposed to the sun.

Every tissue in your body has vitamin D receptors, including the brain, heart, muscles, and immune system.

This means your entire body needs it to function properly and a deficiency can lead to costly physiological and psychological consequences, including addiction.

Researchers have concluded that chronic vitamin D deficiency is an environmental factor contributing to drug use. And supplementation should be considered for the effective treatment of drug abuse and addiction (51-54). 

Other studies have discovered that:

• Vitamin D protects against the dopamine-depleting effects of methamphetamine (52-54);

• There is also a positive association between vitamin D deficiency and severity of alcohol-use disorders (55); and

• Patients prescribed narcotic pain medication – such as morphine, fentanyl or oxycodone – end up having to take higher doses if they are deficient in vitamin D (56).

I take a Vitamin D supplement every day to optimize my levels.

It's important to test and monitor your Vitamin D levels before and after supplementing with it.

7. Magnesium

Magnesium is a vital mineral that participates in more than 300 biochemical reactions in the body. This includes neurotransmitter and hormonal activity, both of which can have a huge effect on your mood and brain function.

Magnesium is one of the three nutrients that I think everyone should be taking for their brain, as most people are deficient.

The mineral has been shown to decrease dependence on opiates, nicotine, cocaine, amphetamine and alcohol, and reduce the intensity of withdrawal symptoms when stopping these drugs (84). 

It can also lower relapse rates, particularly with cocaine and amphetamine addicts (84). 

And researchers have concluded that magnesium supplementation can decrease nicotine addiction in heavy smokers.

It does this by naturally improving the stimulation of the reward system, which reduces the need for stimulation by nicotine or by others addictive substances (85). 

Studies have also found that magnesium deficiency is very common in people dealing with alcohol addiction and withdrawal. And supplementing with magnesium diminishes withdrawal complications, reduces the severity of their withdrawal symptoms, and lowers their need for anti-anxiety medication (86, 87). 

Foods that contain magnesium include spinach, chard, pumpkin seeds, almonds, avocado, dark chocolate and bananas. 

These foods are included in my Free Grocery Shopping Guide for Optimal Brain and Mental Health.

But supplementation or taking Epsom salt baths is still necessary for most people because magnesium is rapidly used up during times of stress and certain psychiatric drugs can deplete magnesium. 

Magnesium is included in this supplement.

8. Zinc

Zinc is an essential mineral for mental health, especially if you struggle with chronic anxiety. 

It can also help treat addiction and withdrawal. 

Excessive urinary excretion of zinc and zinc deficiency have been found in drug addicts. And researchers recommend zinc supplementation to treat addiction and reduce withdrawal symptoms (70, 71). 

Research shows that opioid users have lower levels of zinc (72-75). 

And in the case of alcoholism, alcohol is known to deplete zinc from the body. Over time, chronic alcohol consumption can produce a downward spiral in which zinc deficiency causes chronic stress, driving a person to drink more alcohol, which further depletes zinc and causes more anxiety in the long run.

In animals, zinc reduces the intensity of morphine dependence, and zinc chelators worsen withdrawal symptoms (76, 77, 78). 

Some of the best food sources of zinc include oysters, grass-fed beef, pumpkin seeds, cashews, mushrooms and spinach.

These foods are included in my Free Grocery Shopping Guide for Optimal Brain and Mental Health.  

However, I still recommend at least short-term zinc supplementation to ensure you get enough.

I created and take the Optimal Zinc supplement for that reason.

9. Vitamin C

It might seem unbelievable but there is research demonstrating vitamin C’s usefulness in overcoming addiction and reducing withdrawal symptoms. 

First of all, vitamin C levels are significantly lower in drug addicts (68). 

And high doses of vitamin C have been shown to increase endorphin levels, decrease opioid use, and reduce the withdrawal syndrome of heroin addicts (58). 

The chronic administration of vitamin C can also prevent the development of tolerance and physical dependence on morphine (59, 69). 

When I weened off psychiatric medication, I took large doses of vitamin C every day. By large doses, I mean about 10 grams spread throughout the day. I noticed it reduced stress and helped calm me down. 

Various studies show that vitamin C reduces stress and anxiety and decreases the severity of depression (62-67). 

And other research shows that long-term vitamin C deficiency contributes to nervousness and emotional instability. And there was a 35% reduction in mood disturbance in hospitalized patients after vitamin C treatment (60, 61). 

Foods that contain vitamin C include green peppers, citrus fruits, tomatoes, cauliflower, Brussels sprouts, broccoli, and cabbage. These foods are included in my Free Grocery Shopping Guide for Optimal Brain and Mental Health.

But it’s best to supplement with it. That way, you know you’re getting enough.

Vitamin C is included in this supplement.

Others

Here are some other nutritional supplements to consider. Based on my research and experience, these nutrients can help manage addiction and withdrawal, but they aren’t as effective as the other ones above and/or there is less research to support their use:

• Lithium Orotate (79)

• Taurine (80)

• B Vitamins (82)

• Glutamine (83)

• DL-Phenylalanine (DLPA) (81) – I almost included this one in the main list because it has really helped me, but there isn’t too much research on it. I originally wrote about it here.

• D-Serine/Sarcosine (88-95)

Conclusion

Just like mental illness, you can beat addiction. They often go hand in hand.

I’ve learned with time, and with the proper information and resources, people can snap out of their addiction cycle and be happy and calm with themselves without mind-altering drugs and habits. 

You may feel like you have no other choice, but you do. You can get on with your life without addictive substances.

Overall, I really believe in the power of these nutrients for tackling addiction and minimizing withdrawal symptoms:

• Citicoline

• Theanine

• Krill Oil

• ALCAR

• NAC

• Vitamin D

• Magnesium

• Zinc

• Vitamin C

Taking a combination of them can make the transition to sobriety much easier. 

I’ve experienced the benefits of them firsthand, and I hope you do too.

Enjoy This Article? You Might Also Like My FREE Food Guide for Optimal Brain and Mental Health!

CLICK HERE TO DOWNLOAD THE FREE GUIDE

Live Optimally,

Jordan Fallis

Connect with me

References:

(1) http://www.ncbi.nlm.nih.gov/pubmed/23538074

(2) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695184/

(3) http://www.ncbi.nlm.nih.gov/pubmed/11796739

(4) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1430829/

(5) https://www.ncbi.nlm.nih.gov/pubmed/1839138

(6) https://www.ncbi.nlm.nih.gov/pubmed/1098982

(7) http://www.ncbi.nlm.nih.gov/pubmed/19351232

(8) https://www.ncbi.nlm.nih.gov/pubmed/10102764

(9) https://www.ncbi.nlm.nih.gov/pubmed/17873684

(10) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139283/

(11) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011061/

(12) https://www.ncbi.nlm.nih.gov/pubmed/16055952

(13) https://www.ncbi.nlm.nih.gov/pubmed/18296328

(14) https://www.ncbi.nlm.nih.gov/pubmed/21735551

(15) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560823/

(16) https://www.ncbi.nlm.nih.gov/pubmed/23233221

(17) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754842/

(18) http://ajcn.nutrition.org/content/71/1/179S.long

(19) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618203/

(20) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC533861/

(21) http://www.ncbi.nlm.nih.gov/pubmed/12777162

(22) https://www.ncbi.nlm.nih.gov/pubmed/18060675

(23) https://www.ncbi.nlm.nih.gov/pubmed/12414556

(24) https://www.ncbi.nlm.nih.gov/pubmed/16131851

(25) https://www.ncbi.nlm.nih.gov/pubmed/26570994

(26) https://www.sciencedaily.com/releases/2014/11/141106101903.htm

(27) http://jop.sagepub.com/content/28/8/804

(28) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804563/

(29) https://www.ncbi.nlm.nih.gov/pubmed/14500111

(30) https://www.ncbi.nlm.nih.gov/pubmed/23390041

(31) http://newsinfo.iu.edu/web/page/normal/18785.html

(32) http://www.ncbi.nlm.nih.gov/pubmed/18440072

(33) http://www.ncbi.nlm.nih.gov/pubmed/18996163  

(34) http://www.ncbi.nlm.nih.gov/pubmed/18225476

(35) http://www.ncbi.nlm.nih.gov/pubmed/16449100/

(36) http://www.ncbi.nlm.nih.gov/pubmed/17606664/

(37) http://www.ncbi.nlm.nih.gov/pubmed/17113207/

(38) http://www.ncbi.nlm.nih.gov/pubmed/19103434

(39) http://www.ncbi.nlm.nih.gov/pubmed/19103434/

(40) http://www.ncbi.nlm.nih.gov/pubmed/17445781

(41) http://www.ncbi.nlm.nih.gov/pubmed/19581567

(42) http://www.ncbi.nlm.nih.gov/pubmed/26975440

(43) https://www.ncbi.nlm.nih.gov/pubmed/20163391  

(44) http://www.ncbi.nlm.nih.gov/pubmed/24676047

(45) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009342/

(46) https://www.ncbi.nlm.nih.gov/pubmed/26809999

(47) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455547/

(48) https://www.ncbi.nlm.nih.gov/pubmed/20595193

(49) https://www.ncbi.nlm.nih.gov/pubmed/18978503

(50) https://www.ncbi.nlm.nih.gov/pubmed/10761531

(51) http://eneuro.org/content/3/3/ENEURO.0122-15.2016

(52) http://www.sciencedirect.com/science/article/pii/S2251729413000050

(53) https://www.researchgate.net/publication/257747305_Vitamin_D_as_an_Effective_Treatment_Approach_for_Drug_abuse_and_Addiction

(54) http://connection.ebscohost.com/c/articles/89120175/vitamin-d-as-effective-treatment-approach-drug-abuse-addiction

(55) https://www.ncbi.nlm.nih.gov/pubmed/23916323

(56) https://www.sciencedaily.com/releases/2009/03/090320112114.htm

(57) https://www.ncbi.nlm.nih.gov/pubmed/21448659

(58) https://www.ncbi.nlm.nih.gov/pubmed/10836211

(59) http://pubmedcentralcanada.ca/pmcc/articles/PMC4166050/

(60) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727637/

(61) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599706/

(62) http://www.ncbi.nlm.nih.gov/pubmed/26353411

(63) http://www.ncbi.nlm.nih.gov/pubmed/24511708

(64) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599706/

(65) http://www.ncbi.nlm.nih.gov/pubmed/12208645

(66) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376513/

(67) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376513/

(68) https://www.ncbi.nlm.nih.gov/pubmed/11641753

(69) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852062/

(70) https://www.ncbi.nlm.nih.gov/pubmed/7599515

(71) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523930/

(72) http://www.ncbi.nlm.nih.gov/pubmed/11199888

(73) http://www.ncbi.nlm.nih.gov/pubmed/8886315

(74) http://www.ncbi.nlm.nih.gov/pubmed/2374368

(75) http://www.ncbi.nlm.nih.gov/pubmed/6129905

(76) http://www.ncbi.nlm.nih.gov/pubmed/11068022

(77) http://www.ncbi.nlm.nih.gov/pubmed/18389791

(78) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523930/

(79) https://www.ncbi.nlm.nih.gov/pubmed/3718672

(80) https://www.ncbi.nlm.nih.gov/pubmed/23392920

(81) https://www.ncbi.nlm.nih.gov/pubmed/22397264

(82) https://www.ncbi.nlm.nih.gov/pubmed/9719389

(83) http://hams.cc/glutamine/

(84) https://www.ncbi.nlm.nih.gov/pubmed/18557129

(85) http://www.omicsonline.org/magnesium-and-zinc-involvement-in-tobacco-addiction-2155-6105.S2-005.pdf

(86) https://www.ncbi.nlm.nih.gov/pubmed/1844558

(87) https://www.ncbi.nlm.nih.gov/pubmed/3577989

(88) https://www.ncbi.nlm.nih.gov/pubmed/21106609

(89) https://www.ncbi.nlm.nih.gov/pubmed/25801502

(90) https://www.ncbi.nlm.nih.gov/pubmed/26861675

(91) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100571/

(92) https://www.ncbi.nlm.nih.gov/pubmed/23518710

(93) https://www.ncbi.nlm.nih.gov/pubmed/19595781

(94) https://www.ncbi.nlm.nih.gov/pubmed/20541592

(95) https://www.ncbi.nlm.nih.gov/pubmed/22728761

(96) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851068/

(97) https://www.amazon.com/Food-Behavior-Barbara-Reed-Stitt/dp/0939956098

(98) https://www.amazon.com/Addictions-Nutritional-Approach-John-Finnegan/dp/092742505X

(99) https://www.amazon.ca/Biochemical-Individuality-Roger-Williams/dp/0879838930

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The Brain and Mental Health Benefits of Low-Level Laser Therapy (LLLT) & Photobiomodulation

Low-level laser/light therapy (LLLT) is an important treatment that I have used over the years to support my brain after serious concussions, toxic mold exposure and multiple psychiatric prescriptions. 

And in my experience, it is one of the most efficient ways to boost brain function and improve mental health. 

Yet your doctor likely has no idea what it is. 

It’s about as cutting-edge as it gets, and even more unconventional than neurofeedback. But it works. 

Also known as photobiomodulation, LLLT is the application of low-power lasers or light-emitting diodes (LEDs) to the body for therapeutic purposes.  When LLLT is applied to the brain, it is known as transcranial LLLT or transcranial photobiomodulation (44). 

LLLT has been around since 1967, and there are now more than four thousand scientific studies showing that it can help treat a variety of disorders without any harmful effects. Unlike high-intensity surgical lasers, low-powered lasers do not cut or burn tissue. Instead, these lasers stimulate a biological response and encourage cells to function properly (11, 12, 33). 

And luckily, it’s very easy to treat yourself at home with LLLT using red and infrared light.

I have used three main devices on my brain. They significantly improved the quality of my life over the years.

Make sure you read the Recommended Devices section below, where I discuss the different devices I have used. 

How It Works

Research shows that red and infrared light between the wavelengths of 632 nanometers (nm) and 1064 nm produce positive biological effects. For brain cells, the optimal range appears to be between 800 nm and 1000 nm, as these wavelengths can penetrate the scalp and skull and reach the brain (19, 20, 25-31).

The devices I have used fall within this range. 

The light emitted from the devices below stimulate a photochemical reaction within cells, which can accelerate the natural healing process and cause beneficial changes in behaviour (45).

How does it do this?

Mainly by supporting your mitochondria. 

As I’ve discussed before, mitochondria are considered the “powerhouses of the cell,” generating most of the energy in your body in the form of adenosine-5’- triphosphate (ATP). 

ATP is your body’s main source of cellular fuel. You are constantly using it, and your brain needs enough of it to work properly. 

Proper mitochondrial function and ATP production is critical for neuroprotection, cognitive enhancement, and the prevention and alleviation of several neurological and mental disorders (46).

And research demonstrates that transcranial LLLT supports mitochondrial function and significantly increases the production of ATP in the brain (3-5, 8-10, 13-17, 21-22, 34, 45).

Your mitochondria contain photoacceptors that absorb the photons from light and convert them into ATP – energy that can be used to perform cellular tasks and biological processes (39, 40).

This process is comparable to plant photosynthesis, during which sunlight is absorbed by plants and converted to energy for the plants to grow (23, 24). 

By stimulating the mitochondria and producing more ATP, LLLT gives brain cells extra ATP energy to work better and heal and repair themselves.

On top of this, LLLT has also been shown to:

• Increase neurogenesis, brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) (1, 41, 42)

• Reduce inflammation (1, 35, 37, 41)

• Decrease free radicals and oxidative stress in the brain (2)

• Increase blood flow and circulation, including within the frontal cortex (6, 18, 32)

• Reduce pain by increasing our body’s endorphins (natural opioids and natural pain relievers) (7, 36)

• Increased rate of oxygen consumption in the frontal cortex (32, 100)

• Increase serotonin (38)

My Experience and What You Should Expect

LLLT is one of the most impactful and helpful actions I took to optimize my brain and mental health.

By the time I was off all psychiatric medications, I had lost a lot of my full cognitive capabilities. Thankfully, LLLT helped restore them.

Here are some of the results I noticed:

• Increased cognitive function

• Sharper thinking

• Improved mood, concentration, alertness

• Less fatigue and reduced need for sleep

• More mental motivation, endurance and productivity

Overall, it improved my mental constitution. I didn’t get as fatigued and worn down as easily and I could focus and think harder for longer periods of time.

LLLT also has a cumulative effect. Your brain becomes stronger and more resilient over time as you do the treatment consistently.  

It allowed me to reduce the number of supplements I was taking daily. I now realize that I needed the treatment for many years, but I just didn’t know it existed.

Luckily, I started treating myself on a regular basis and have never felt better. 

Many serious brain injuries and mental illnesses can be successfully treated with LLLT, including depression, anxiety, post-traumatic stress disorder, traumatic brain injury, post-concussion syndrome, stroke and Alzheimer's disease.

I explore how LLLT has been shown to help each of these disorders below. Feel free to skip to the disorder you're struggling with to learn more.

Depression and Anxiety

Studies in rats and humans provide evidence that LLLT improves mood and decreases depressive symptoms.

In 2009, researchers took 10 patients with a history of major depression and anxiety (including post-traumatic stress disorder and substance abuse) and applied LLLT to their foreheads for four weeks. At the end of the study, six of the 10 patients experienced a remission of their depression, and seven of the 10 patients experienced a remission of their anxiety. There were no observable side effects (54). 

“The data supports that LLLT to the head constitutes a promising neurotherapeutic tool to modulate behaviour in a non-invasive manner.”

— Dr. Julio C. Rojas, MD, PhD, University of California

This makes sense considering that several studies show that depression is linked to abnormal blood flow in the frontal cortex of the brain, and LLLT increases blood flow and circulation (47, 53). 

Other studies have shown that participants report a significant increase in positive emotions and a reduction in depressive symptoms for two weeks after LLLT treatment (55-57). 

Sufferers of traumatic brain injury (TBI) also experience a decrease in depression, anxiety, irritability and insomnia, and an overall improvement in quality of life, because of LLLT (58, 59).  

I personally experienced all of these results.

Traumatic Brain Injury

Traumatic brain injury (TBI) is a growing health concern. An estimated 1.7 million people sustain a TBI annually in the U.S. (60). 

Mild TBIs (concussions) make up 75 per cent of all brain injuries. Military personnel deployed to Iraq and Afghanistan frequently experience mild TBI while overseas, and many months after they return home, they often struggle with PTSD, depression and anxiety (61, 62). 

And research shows that transcranial LLLT can help (63). 

I personally experienced this. In 2010, I suffered multiple concussions while living in a moldy home, and thankfully LLLT helped me recover from post-concussion syndrome.

A number of human studies show that patients with chronic mild TBI experience improved cognition, memory and sleep with LLLT treatment. 

One study examined whether LLLT could help 11 patients with chronic mild TBI symptoms. They all had cognitive dysfunction, and four of them had multiple concussions like I did. 

After 18 LLLT sessions, their cognition, memory and verbal learning improved. Participants also said they slept better and had fewer PTSD symptoms. Coworkers, friends and family reported improved social, interpersonal, and occupational functioning (65). 

If LLLT was a drug, we would definitely be hearing about it.

In another study, 10 people with chronic TBI were given 10 treatments of LLLT (810 nm) and witnessed a reduction in headaches, cognitive dysfunction, sleep problems, anxiety, depression and irritability (66). 

There have also been a few case studies showing beneficial effects of transcranial LLLT in TBI patients (67, 68):

“Seven years after closed-head TBI from a motor vehicle accident, case 1 (a 66-year-old woman) began transcranial LED treatments. Before LLLT treatment, she could focus on her computer for only 20 minutes. After eight weekly LLLT treatments, her focused computer time increased to 3 hours. She has treated herself nightly at home for 5.5 years now and maintains her improved cognition at age 72 years.”

“Case 2 (a 52-year-old retired, high-ranking female military officer) had a history of multiple closed-head injuries. Before beginning LLLT treatments, she was on medical disability for 5 months. After 4 months of nightly LLLT treatments at home, she returned to working full-time as an executive consultant with an international technology consulting firm and discontinued medical disability. Neuropsychological testing performed after 9 months of transcranial LED showed significant improvement in cognition and memory, as well as reduction in post-traumatic stress disorder symptoms.”

“Case 3 received 20 LLLT treatments over two months and experienced highly favourable outcomes with decreased depression, anxiety, headache, and insomnia, whereas cognition and quality of life improved.”

So LLLT can improve cognition, reduce costs in TBI treatment and be applied at home?

Hmm, sounds like something the pharmaceutical industry would not like people to know about – and something that would force them to lose a lot of life-long customers. 

Several mouse studies also show that transcranial LLLT can prevent cell death and increase neurological performance after TBI (69-72). 

Researchers believe that LLLT works so well for people struggling with TBI symptoms because mitochondria in the brain are significantly dysfunctional after TBI, resulting in an inadequate supply of ATP, and LLLT can support the mitochondria and increase ATP production (73-75, 79). 

There is also poor blood flow and oxygenation, and increased inflammation and oxidative stress in the brain after head injuries. This contributes to brain damage, but LLLT can help combat these problems, increase antioxidants, promote neurogenesis and relieve chronic symptoms (76-78, 80-83).

Alzheimer's Disease and Cognitive Impairment

Research shows that LLLT can boost performance and improve cognitive function, including attention and memory, in elderly people, young healthy people and animals.  

Preliminary studies demonstrate that LLLT could slow down the progression of Alzheimer’s disease by decreasing a protein in the brain that is linked to dementia (84-86, 94). 

Downregulation of brain-derived neurotrophic factor (BDNF) occurs early in the progression of Alzheimer's disease, and LLLT has been shown to prevent brain cell loss by upregulating BDNF (87). 

“LLLT could be used as a preventive intervention in people who present risk factors for Alzheimer’s disease, mild cognitive impairment, or a history of head trauma. In such patients, LLLT could be combined with cognitive intervention approaches.”

— Dr. Francisco Gonzalez-Lima, PhD, University of Austin, Texas

Researchers have also applied LLLT to middle-aged mice, and discovered that the memory and cognitive performance of the middle-aged mice improved so much that it was comparable with that of young mice. The researchers concluded that LLLT should be “applied in cases of general cognitive impairment in elderly persons” (5, 88). 

Several others studies have shown that LLLT significantly increases alertness, awareness and sustained attention, and improves short-term memory and reaction time. Study participants also made fewer errors during tasks and tests (89-91, 93, 95). 

Another study found that LLLT was just as effective as exercise at enhancing cognition, likely by providing neuroprotection and supporting the mitochondria (92, 96).

Stroke

Multiple studies show that LLLT can significantly reduce brain damage and improve recovery outcomes after a stroke (110-113). 

In one study, researchers applied LLLT over the entire surface of the head of stroke patients approximately 18 hours after a stroke. Five days after the stroke, they found significantly greater improvements in the LLLT-treated group. The improvements continued 90 days after the stroke. At the end of the study, 70% of the patients treated with real LLLT had a successful outcome compared with only 51% of the control subjects (114). 

Follow up studies with over 600 stroke patients found similar beneficial results. Researchers believe increase in the production of ATP is responsible for the improvements (115, 116, 117).  

Numerous studies also show that LLLT significantly reduces neurological problems and improves behaviour in rats and rabbits after stroke. It also increases the growth of new brain cells in these animals, improving their overall recovery (118-124).

Other Disorders

There are a number of other disorders that can also improve with LLLT treatment: 

• Parkinson’s disease (PD) – “Mitochondria in PD tissues are compromised, and LLLT could be developed as a novel treatment to improve neuronal function in patients with PD” (109).

• Amyotrophic lateral sclerosis (ALS) - Mitochondrial dysfunction and oxidative stress play an important role in motor neuron loss in ALS. Motor function significantly improved with LLLT in a group of people in the early stage of the disease (99).

• Autism – Linked to mitochondria dysfunction and inflammation, so LLLT would likely help (103, 104).

• Bipolar disorder – Linked to mitochondria dysfunction and inflammation (105, 106, 107)

• Schizophrenia – Linked to mitochondria dysfunction and inflammation (105, 106)

• Smoking Cessation – Check out this video.

• Alcoholism (101, 102)

• Opiate addiction (102)

• Headaches and migraines (108)

• Acne - This is unrelated to brain health but LLLT can also treat acne. Improving my diet helped me overcome my acne many years ago, but I definitely wish I had known about LLLT when I had it. An integrative physician I know has had a lot of success with her patients struggling with acne and other skin issues (97, 98).

Recommended Devices

I first discovered LLLT when reading Dr. Norman Doidge’s book, The Brain's Way of Healing: Remarkable Discoveries and Recoveries from the Frontiers of Neuroplasticity.

Dr. Doidge talks about the BioFlex Laser Therapy equipment, which costs tens of thousands of dollars.

I found an integrative physician who owned a Bioflex and I gave it a try. 

After a few sessions, I started experiencing beneficial effects.

So I decided to go ahead and buy my own LLLT devices for much cheaper.

I ended up finding and trying a number of different LLLT devices myself

They were much less expensive than the Bioflex, and I wanted to see how they compared to the Bioflex.

Many of the devices I bought didn't help me very much because they weren't powerful enough.

Most light devices aren't very effective at penetrating the skull.

But after a lot of research, and trial and error, I found devices that were powerful enough.

And they did help me.

And they provided me with the same brain and mental health benefits as the expensive Bioflex.

Here are the three devices I now recommend because they actually work:

• Optimal 1000 Brain Photobiomodulation Therapy Light (Combo Red/NIR) - This is a powerful device that shines 660 nm of red light and 850 nm of infrared light. Like I have, you can shine it on your forehead for 5 minutes every day. You can also shine it on other parts of your head and on your entire body, including on your thyroid, thymus gland and gut. I have experienced incredible benefits from doing this.

• Optimal 300 Brain Photobiomodulation Therapy Light (Combo Red/NIR) - This is a smaller and more convenient device that I have taken with me when travelling.

• Vielight Neuro Duo – This is a transcranial-intranasal headset with 810 nm of near infrared light. It penetrates deeper into brain tissue and is absorbed better by the central nervous system. If you decide to get this one, you can use the coupon code JORDANFALLIS for a 10% discount. Some research has shown a 20-fold higher efficiency of light delivery to the deep brain through the nose instead of transcranial application (125). Vielight has several different devices and you can also use the coupon code JORDANFALLIS for 10% off any of them.

Unlike most pharmaceuticals, LLLT is very safe, non-toxic and non-invasive, so you can easily try it on yourself without concern and see if it helps you like it has helped me (33, 34, 126). 

You can shine the light all over your head. But start slow and apply the light to different areas of your head for just 1-2 minutes, maybe even less if you’re really sensitive. Then work your way up to longer periods of time, perhaps 5-10 minutes per area. There’s no exact proper way to do this. Listen to your body and see how it affects you. 

It’s important to note that some people experience grogginess and fatigue after using LLLT. I experienced this the day after my first treatment. I was incredibly tired and lethargic. This was a sign that I did too much. 

If you feel extremely tired immediately after LLLT or the next day, take a break and do less next time. For example, if you applied light to your forehead for 3 minutes, then drop back down to 2 minutes for your next session. 

It is also important to cycle LLLT. The way it works is similar to exercise, so you need to take breaks in order to heal and get stronger. Using it everyday can cause a burnout effect. You can use it every other day to give your brain a chance to recover.

More Details on How I’ve Used the Optimal 1000 Therapy Light

Someone recently asked me for more details on how to use the Optimal 1000 Brain Photobiomodulation Therapy Light (Combo Red/NIR). So I thought I’d share what I told them here:

I usually hang the Optimal 1000 Brain Photobiomodulation Therapy Light (Combo Red/NIR) on my door, and then start by standing in front of it for about 10 minutes. I would say I'm about 1 or 2 feet away so that the light is shining on most of my body. I tend to prioritize my upper body though, particularly my thyroid, gut, thymus gland, and of course my head. But what I've found is that shining it on other parts of your body (besides my brain) actually leads to indirect cognitive benefits as well. So it's not just shining it on the brain that helps with cognitive function.

I will also sometimes turn my back to the light and shine it on my back and spine area, and on the back of my head, for about 5 to 10 minutes.

I also get much closer (perhaps about 2-3 inches away) and shine it just on my forehead for 4-5 minutes or so. It is safe to do this because our devices emit a very low, safe level of EMFs.

So what I usually do is 10 minutes on my entire body and then right after that, 5 minutes on my face/forehead. But it's completely fine to do them separately at different times of the day or on completely separate days if you want.

It's usually good to limit your exposure to a maximum of 20 minutes at a time though, because too much at one time can make you too tired and negate the beneficial effects.

The back of your head where your spine meets your skull is another great area to shine the light. I also like to shine the light on the sides of my head (around my ears) for a few minutes each.

Conclusion

Frankly, it’s ridiculous that this therapy is not more well-known and promoted by doctors. But like everything else on this website, you don’t have to wait for conventional medicine to catch up, and you can experiment with the LLLT devices yourself. There is a high benefit-to-risk ratio. 

I suspect that home-use application of LLLT will become much more popular in the coming years.

The remarkable effects of the treatment in healing the brain in a non-invasive manner, along with the fact that there is little evidence of any adverse side effects, suggests to me that it’s use will only increase.

At the same time, distrust in pharmaceuticals continues to grow because of uncertain efficacy and unbearable side effects. 

And as the Western population continues to age, the incidence of the degenerative brain diseases will only continue to increase, which will produce a severe financial and societal burden.

So people will realize they are at a disadvantage by not having their own device(s) and will start using them on a regular basis for optimal mental health and cognition.

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Live Optimally,

Jordan Fallis

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References:

(1) http://www.ncbi.nlm.nih.gov/pubmed/23003120

(2) http://www.ncbi.nlm.nih.gov/pubmed/23281261

(3) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945284/

(4) http://www.ncbi.http://www.ncbi.nlm.nih.gov/pubmed/21274733lm.nih.gov/pubmed/21274733

(5) http://www.http://www.ncbi.nlm.nih.gov/pubmed/22850314.nlm.nih.gov/pubmed/22850314

(6) http://www.ncbi.nlm.nih.gov/pubmed/15954817

(7) http://onlinelibrary.wiley.com/doi/10.1002/lsm.20583/abstract

(8) http://www.ncbi.nlm.nih.gov/pubmed/9421973

(9) http://www.ncbi.nlm.nih.gov/pubmed/11959421

(10) http://www.ncbi.nlm.nih.gov/pubmed/17603858

(11) http://www.ncbi.nlm.nih.gov/pubmed/5098661  

(12) http://www.ncbi.nlm.nih.gov/pubmed/4659882

(13) http://www.ncbi.nlm.nih.gov/pubmed/10365442/

(14) http://www.ncbi.nlm.nih.gov/pubmed/6479342/ 

(15) http://www.ncbi.nlm.nih.gov/pubmed/2476986/

(16) http://www.ncbi.nlm.nih.gov/pubmed/17463313/

(17) http://www.ncbi.nlm.nih.gov/pubmed/19837048/

(18) http://www.ncbi.nlm.nih.gov/pubmed/19995444/

(19) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442599/

(20) http://www.sciencedirect.com/science/article/pii/S0004951414601276

(21) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288797/

(22) http://www.ncbi.nlm.nih.gov/pubmed/23239434?dopt=AbstractPlus

(23) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953713/

(24) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065857/

(25) https://www.ncbi.nlm.nih.gov/pubmed/26535475

(26) https://www.ncbi.nlm.nih.gov/pubmed/26347062

(27) https://www.ncbi.nlm.nih.gov/pubmed/24568233

(28) https://www.ncbi.nlm.nih.gov/pubmed/21182447

(29) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796659/

(30) http://stroke.ahajournals.org/content/40/4/1359.long

(31) https://www.ncbi.nlm.nih.gov/pubmed/17463313

(32) http://www.medscape.com/viewarticle/775815

(33) https://www.psio.com/pdf/LLLT-of-eye-and-brain.pdf

(34) http://www.ncbi.nlm.nih.gov/pubmed/6200808

(35) http://www.ncbi.nlm.nih.gov/pubmed/22275301

(36) http://www.ncbi.nlm.nih.gov/pubmed/17439348

(37) http://www.ncbi.nlm.nih.gov/pubmed/17868110

(38) http://www.ncbi.nlm.nih.gov/pubmed/26202374

(39) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288797/

(40) http://www.isabelleverbeek.nl/wp-content/uploads/2014/05/A2-cognitie-Gonzalez-softlaser-fotonen-therapie-2014b.pdf

(41) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065857/

(42) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538543/

(43)https://www.researchgate.net/publication/273781132_Red_and_NIR_light_dosimetry_in_the_human_deep_brain

(44) http://www.ncbi.nlm.nih.gov/pubmed/25772014

(45) http://www.ncbi.nlm.nih.gov/pubmed/19837048

(46) http://www.sciencedirect.com/science/article/pii/S0006295213007417

(47) http://www.ncbi.nlm.nih.gov/pubmed/15025051

(48) http://www.ncbi.nlm.nih.gov/pubmed/16043128

(49) http://www.ncbi.nlm.nih.gov/pubmed/12946880

(50) http://www.ncbi.nlm.nih.gov/pubmed/15061044

(51) http://www.ncbi.nlm.nih.gov/pubmed/15570642

(52) http://www.ncbi.nlm.nih.gov/pubmed/12181629

(53) http://www.ncbi.nlm.nih.gov/pubmed/10739143

(54) http://www.ncbi.nlm.nih.gov/pubmed/19995444

(55) https://www.ncbi.nlm.nih.gov/pubmed/27267860

(56) http://dose-response.org/wp-content/uploads/2014/06/Gonzalez-Lima_2014.pdf

(57) https://www.ncbi.nlm.nih.gov/pubmed/23200785

(58) https://www.ncbi.nlm.nih.gov/pubmed/26535475

(59) https://www.ncbi.nlm.nih.gov/pubmed/26347062

(60) https://www.cdc.gov/traumaticbraininjury/pdf/bluebook_factsheet-a.pdf

(61) http://www.ncbi.nlm.nih.gov/pubmed/18234750/

(62) https://www.cdc.gov/traumaticbraininjury/pdf/mtbireport-a.pdf

(63) http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0053454

(65) https://www.ncbi.nlm.nih.gov/pubmed/24568233

(66) https://www.ncbi.nlm.nih.gov/pubmed/26347062

(67) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104287/

(68) https://www.ncbi.nlm.nih.gov/pubmed/26535475

(69) http://www.ncbi.nlm.nih.gov/pubmed/17439348/

(70) http://www.ncbi.nlm.nih.gov/pubmed/19800810/

(71) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538543/

(72) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397203

(73) http://www.ncbi.nlm.nih.gov/pubmed/11059663

(74) http://www.ncbi.nlm.nih.gov/pubmed/19637966

(75) http://www.ncbi.nlm.nih.gov/pubmed/16120426

(76) http://www.ncbi.nlm.nih.gov/pubmed/18501200/

(77) http://www.ncbi.nlm.nih.gov/pubmed/19995444/

(78) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397203/

(79) http://www.ncbi.nlm.nih.gov/pubmed/17439348/

(80) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397203/

(81) http://www.ncbi.nlm.nih.gov/pubmed/17439348/

(82) http://www.ncbi.nlm.nih.gov/pubmed/17439348

(83)https://www.researchgate.net/publication/229161498_Transcranial_low_level_laser_light_therapy_for_traumatic_brain_injury

(84) http://www.ncbi.nlm.nih.gov/pubmed/18769048/

(85) https://www.researchgate.net/publication/263742704_Low-Level_Laser_Therapy_Ameliorates_Disease_Progression_in_a_Mouse_Model_of_Alzheimer%27s_Disease

(86) http://www.ncbi.nlm.nih.gov/pubmed/24994540

(87) http://www.ncbi.nlm.nih.gov/pubmed/23946409

(88) http://www.ncbi.nlm.nih.gov/pubmed/17855128/

(89) https://www.ncbi.nlm.nih.gov/pubmed/23200785

(90) https://www.ncbi.nlm.nih.gov/pubmed/27080072

(91) https://www.ncbi.nlm.nih.gov/pubmed/26017772

(92) https://www.ncbi.nlm.nih.gov/pubmed/27220529

(93) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953713/

(94) http://www.ncbi.nlm.nih.gov/pubmed/24387311

(95) http://www.sciencedirect.com/science/article/pii/S1074742707001153

(96) http://www.ncbi.nlm.nih.gov/pubmed/23806754

(97) http://www.ncbi.nlm.nih.gov/pubmed/22615511

(98) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352636/

(99) http://www.ncbi.nlm.nih.gov/pubmed/19143012/

(100) https://www.ncbi.nlm.nih.gov/pubmed/26817446

(101) http://www.ncbi.nlm.nih.gov/pubmed/15674998/

(102) http://www.ncbi.nlm.nih.gov/pubmed/19995444

(103) http://www.ucdmc.ucdavis.edu/publish/news/newsroom/8932

(104) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554862/

(105) http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004913

(106) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626880/

(107) http://www.ncbi.nlm.nih.gov/pubmed/23196997

(108) http://www.ncbi.nlm.nih.gov/pubmed/12811613

(109) http://www.ncbi.nlm.nih.gov/pubmed/19534794/

(110) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538543/

(111) http://www.ncbi.nlm.nih.gov/pubmed/19995444

(112) http://www.ncbi.nlm.nih.gov/pubmed/17463313/

(113) http://www.ncbi.nlm.nih.gov/pubmed/19233936/

(114) http://www.ncbi.nlm.nih.gov/pubmed/17463313/

(115) http://www.ncbi.nlm.nih.gov/pubmed/19233936/

(116) http://www.ncbi.nlm.nih.gov/pubmed/20425181/

(117) http://www.ncbi.nlm.nih.gov/pubmed/19837048/     

(118) http://www.ncbi.nlm.nih.gov/pubmed/19995444

(119) http://www.ncbi.nlm.nih.gov/pubmed/16946145/

(120) http://www.ncbi.nlm.nih.gov/pubmed/17693028/

(121) http://www.ncbi.nlm.nih.gov/pubmed/17678491/

(122) http://www.ncbi.nlm.nih.gov/pubmed/16444697/  

(123) http://www.ncbi.nlm.nih.gov/pubmed/17693028

(124) http://www.ncbi.nlm.nih.gov/pubmed/15155955

(125)https://www.researchgate.net/publication/273781132_Red_and_NIR_light_dosimetry_in_the_human_deep_brain

(126) http://www.ncbi.nlm.nih.gov/pubmed/23675984

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20 Proven Ways to Quickly Lower Your Cortisol Levels

Chronic stress is killer. 

It broke me down over the years and led me to deep depression.

Getting a handle on it has been critical to my recovery. 

But it took me a while to figure out what works.

And I’d rather not see other people struggle and frantically look for solutions.

So I’ve gathered some of my favourite ways to quickly lower levels of cortisol, your body’s main stress hormone.

But before we get to them, let’s quickly discuss cortisol and how chronically high levels of cortisol can negatively affect your brain and mental health. 

How Stress and Cortisol Affect Your Brain

Cortisol is known as the “stress hormone”.

It’s a naturally-occurring steroid hormone that’s produced by your adrenal glands and released when you’re under physical or mental stress. Essentially, it triggers our fight-or-flight response in stressful situations.

But it’s also absolutely necessary for our health, as it plays a key role in many different bodily processes. 

Cortisol levels are generally highest in the morning and lowest at night. But problems can arise when they are elevated for prolonged periods of time (134). 

Chronically high cortisol levels can:

• Change the size, structure and functioning of your brain;

• Shrink and kill brain cells;

• Cause premature aging in the brain;

• Contribute to memory loss and lack of concentration;

• Slow down our ability to grow new brain cells; and

• Increase inflammation in the brain (135-140).

Watch this TED-Ed video, “How Stress and Cortisol Affect Your Brain,” to learn more: 

Chronic stress and high levels of cortisol also increase activity in the amygdala, the fear centre of the brain. This can create a vicious cycle in which the brain is more likely be get stuck in a constant state of fight-or-flight.

When I did neurofeedback, my practitioner discovered my amygdala was overactive. She trained it back down to normal levels, and my chronic anxiety dissipated.

Anxiety isn’t the only mental condition linked to an abnormal stress response. Here are some others:

• Major depressive disorder;

• Bipolar disorder;

• Borderline personality disorder;

• Insomnia;

• ADHD;

• Anorexia;

• Bulimia;

• Alcoholism; and

• Dementia and cognitive impairment (135-150).

Luckily, there are a number of ways to manage and overcome chronic stress, lower cortisol levels, reverse damage done to the brain, and improve your sense of wellbeing. 

This article includes the best foods, nutrients, herbs and supplements that reduce cortisol; as well as the best lifestyle habits, therapies and practices that reduce cortisol.

Let’s go through them.  

The Best Foods, Nutrients, Herbs and Supplements To Naturally Lower Cortisol Levels

1. Eat Dark Chocolate

Most people know that dark chocolate is rich in multiple antioxidants, such as flavonols and polyphenols, which reduce oxidative stress.

But it also reduces cortisol. 

This may explain why people love to eat chocolate and experience relaxation when they do. 

Dark chocolate can protect your brain by boosting BDNF, your brain’s growth hormone. 

You should always try to get raw dark chocolate with the least amount of sugar.

2. Drink Tea

Several different types of tea have beneficial effects on cortisol levels. 

Green tea has been shown to inhibit the synthesis of cortisol (18). 

And a study found that individuals who drank 4 cups of black tea daily for six weeks had lower cortisol levels in comparison to others who didn’t drink black tea (2). 

Researchers couldn’t confirm what caused this reduction in cortisol, but they suspected it had something to do with the high content of theanine, an amino acid found in both black and green tea.

A follow-up study published this year confirmed that theanine can reduce cortisol (13).

Theanine produces a calming effect on the brain by crossing the blood-brain barrier and increasing the production of both GABA and dopamine in the brain (12). 

I personally can’t drink most teas because they tend to contain mycotoxins (mold toxins) and I’m very sensitive to them after living in a moldy home.

If you’ve lived in a moldy home or have found out that you’re genetically susceptible to mycotoxins, you can supplement with straight theanine like I do. 

This supplement includes theanine. 

And if you do decide to drink black tea, you can lower cortisol even more by getting decaffeinated black tea.

Lastly, chamomile tea is another type of tea that can decrease cortisol. It’s been used for centuries as a sleep aid. It contains flavonoids, essential oils, coumarin and other compounds that can help you relax.

Several studies show it can block the precursor hormone of cortisol and improve sleep quality (14, 15). 

This anti-anxiety supplement includes theanine, along with a number of other natural compounds that have helped me manage my stress and anxiety over the years.

3. Eat Extra Virgin Olive Oil

Olive oil has numerous health benefits, particularly because of its strong anti-inflammatory effects.

It also contains a compound called oleuropein, which can reduce cortisol levels (37). 

I add it to my salads and sometimes even take a tablespoon of it straight.

Be careful though. A lot of cheap extra virgin olive oil in grocery stores are not actually “extra virgin.”

Investigations have found that there is a lot of fraud within the olive oil industry and many so-called extra virgin olive oils contains other cheaper, refined vegetable oils, such as soybean, corn and canola. 

This is discussed more in the book Extra Virginity: The Sublime and Scandalous World of Olive Oil. 

4. Take Cortisol-Reducing Nutrients and Herbs

There are a number of nutrients, vitamins, minerals and adaptogenic herbs that have been shown to reduce stress and cortisol levels. 

I’ll go over some of my favourites here.

Phosphatidylserine is probably the best option for reducing stress hormone levels. 

Phosphatidylserine is a fat-soluble amino acid compound that plays a key role in optimal cognitive function. High amounts of phosphatidylserine can be found within the brain, and supplementation has been shown to improve attention and memory, especially in the elderly (114-116). 

“…consumption of phosphatidylserine may reduce the risk of dementia and cognitive dysfunction in the elderly.”

— Food and Drug Administration

On top of all this, phosphatidylserine powerfully lowers cortisol (117-119). 

People who supplement with phosphatidylserine have been shown to have lower average levels of cortisol (120).

I take phosphatidylserine every day. It's part of the Optimal Calm supplement. 

Ashwagandha is another great cortisol-reducing supplement. It’s a popular Indian herb commonly used to prevent anxiety. Its anti-anxiety effect is synergistic with alcohol.

Its stress-reducing effects are likely because it lowers cortisol levels. 

Multiple studies have concluded that it is a potent stress reliever that can reduce cortisol by anywhere from 14 to 32% (121-123). 

Ashwagandha is included in this supplement.

Another adaptogenic herb that can lower cortisol is rhodiola. 

I’ve discussed rhodiola before. It can really help with symptoms of depression. 

Research has found that it may be doing this by significantly reducing stress hormone levels in the body (124-126). 

Lastly, a number of minerals have been shown to reduce cortisol, including zinc, magnesium and selenium (96, 97, 127-133).

That’s why I take and recommend a multi-mineral supplement every day. 

Overall, ashwagandha, rhodiola, phosphatidylserine and minerals are my favourite ways to keep stress levels low, but there are plenty of other supplements that have been shown to positively affect cortisol levels, including:

• Omega-3 Fatty Acids (93, 94)

• N-Acetyl-Cysteine (95)

• Ginseng (98, 99)

• Tribulus (100)

• Bacopa (101)

• Schisandra (102, 103)

• Ginkgo Biloba (104)

• St. John’s Wort (105)

• Lemon Balm (106)

• Holy Basil (107)

5. Consume Enough Food, Protein and Water

Eating enough protein and calories, and drinking enough clean, filtered water is also critical to keeping stress hormone levels low.  

Studies show that severely restricting calories elevates cortisol levels (108, 109). 

Restricting protein and depriving yourself of the amino acid leucine can also stimulate the stress response and increase stress hormones (110). 

That’s why I eat plenty of food each day and supplement with creatine and BCAA protein powder throughout the day when I don’t have access to a source of high-quality protein. 

Lastly, make sure you stay hydrated and drink plenty of water.

Properly-hydrated runners have noticeably lower cortisol levels than dehydrated runners (81).

I use a high-quality filtration system to filter my water so that it’s as pure as possible.

6. Consume More Omega-3s and Less Omega-6s

As I’ve discussed before, omega-3s are dietary fats that are needed for the proper functioning of your brain and nervous system. They improve learning and memory, and protect against psychiatric disorders including depression, mild cognitive impairment, dementia and Alzheimer's disease (4-7). 

Researchers have also found that when individuals supplement with omega-3 fatty acids, there is a significant reduction in the release of cortisol (1, 10).

Omega-3 fatty acids also significantly reduce stress hormones in animals (3). 

Krill oil is my favourite source of omega-3 fatty acids.

I also eat wild salmon and grass-fed beef on a regular basis. 

On the other hand, consuming too many omega-6 fatty acids have been linked to increased inflammation and cortisol levels (8, 9, 11).

So make sure to avoid refined vegetable oils such as soybean, corn, safflower, sunflower, and canola oil.

7. Get Enough Antioxidants

Not only do antioxidants counteract oxidative stress within the body; they can also help reduce cortisol (19, 25). 

Most of the research has been done in athletes, but supplementation with antioxidants – such as berry powders, greens powders, vitamin C, glutathione and CoQ10 – leads to fairly significant reductions in cortisol and other measures of stress (20-23). 

Dark berries in particular contain antochyanins, which have been shown to lower cortisol (24). 

Acai berries are my favourite, as they are loaded with antochyanins and vitamin C.

Regarding vitamin C, the research is mixed on whether it can consistently lower cortisol levels.

However, in my experience, high doses of vitamin C definitely reduce stress.

One study found that a high dose of vitamin C decreases anxiety and improves mood (29). 

After exercise, it’s also been shown to rapidly reduce cortisol (26, 27). 

And multiple other studies have found that both vitamin C and vitamin E reduce cortisol and anxiety (30-32). 

It’s also well known that chronic stress and high cortisol can deplete vitamin C and other antioxidant enzymes (28). 

In addition to getting vitamin C from fruits and vegetables, I take at least 500 mg of supplemental Vitamin C every day. I’ve experimented with taking up to 10 grams daily (2 gram doses throughout the day) and it helped me manage stress, but it’s not necessary unless you find it really helps you. 

Vitamin C and Vitamin E are both included in this supplement, along with several other antioxidant nutrients.

8. Take Curcumin

Curcumin is the most heavily researched compound within turmeric, the spice that gives curry its yellow colour.

Curcumin is one of my favourite compounds for the brain and mental health.

Thousands of high-quality scientific studies have been published, showing that curcumin has anti-inflammatory and antioxidant effects and can increase BDNF, your brain’s growth hormone. 

Research shows that curcumin inhibits the increase in cortisol caused by stress (33, 34). 

And animal studies have found that curcumin may reverse elevated cortisol levels after chronic stress (35, 36). 

Unfortunately, curcumin is very inefficient at absorbing into the bloodstream and reaching the brain (54, 55).

Luckily, science and technology has been able to concentrate significant amounts of curcumin into supplement form and increase its bioavailability. 

I get my curcumin from the Optimal Energy supplement.

Since curcumin is a fat soluble, I take it every day with a fatty meal.

9. Eat Prebiotic Foods

Prebiotics are substances in food that humans can't digest, so they pass through our gastrointestinal tract and promote the growth of many different strains of good bacteria in our lower bowel.

They are essentially food for the probiotics in our intestines.

Dr. Phil Burnet, a neurobiologist at Oxford University, published a paper in 2015 showing that people who ingested prebiotics have lower levels of cortisol.

The people who ingested prebiotics also focused more on positive feedback and less on negative stimuli.

Dr. Burnet said the results were very similar to when people take anti-depressants and anti-anxiety medication, but without the side effects (87).

That’s why I eat prebiotic-rich foods regularly, including sweet potatoes, carrots, onions, asparagus and squash. These foods are included in my free grocery shopping guide for optimal brain health. 

Resistant starch is one of the most potent ways to boost your prebiotic intake. A convenient way to incorporate more of it into your diet is by using and eating potato starch. Other high-quality resistant starches include banana flour, plantain flour and waxy maize. Cooked and cooled white rice and potatoes also contain some resistant starch. 

I previously discussed prebiotics and resistant starch here.

I also created and take Optimal Biotics, which is a premium probiotic supplement that reduces stress and support my mental health. 

10. Limit Alcohol and Caffeine

Excess consumption of alcohol and caffeine have been shown to increase stress hormones, so their consumption should be limited. 

Coffee is definitely good for brain health. There is a lot of research showing it is very healthy and can be protective against dementia. 

However, it can also disrupt sleep and make people anxious. I used to not be able to handle any coffee at all. But now that I'm healthy, I can handle it just fine. I drink one cup of high-quality coffee most mornings.

But if you’re struggling with high cortisol and chronic stress, I wouldn’t recommend high doses of caffeine.

It’s been shown to directly stimulate the adrenal cortex, release cortisol into the bloodstream and increase stress hormone levels (74-76).

One study found that caffeine increased cortisol by 30% in just one hour, and regular consumption can double your cortisol levels (88, 89). 

So limit it as much as possible.

An alternative solution is to consume the whole coffee fruit, instead of drinking coffee.

The coffee fruit doesn’t contain caffeine, but it does contains several healthy compounds not found in coffee beans themselves.

Scientists have discovered that ingesting whole coffee fruit concentrate significantly increases brain function. Coffee fruit concentrate can be found in the Optimal Brain supplement. 

Lastly, excess alcohol consumption over an extended period of time has also been shown to raise cortisol levels. Having a couple drinks here and there likely isn’t a problem though, and you can protect yourself from it by following these steps (90, 91). 

Certain types of alcohol are better to drink than others.

The Best Lifestyle Habits and Practices to Naturally Lower Cortisol Levels

11. Laugh

In the book The Anatomy of an Illness as Perceived by the Patient, Norman Cousins explains how he cured himself of ankylosing spondylitis by laughing along with Marx Brothers movies.

“I made the joyous discovery that ten minutes of genuine belly laughter had an anesthetic effect and would give me at least two hours of pain-free sleep. When the pain-killing effect of the laughter wore off, we would switch on the motion picture projector again and not infrequently, it would lead to another pain-free interval.”

— Norman Cousins

It sounds farfetched, but more and more research is showing that laughter has a powerful effect on our health. 

Researchers have found that laughing and having fun significantly reduces stress hormone levels (65, 66). 

In one study, laughter improved the short-term memory of older adults, and simply anticipating humour decreased their cortisol levels by nearly 50% (64). 

So, next time you’re stressed, try watching a funny TV show or YouTube video. 

12. Play with Animals

Petting your own dog or another person’s dog has been shown to significantly decrease stress hormone levels and increase oxytocin, endorphins, and other healing hormones (71, 73). 

Researchers have also compared 20 minutes of quiet rest to 20 minutes of interaction with a dog, and they found that hanging out with dog contributed to a much more significant decrease in cortisol. This is often why therapy dogs show up on college campuses during exams (71). 

So you should try to hang out with animals as much as possible, and consider getting a house pet if you don’t have one. I have a cat named Puddy. 

Spending time in nature has also been shown to reduce cortisol levels. So you can kill two birds with one stone by taking your pet for a walk in the park (77). 

Hmm perhaps “kill two birds with one stone” wasn’t the best idiom to use in this section, but you get my point. 

13. Listen to Music and Dance

Music is actually healing and can have a calming effect on the brain. 

Numerous studies show that music can relax you, especially before a stressful event, by significantly lowering stress hormones. It can also reduce the spike in cortisol during the stressful situation (50-54). 

Music can be even more relaxing when combined with non-strenuous dancing.

Regular dancing has also been shown to greatly decrease cortisol levels (55). 

14. Practice Relaxation Techniques and Therapies

Not too surprisingly, simply taking time each day to relax can lower cortisol.  

My favourite relaxation technique is meditation. 

Countless studies show that meditating daily for just 15 minutes can significantly lower stress hormone levels and blunt cortisol spikes (38-43). 

I use the Muse headband to meditate. Similar to neurofeedback, it gives you real-time feedback on your brainwaves. I previously wrote about it here, and you can get it through the Muse website. 

Yoga has also been shown to lower cortisol. 

In one study, people with depression practiced yoga regularly for 3 months. By the end of the study, their cortisol levels dropped significantly and they experienced relief from their depression (44). 

Massage is another excellent option, as it’s been shown in many studies to significant decrease in cortisol and anxiety (45, 46). 

I get a massage every couple of months. 

Emotional Freedom Technique, or “tapping”, is another tool I use to manage stress. 

Tapping is based on ancient Chinese acupressure and modern psychology. You can learn how to practice it here. 

I know it seems hokey, but it works. 

It’s been shown to significantly decrease cortisol levels (47). 

The book The Tapping Solution: A Revolutionary System for Stress-Free Living goes in more depth about the practice. 

Lastly, deep breathing exercises can help you manage your stress hormone levels. 

Diaphragmatic breathing – consciously breathing from your diaphragm – has been shown to encourage the body’s natural relaxation response and reduce cortisol (48, 49). 

I use the EmWave2 device every day to reduce stress and make sure I’m breathing optimally. I wrote about it before here.

15. Exercise (But Not Too Much)

Exercise is definitely good for you. It can balance hormones and reduce stress by releasing endorphins. However, overtraining can actually backfire and increase stress hormone levels (112). 

That’s why I don’t really recommend chronic endurance exercise and prefer weightlifting and high-intensity sprinting over cardio. 

Research shows that prolonged aerobic exercise can increase cortisol levels, and marathon runners have higher levels of cortisol (111, 113). 

16. Get More Deep Sleep

This might be the most important step. 

Getting enough high-quality sleep is critical for your brain and mental health. 

My sleep used to be terrible and it was one of main factors that contributed to my poor mental health. And then my poor mental health would make my sleep worse. So it was a vicious cycle. 

Let me explain.

Normally, cortisol increases in the morning and then drops very low at night prior to bed. But if you have chronic stress and high cortisol, you can end up feeling wired and anxious at night, making it more difficult to sleep. 

Unfortunately, staying up late when your body expects to be asleep further increases your stress hormone levels even more. And lack of sleep and interrupted sleep have been shown to significantly increase cortisol throughout the next day and contribute to cognitive problems down the road (56-61, 63). 

So it’s clearly a vicious cycle where high cortisol causes sleep problems, and poor sleep increases stress.  

That’s why it’s so important go to bed at the same time every night and aim for at least 7 hours of sleep every night. Without doing that, you can end up with dysregulated daytime cortisol production.

And it’s not just the amount of sleep you get that’s important. It’s also the quality of sleep. In fact, the quality of your sleep is more important than the length of your sleep.

So I would try doing everything you can to maximize the quality of your sleep. 

I share my very best sleep tips with my clients through our Brain Recovery Accelerator Program. We have a free online workshop that talks about the program. You can register for the workshop here.

You could also take this sleep supplement, which contains magnesium and a number of other natural compounds that I’ve used over the years to improve sleep.

And if you don’t get enough sleep one night, try to take a nap sometime the next day. Daytime napping after a night of sleep loss has been shown to cause beneficial changes in cortisol levels (62).

17. Chew Aspartame-Free Gum

Next time you’re stressed, try chewing a piece of gum. 

It’s an easy way to lower your stress hormone levels. 

According to one study, chewing gum while under moderate stress reduces mental stress and decreases cortisol by 12 per cent. Previous studies have also shown that chewing can increase alertness, neural activity and blood flow to the brain (82). 

I prefer if the gum is aspartame-free.

18. Stand Tall

Changing your body language can have a powerful effect on your biology. 

Standing tall for just two minutes can lower your cortisol by 25 per cent, according to a famous study led by Harvard social psychologist Amy Cuddy (83). 

Cuddy’s research found that if you switch from low-power body language (arms crossed, hunched over, closed up, slumped shoulders, nervous) to high-power body language (opened up, tall, relaxed, confident), your hormones will change to match your new posture (84). 

So try your best to maintain high-power body language as much as possible as it can reduce stress hormones and increase confidence. You could even try holding a dominant pose for 2 minutes every day. You’ll likely find yourself feeling calmer and more mentally powerful.

And if you haven’t already, check out Amy Cuddy’s TED talk “Your Body Language Shapes Who You Are”.

I also recommend her book Presence: Bringing Your Boldest Self to Your Biggest Challenges.

19. Socialize

Social connectivity and positive social interactions also significantly reduce stress hormone levels.

Research shows that the more social support a person has, the lower their cortisol levels will be (67). 

This is likely because you release the hormone oxytocin during social contact and social bonding, and oxytocin has been proven to decrease anxiety and block increases in cortisol (68). 

One study states that “the combination of oxytocin and social support exhibited the lowest cortisol concentrations as well as increased calmness during stress” (69). 

Animal studies have also discovered that social isolation leads to higher cortisol and mental health problems (70). 

Make sure to check out my full article about oxytocin to learn more about this powerful neurotransmitter.

20. Other Cutting-Edge Therapies

Here are some other therapies that have been shown to reduce stress and cortisol:

• Bright Light Therapy (85, 86).

• Transcranial direct current stimulation (78)

• Transcranial magnetic stimulation (79, 80)

• Acupuncture (92)

Conclusion

It’s important to take control of your stress before it takes control over you.

Thankfully, there are so many ways to manage your stress and lower cortisol levels without having to resort to a prescription. 

Here’s a summary of everything we’ve gone over to reduce stress hormone levels:

• Eat wild salmon, grass-fed beef and krill oil, and avoid refined vegetable oils

• Drink black, green and chamomile tea, or supplement with theanine

• Eat dark chocolate :-)

• Get enough antioxidants, including vitamin C, vitamin E, glutathione and CoQ10

• Eat turmeric and/or supplement with curcumin

• Add extra virgin olive oil to meals

• Relax with meditation, the Muse headband, yoga, massage, tapping, deep breathing, and the EmWave2

• Listen to music and dance

• Sleep deeper

• Watch comedy and laugh

• Socialize

• Play with animals

• Chew aspartame-free gum

• Stand tall with powerful body language

• Limit alcohol and caffeine

• Eat prebiotic foods, including resistant starch

• Eat enough food and protein

• Drink enough filtered-water

• Exercise, but not too much

• Supplement with phosphatidylserine, ashwagandha, rhodiola and/or minerals

I remember when I first discovered all of these tools and strategies, it gave me so much hope that I could get better and overcome my depression and anxiety.

And I thankfully I did.

And you can too. 

Let me know what you think in the comments. Have you ever had high cortisol? Do you have any other tips that have helped you reduce cortisol?

Enjoy This Article? You Might Also Like My FREE Food Guide for Optimal Brain and Mental Health!

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Live Optimally,

Jordan Fallis

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References:

(1) http://www.ncbi.nlm.nih.gov/pubmed/12909818

(2) http://www.ncbi.nlm.nih.gov/pubmed/17013636

(3) http://www.ncbi.nlm.nih.gov/pubmed/23208960

(4) http://ajcn.nutrition.org/content/71/1/179S.long

(5) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618203/

(6) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC533861/

(7) http://www.ncbi.nlm.nih.gov/pubmed/12777162

(8) http://www.ncbi.nlm.nih.gov/pubmed/14579682

(9) http://www.ncbi.nlm.nih.gov/pubmed/12442909

(10) http://www.ncbi.nlm.nih.gov/pubmed/20932294

(11) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081099/

(12) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560823/

(13) http://www.ncbi.nlm.nih.gov/pubmed/26797633

(14) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995283/

(15) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995283/

(16) http://pubs.acs.org/doi/abs/10.1021/pr900607v?prevSearch=kochhar&searchHistoryKey

(17) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350893/

(18) https://www.ncbi.nlm.nih.gov/pubmed/24404164/

(19) http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020795

(20) http://link.springer.com/article/10.2165/11594400-000000000-00000

(21) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761741/

(22) http://www.sciencedirect.com/science/article/pii/S0300483X03001513

(23) http://www.sciencedirect.com/science/article/pii/S0955286306002348

(24)http://www.researchgate.net/publication/227685141_Anthocyanin_Pigments_Comparison_of_Extract_Stability

(25) http://www.ncbi.nlm.nih.gov/pubmed/16042916

(26) http://www.ncbi.nlm.nih.gov/pubmed/21069377

(27) http://www.ncbi.nlm.nih.gov/pubmed/18427418

(28) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC201008/

(29) http://www.ncbi.nlm.nih.gov/pubmed/12208645

(30) http://www.ncbi.nlm.nih.gov/pubmed/21036190

(31) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560823/

(32) http://www.ncbi.nlm.nih.gov/pubmed/21839761

(33) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853174/

(34) http://www.ncbi.nlm.nih.gov/pubmed/20920780

(35) http://www.ncbi.nlm.nih.gov/pubmed/19540859

(36) http://www.cjpt.ac.cn/EN/abstract/abstract1590.shtml

(37) http://www.ergo-log.com/oleuropein-boosts-testosterone-lowers-cortisol-stimulates-anabolism.html

(38) http://www.ergo-log.com/meditationhormones.html

(39) http://www.ncbi.nlm.nih.gov/pubmed/23724462

(40) http://www.ncbi.nlm.nih.gov/pubmed/1801007

(41) http://www.ncbi.nlm.nih.gov/pubmed/22377965

(42) http://archinte.jamanetwork.com/article.aspx?articleid=1809754

(43) http://www.sciencedirect.com/science/article/pii/030105119505118T

(44) http://www.ncbi.nlm.nih.gov/pubmed/24049209

(45) http://www.ncbi.nlm.nih.gov/pubmed/8707483

(46) http://www.ncbi.nlm.nih.gov/pubmed/16162447

(47) http://www.ncbi.nlm.nih.gov/pubmed/22986277

(48) http://www.ncbi.nlm.nih.gov/pubmed/20617660

(49) http://www.ncbi.nl m.nih.gov/pmc/articles/PMC3573542/

(50) https://www.ncbi.nlm.nih.gov/pubmed/15086180

(51) http://www.medicalnewstoday.com/articles/258383.php

(52) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110826/

(53) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734071/

(54) http://medind.nic.in/jau/t10/i2/jaut10i2p70.pdf

(55) http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.403.4566&rep=rep1&type=pdf

(56) http://press.endocrine.org/doi/abs/10.1210/jcem-33-1-14

(57) http://www.ncbi.nlm.nih.gov/pubmed/9415946

(58) http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0041218

(59) https://www.hindawi.com/journals/ije/2010/759234/

(60) http://www.ncbi.nlm.nih.gov/pubmed/6822642

(61) http://www.ncbi.nlm.nih.gov/pubmed/10704520

(62) http://www.ncbi.nlm.nih.gov/pubmed/16940468

(63) http://www.ncbi.nlm.nih.gov/pubmed/15558991

(64) http://www.ncbi.nlm.nih.gov/pubmed/24682001

(65) http://www.ncbi.nlm.nih.gov/pubmed/2556917

(66) http://www.fasebj.org/cgi/content/meeting_abstract/22/1_MeetingAbstracts/946.11

(67) http://www.ncbi.nlm.nih.gov/pubmed/15473629

(68) http://www.ncbi.nlm.nih.gov/pubmed/15219651

(69) http://www.ncbi.nlm.nih.gov/pubmed/14675803

(70) https://www.psychologytoday.com/blog/the-athletes-way/201301/cortisol-why-the-stress-hormone-is-public-enemy-no-1

(71) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408111/

(72) http://www.ncbi.nlm.nih.gov/pubmed/18221981

(73) http://www.sciencealert.com/having-a-dog-can-reduce-anxiety-and-stress-in-children-study-finds

(74) http://www.ncbi.nlm.nih.gov/pubmed/18458357

(75) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2249754/

(76) https://www.ncbi.nlm.nih.gov/pubmed/16631247

(77) http://www.ncbi.nlm.nih.gov/pubmed/19568835

(78) http://www.ncbi.nlm.nih.gov/pubmed/22626867

(79) http://www.sciencedirect.com/science/article/pii/S1000194810600044

(80) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181968/

(81) http://www.ncbi.nlm.nih.gov/pubmed/17006802

(82) http://www.hindawi.com/journals/bmri/aa/876409

(83) http://www.people.hbs.edu/acuddy/in press, carney, cuddy, & yap, psych science.pdf

(84) http://www.ncbi.nlm.nih.gov/pubmed/20855902

(85) http://www.ncbi.nlm.nih.gov/pubmed/21199966

(86) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686562/

(87) http://link.springer.com/article/10.1007/s00213-014-3810-0%20/fulltext.html

(88) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2257922/

(89) https://www.ncbi.nlm.nih.gov/pubmed/2195579

(90) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266962/

(91) https://www.sciencedaily.com/releases/2010/09/100907163313.htm

(92) http://www.ncbi.nlm.nih.gov/pubmed/19765402

(93) https://www.ncbi.nlm.nih.gov/pubmed/12909818

(94) https://www.ncbi.nlm.nih.gov/pubmed/23390041

(95) https://www.ncbi.nlm.nih.gov/pubmed/23726389

(96) https://www.ncbi.nlm.nih.gov/pubmed/19554276

(97) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560823/

(98) https://www.ncbi.nlm.nih.gov/pubmed/14737017

(99) http://www.sciencedirect.com/science/article/pii/S0304394003003008

(100) https://www.ncbi.nlm.nih.gov/pubmed/23789222

(101) https://www.ncbi.nlm.nih.gov/pubmed/23788517

(102) https://www.ncbi.nlm.nih.gov/pubmed/25141817

(103) https://www.ncbi.nlm.nih.gov/pubmed/19323371

(104) https://www.ncbi.nlm.nih.gov/pubmed/14737017

(105) https://www.ncbi.nlm.nih.gov/pubmed/11526469

(106) https://www.ncbi.nlm.nih.gov/pubmed/19865069/

(107) https://www.ncbi.nlm.nih.gov/pubmed/9142558

(108) https://www.ncbi.nlm.nih.gov/pubmed/3080766

(109) https://www.ncbi.nlm.nih.gov/pubmed/19211813

(110) http://www.ncbi.nlm.nih.gov/pubmed/21719534

(111) https://www.ncbi.nlm.nih.gov/pubmed/10190775

(112) http://www.health.harvard.edu/staying-healthy/exercising-to-relax

(113) https://www.ncbi.nlm.nih.gov/pubmed/3817754

(114) http://www.ncbi.nlm.nih.gov/pubmed/22017963

(115) http://www.ncbi.nlm.nih.gov/pubmed/21103034

(116) http://www.ncbi.nlm.nih.gov/pubmed/20523044

(117) https://www.ncbi.nlm.nih.gov/pubmed/1325348

(118) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503954/

(119) https://www.ncbi.nlm.nih.gov/pubmed/15512856

(120) https://www.ncbi.nlm.nih.gov/pubmed/18662395

(121) http://www.ncbi.nlm.nih.gov/pubmed/23439798

(122) http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.324.8921

(123) http://www.ncbi.nlm.nih.gov/pubmed/19789214

(124) http://www.ncbi.nlm.nih.gov/pubmed/19170145

(125) https://www.ncbi.nlm.nih.gov/m/pubmed/25101546

(126) http://www.ncbi.nlm.nih.gov/pubmed/21036578

(127) http://link.springer.com/article/10.1007/BF02789143

(128) http://www.degruyter.com/view/j/cclm.1984.22.issue-11/cclm.1984.22.11.717/cclm.1984.22.11.717.xml

(129) http://www.ncbi.nlm.nih.gov/pubmed/6527092

(130) http://www.ncbi.nlm.nih.gov/pubmed/21835188

(131) http://www.ncbi.nlm.nih.gov/pubmed/6527092

(132) http://www.ncbi.nlm.nih.gov/pubmed/19931332

(133) http://www.ncbi.nlm.nih.gov/pubmed/1702662

(134) http://www.sciencedirect.com/science/article/pii/S0925443911000329

(135) http://news.berkeley.edu/2014/02/11/chronic-stress-predisposes-brain-to-mental-illness/

(136) http://dujs.dartmouth.edu/fall-2010/the-physiology-of-stress-cortisol-and-the-hypothalamic-pituitary-adrenal-axis#.VN9JHFXF8a4

(137) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312696/

(138) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186928/

(139) http://news.berkeley.edu/2014/02/11/chronic-stress-predisposes-brain-to-mental-illness/

(140) http://www.nature.com/mp/journal/vaop/ncurrent/full/mp2013190a.html%20

(141) https://www.ncbi.nlm.nih.gov/pubmed/23946275

(142) http://www.ncbi.nlm.nih.gov/pubmed/12537036

(143) https://www.ncbi.nlm.nih.gov/pubmed/22564216

(144) http://dujs.dartmouth.edu/fall-2010/the-physiology-of-stress-cortisol-and-the-hypothalamic-pituitary-adrenal-axis#.VN9JHFXF8a4

(145) https://www.ncbi.nlm.nih.gov/pubmed/10890824

(146) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576517/

(147) https://www.ncbi.nlm.nih.gov/pubmed/17028025

(148) https://www.ncbi.nlm.nih.gov/pubmed/17028025

(149) https://en.wikipedia.org/wiki/Hypothalamic%E2%80%93pituitary%E2%80%93adrenal_axis

(150) https://www.eurekalert.org/pub_releases/2012-09/dc-wmo092412.php

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